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A8GF39

- GCH4_SERP5

UniProt

A8GF39 - GCH4_SERP5

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei157 – 1571May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSPRO399741:GI55-2687-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Spro_2628
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309GTP cyclohydrolase FolE2PRO_0000318553Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_2628.

Structurei

3D structure databases

ProteinModelPortaliA8GF39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GF39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKVALPPTQ PLPDAQAWQG AMSDVGLDWV GMQGIALPLE LAGKPLMAKV
60 70 80 90 100
NAGINLRASR HGARGIHMSR LYLTLDELTQ GELTPQRIAD SLRAFLASQP
110 120 130 140 150
EHSDSASLSI SGELMLSRPA LLSAHRGWKA YPLKIDASLT TGLTLSLTVG
160 170 180 190 200
VPYSSTCPSS AALSRQLAQQ QFQFDFEQAP DKVSQQQVID WLGEQGMPGT
210 220 230 240 250
PHSQRSWAWV TVTLNEGEAE LPVVNLIDRI EHALGTPLQT LVKRQDEQAF
260 270 280 290 300
ALANGQNLMF CEDAARRLYR MLRSQCHHRA FSLRVEHQES LHAHNAVAEL

SWQEAGNAA
Length:309
Mass (Da):33,879
Last modified:November 13, 2007 - v1
Checksum:i24E753FA838097F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV41729.1.
RefSeqiWP_012145356.1. NC_009832.1.
YP_001478857.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV41729; ABV41729; Spro_2628.
GeneIDi5605259.
KEGGispe:Spro_2628.
PATRICi32418009. VBISerPro44537_2679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV41729.1 .
RefSeqi WP_012145356.1. NC_009832.1.
YP_001478857.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GF39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399741.Spro_2628.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV41729 ; ABV41729 ; Spro_2628 .
GeneIDi 5605259.
KEGGi spe:Spro_2628.
PATRICi 32418009. VBISerPro44537_2679.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SPRO399741:GI55-2687-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiGCH4_SERP5
AccessioniPrimary (citable) accession number: A8GF39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3