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A8GF39

- GCH4_SERP5

UniProt

A8GF39 - GCH4_SERP5

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei157 – 1571May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSPRO399741:GI55-2687-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Spro_2628
    OrganismiSerratia proteamaculans (strain 568)
    Taxonomic identifieri399741 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
    ProteomesiUP000007074: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309GTP cyclohydrolase FolE2PRO_0000318553Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399741.Spro_2628.

    Structurei

    3D structure databases

    ProteinModelPortaliA8GF39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiAGRTTIQ.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8GF39-1 [UniParc]FASTAAdd to Basket

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    MNKVALPPTQ PLPDAQAWQG AMSDVGLDWV GMQGIALPLE LAGKPLMAKV    50
    NAGINLRASR HGARGIHMSR LYLTLDELTQ GELTPQRIAD SLRAFLASQP 100
    EHSDSASLSI SGELMLSRPA LLSAHRGWKA YPLKIDASLT TGLTLSLTVG 150
    VPYSSTCPSS AALSRQLAQQ QFQFDFEQAP DKVSQQQVID WLGEQGMPGT 200
    PHSQRSWAWV TVTLNEGEAE LPVVNLIDRI EHALGTPLQT LVKRQDEQAF 250
    ALANGQNLMF CEDAARRLYR MLRSQCHHRA FSLRVEHQES LHAHNAVAEL 300
    SWQEAGNAA 309
    Length:309
    Mass (Da):33,879
    Last modified:November 13, 2007 - v1
    Checksum:i24E753FA838097F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000826 Genomic DNA. Translation: ABV41729.1.
    RefSeqiWP_012145356.1. NC_009832.1.
    YP_001478857.1. NC_009832.1.

    Genome annotation databases

    EnsemblBacteriaiABV41729; ABV41729; Spro_2628.
    GeneIDi5605259.
    KEGGispe:Spro_2628.
    PATRICi32418009. VBISerPro44537_2679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000826 Genomic DNA. Translation: ABV41729.1 .
    RefSeqi WP_012145356.1. NC_009832.1.
    YP_001478857.1. NC_009832.1.

    3D structure databases

    ProteinModelPortali A8GF39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399741.Spro_2628.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV41729 ; ABV41729 ; Spro_2628 .
    GeneIDi 5605259.
    KEGGi spe:Spro_2628.
    PATRICi 32418009. VBISerPro44537_2679.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi AGRTTIQ.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci SPRO399741:GI55-2687-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 568.

    Entry informationi

    Entry nameiGCH4_SERP5
    AccessioniPrimary (citable) accession number: A8GF39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3