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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Spro_1732
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000611691 – 401Nicotinate phosphoribosyltransferaseAdd BLAST401

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_1732

Structurei

3D structure databases

ProteinModelPortaliA8GCJ6
SMRiA8GCJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

A8GCJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQYASPILT SLLDTDAYKL HMQQAVFHRY PAISVAAEFR CRGDELLGEY
60 70 80 90 100
ADEIGAQIAL MSQLALTDAE FDYLSGLPFF REDYLNWLRD FRYDPQQVQI
110 120 130 140 150
ENHAGKLHIR IAGPWREVIM WEVPLLAVIS EVVHRHRSPD VTPEMAVAHL
160 170 180 190 200
RNKLAQFKAM SSDVDISRFK LMDFGTRRRF SQAVQQAIVG TLKNEFPYLV
210 220 230 240 250
GTSNYDLAHQ LDLAPVGTQA HEWFQAHQQI SPVLANSQRA ALQAWLDEYP
260 270 280 290 300
DQLGIALTDC ITMDAFLRDF GPQFAQRYQG LRHDSGDPFE WGEKAIAHFQ
310 320 330 340 350
KLGIDPMSKT LVFSDNLDLD KALALYRHFY QRVNLVFGIG TRLTCDIPGV
360 370 380 390 400
KPLNIVIKLV ECKGKPVAKL SDSPGKTICQ DQAFVKALRK AFDLPLVKKA

S
Length:401
Mass (Da):45,452
Last modified:November 13, 2007 - v1
Checksum:i84A2D01CD36318F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV40836.1
RefSeqiWP_012006159.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV40836; ABV40836; Spro_1732
KEGGispe:Spro_1732

Similar proteinsi

Entry informationi

Entry nameiPNCB_SERP5
AccessioniPrimary (citable) accession number: A8GCJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health