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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSPRO399741:GI55-1782-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Spro_1732
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Nicotinate phosphoribosyltransferasePRO_1000061169Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_1732.

Structurei

3D structure databases

ProteinModelPortaliA8GCJ6.
SMRiA8GCJ6. Positions 3-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GCJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQYASPILT SLLDTDAYKL HMQQAVFHRY PAISVAAEFR CRGDELLGEY
60 70 80 90 100
ADEIGAQIAL MSQLALTDAE FDYLSGLPFF REDYLNWLRD FRYDPQQVQI
110 120 130 140 150
ENHAGKLHIR IAGPWREVIM WEVPLLAVIS EVVHRHRSPD VTPEMAVAHL
160 170 180 190 200
RNKLAQFKAM SSDVDISRFK LMDFGTRRRF SQAVQQAIVG TLKNEFPYLV
210 220 230 240 250
GTSNYDLAHQ LDLAPVGTQA HEWFQAHQQI SPVLANSQRA ALQAWLDEYP
260 270 280 290 300
DQLGIALTDC ITMDAFLRDF GPQFAQRYQG LRHDSGDPFE WGEKAIAHFQ
310 320 330 340 350
KLGIDPMSKT LVFSDNLDLD KALALYRHFY QRVNLVFGIG TRLTCDIPGV
360 370 380 390 400
KPLNIVIKLV ECKGKPVAKL SDSPGKTICQ DQAFVKALRK AFDLPLVKKA

S
Length:401
Mass (Da):45,452
Last modified:November 13, 2007 - v1
Checksum:i84A2D01CD36318F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV40836.1.
RefSeqiYP_001477964.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV40836; ABV40836; Spro_1732.
GeneIDi5604586.
KEGGispe:Spro_1732.
PATRICi32416157. VBISerPro44537_1763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV40836.1.
RefSeqiYP_001477964.1. NC_009832.1.

3D structure databases

ProteinModelPortaliA8GCJ6.
SMRiA8GCJ6. Positions 3-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399741.Spro_1732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV40836; ABV40836; Spro_1732.
GeneIDi5604586.
KEGGispe:Spro_1732.
PATRICi32416157. VBISerPro44537_1763.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
BioCyciSPRO399741:GI55-1782-MONOMER.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiPNCB_SERP5
AccessioniPrimary (citable) accession number: A8GCJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: February 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.