Reviewed, UniProtKB/Swiss-Prot A8GE04 (ARAA_SERP5)

Names and origin

Protein names

Recommended name:
    L-arabinose isomerase
    EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	Spro_2243

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity.
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity.
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Subunit structure	Homohexamer By similarity.
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	L-arabinose isomerase HAMAP MF_00519		PRO_1000060915
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	333	1	Manganese By similarity
	Metal binding	350	1	Manganese By similarity
	Metal binding	450	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8GE04-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: FA6D0137885BFE88	FASTA	501	55,820
	10 20 30 40 50 60 MNAFKQREVW FAIGSQHLYG PQTLQQVKAH AEQVVDSLNR EAGLPVKLVL KPLVTTPDEI 70 80 90 100 110 120 TALCRDANYQ PQCIGILAWL HTFSPAKMWI AGLSVLHKPL LQFHTQFNAQ VPWDSMDMDF 130 140 150 160 170 180 MNLNQTAHGG REFGFIGARM RQQHSVIAGH WQDPEAHRRI GQWMRVASAK QAGQQLKVAR 190 200 210 220 230 240 FGDNMREVAV TDGDKVGAQI QFGYSVNAYG IGDLVSVINE VSRGDVDTLI EEYEASYVLS 250 260 270 280 290 300 DAAKINGAKR ENLTDAARIE LGMKRFLEQG NFQAFTTNFE DLHGMKQLPG LAVQRLMQQG 310 320 330 340 350 360 YGFGGEGDWK TAALLRILKV MADGLHGGTS FMEDYTYHFQ PGNDLVVGSH MLEVCPSIAR 370 380 390 400 410 420 EPKPLLDIQP LGIGGKADPA RLIFSTPAGP AVNASLIDMG DRFRLLVNQV DTVEQPHPLP 430 440 450 460 470 480 KLPVARAIWR AQPTLATAAE AWILAGGAHH TVFSQALDAD MLRLYAEMHN IEFLLIDQDT 490 500 TLPAFKNELR WNEAYYQLNR R

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000826 Genomic DNA. Translation: ABV41344.1.
RefSeq	YP_001478472.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8GE04.
Genome annotation databases
GeneID	5605121.
GenomeReviews	Gene locus Spro_2243 in contig CP000826_GR.
KEGG	spe:Spro_2243.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EVCPTIA.
Family and domain databases
HAMAP	MF_00519. [Tree]
InterPro	IPR003762. Lara_isomerase. [Graphical view]
Pfam	PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ARAA_SERP5

Accession

Primary (citable) accession number: A8GE04

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)