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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Spro_2628
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185531 – 309GTP cyclohydrolase FolE2Add BLAST309

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_2628

Structurei

3D structure databases

ProteinModelPortaliA8GF39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UHU Bacteria
COG1469 LUCA
HOGENOMiHOG000247517
KOiK09007
OMAiPYSSTCP
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

A8GF39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKVALPPTQ PLPDAQAWQG AMSDVGLDWV GMQGIALPLE LAGKPLMAKV
60 70 80 90 100
NAGINLRASR HGARGIHMSR LYLTLDELTQ GELTPQRIAD SLRAFLASQP
110 120 130 140 150
EHSDSASLSI SGELMLSRPA LLSAHRGWKA YPLKIDASLT TGLTLSLTVG
160 170 180 190 200
VPYSSTCPSS AALSRQLAQQ QFQFDFEQAP DKVSQQQVID WLGEQGMPGT
210 220 230 240 250
PHSQRSWAWV TVTLNEGEAE LPVVNLIDRI EHALGTPLQT LVKRQDEQAF
260 270 280 290 300
ALANGQNLMF CEDAARRLYR MLRSQCHHRA FSLRVEHQES LHAHNAVAEL

SWQEAGNAA
Length:309
Mass (Da):33,879
Last modified:November 13, 2007 - v1
Checksum:i24E753FA838097F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV41729.1
RefSeqiWP_012145356.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV41729; ABV41729; Spro_2628
KEGGispe:Spro_2628

Similar proteinsi

Entry informationi

Entry nameiGCH4_SERP5
AccessioniPrimary (citable) accession number: A8GF39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health