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A8GF39

- GCH4_SERP5

UniProt

A8GF39 - GCH4_SERP5

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Spro_2628
Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei157 – 1571May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSPRO399741:GI55-2687-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Spro_2628
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309GTP cyclohydrolase FolE2UniRule annotationPRO_0000318553Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_2628.

Structurei

3D structure databases

ProteinModelPortaliA8GF39.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GF39-1 [UniParc]FASTAAdd to Basket

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MNKVALPPTQ PLPDAQAWQG AMSDVGLDWV GMQGIALPLE LAGKPLMAKV    50
NAGINLRASR HGARGIHMSR LYLTLDELTQ GELTPQRIAD SLRAFLASQP 100
EHSDSASLSI SGELMLSRPA LLSAHRGWKA YPLKIDASLT TGLTLSLTVG 150
VPYSSTCPSS AALSRQLAQQ QFQFDFEQAP DKVSQQQVID WLGEQGMPGT 200
PHSQRSWAWV TVTLNEGEAE LPVVNLIDRI EHALGTPLQT LVKRQDEQAF 250
ALANGQNLMF CEDAARRLYR MLRSQCHHRA FSLRVEHQES LHAHNAVAEL 300
SWQEAGNAA 309
Length:309
Mass (Da):33,879
Last modified:November 13, 2007 - v1
Checksum:i24E753FA838097F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV41729.1.
RefSeqiWP_012145356.1. NC_009832.1.
YP_001478857.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV41729; ABV41729; Spro_2628.
GeneIDi5605259.
KEGGispe:Spro_2628.
PATRICi32418009. VBISerPro44537_2679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV41729.1 .
RefSeqi WP_012145356.1. NC_009832.1.
YP_001478857.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GF39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399741.Spro_2628.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV41729 ; ABV41729 ; Spro_2628 .
GeneIDi 5605259.
KEGGi spe:Spro_2628.
PATRICi 32418009. VBISerPro44537_2679.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SPRO399741:GI55-2687-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiGCH4_SERP5
AccessioniPrimary (citable) accession number: A8GF39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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