Skip Header

Contribute Send feedback
Read comments (?) or add your own

A8GDA7 (KDSA_SERP5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene names
Name:kdsA
Ordered Locus Names:Spro_1994
OrganismSerratia proteamaculans (strain 568) [Complete proteome] [HAMAP]
Taxonomic identifier399741 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056

Pathway

Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056

Subcellular location

Cytoplasm By similarity HAMAP MF_00056.

Sequence similarities

Belongs to the KdsA family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-deoxy-8-phosphooctulonate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2842842-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056
PRO_1000057398

Sequences

Sequence LengthMass (Da)Tools
A8GDA7 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 833B1B69F42AFC96

FASTA28430,717
        10         20         30         40         50         60 
MKQKVVSIGD INVANDLPFV LFGGMNVLES RDLAMRICEH YVTVTQKLGI PYVFKASFDK 

        70         80         90        100        110        120 
ANRSSIHSYR GPGLEEGMKI FEEIKKTFGV KTITDVHEAS QAQPVSEVVD VIQLPAFLAR 

       130        140        150        160        170        180 
QTDLVEAMAK TGAVINVKKP QFVSPGQMGN IVDKFKEGGN DQVILCDRGS NFGYDNLVVD 

       190        200        210        220        230        240 
MLGINVMKNA TGGHPVIFDV THALQTRDPF GAASGGRRAQ VAELARAGMA VGLAGLFIEA 

       250        260        270        280 
HPEPNSAKCD GPSALPLDKL EPFLVQMKAI DDLVKSFPEL DTSN

« Hide

References

[1]"Complete sequence of chromosome of Serratia proteamaculans 568."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 568.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000826 Genomic DNA. Translation: ABV41097.1.
RefSeqYP_001478225.1. NC_009832.1.

3D structure databases

ProteinModelPortalA8GDA7.
SMRA8GDA7. Positions 1-283.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8GDA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5603500.
GenomeReviewsGene locus Spro_1994 in contig CP000826_GR.
KEGGspe:Spro_1994.
PATRIC32416705. VBISerPro44537_2030.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2877.
HOGENOMHBG575990.
OMAQLILCDR.
ProtClustDBPRK05198.

Enzyme and pathway databases

BioCycSPRO399741:SPRO_1994-MONOMER.

Family and domain databases

HAMAPMF_00056. KDO8P_synth.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01627.
PANTHERPTHR21057:SF2. KDO8P_synthase. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01362. KDO8P_synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSA_SERP5
AccessionPrimary (citable) accession number: A8GDA7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents