Reviewed, UniProtKB/Swiss-Prot A8GFQ3 (ASTD_SERP5)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	Spro_2842

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_1000065763
Regions
	Nucleotide binding	223 – 228	6	NAD By similarity
Sites
	Active site	246	1	By similarity
	Active site	280	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8GFQ3-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 8DB57EC365C40843	FASTA	490	52,392
	10 20 30 40 50 60 MSHPALFING AWQQGRGAEF SKTDPVDNQP LWQANAADGS DVAAACEAAR AAFPAWARTP 70 80 90 100 110 120 FEQREQLVKR FAALLEEHKS HLAATISRET SKPRWETLTE VQAMIGKVAI SLQAYQVRTG 130 140 150 160 170 180 VSQTAMADGA SVLRHRPHGV LAVFGPYNFP GHLPNGHIVP ALLAGNTVVF KPSELTPQTA 190 200 210 220 230 240 EETLKLWQQA GLPDGVINMV QGGRETGEAL AASTDIDGLL FTGSAGTGYH LHRQLAGQPE 250 260 270 280 290 300 KILALEMGGN NALIVDQIED CDAAVNLAIQ SAFISAGQRC TCSRRILVKR GSEGDAFIER 310 320 330 340 350 360 LVQVASALRI GRWDAEPQPF MGGVISSAAA EKMLAAQHHL LSLGGKALLT MQRLESGSAL 370 380 390 400 410 420 LSPGIIDVTG VRDVPDEEYF GPLTTIIRYN DFDEAVRIAN QTRYGLSVGL VSPQRERFDH 430 440 450 460 470 480 LLLEARAGIV NWNKPLTGAS SAAPFGGVGA SGNHRPSAYY AADYCAWPMA SLESESLTLP 490 ASLSPGLSFN

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000826 Genomic DNA. Translation: ABV41943.1.
RefSeq	YP_001479071.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5603120.
GenomeReviews	Gene locus Spro_2842 in contig CP000826_GR.
KEGG	spe:Spro_2842.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_SERP5

Accession

Primary (citable) accession number: A8GFQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	November 25, 2008
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)