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A8GCJ6

- PNCB_SERP5

UniProt

A8GCJ6 - PNCB_SERP5

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, Spro_1732
Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSPRO399741:GI55-1782-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:Spro_1732
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_1000061169Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_1732.

Structurei

3D structure databases

ProteinModelPortaliA8GCJ6.
SMRiA8GCJ6. Positions 3-377.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A8GCJ6-1 [UniParc]FASTAAdd to Basket

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MTQYASPILT SLLDTDAYKL HMQQAVFHRY PAISVAAEFR CRGDELLGEY    50
ADEIGAQIAL MSQLALTDAE FDYLSGLPFF REDYLNWLRD FRYDPQQVQI 100
ENHAGKLHIR IAGPWREVIM WEVPLLAVIS EVVHRHRSPD VTPEMAVAHL 150
RNKLAQFKAM SSDVDISRFK LMDFGTRRRF SQAVQQAIVG TLKNEFPYLV 200
GTSNYDLAHQ LDLAPVGTQA HEWFQAHQQI SPVLANSQRA ALQAWLDEYP 250
DQLGIALTDC ITMDAFLRDF GPQFAQRYQG LRHDSGDPFE WGEKAIAHFQ 300
KLGIDPMSKT LVFSDNLDLD KALALYRHFY QRVNLVFGIG TRLTCDIPGV 350
KPLNIVIKLV ECKGKPVAKL SDSPGKTICQ DQAFVKALRK AFDLPLVKKA 400
S 401
Length:401
Mass (Da):45,452
Last modified:November 13, 2007 - v1
Checksum:i84A2D01CD36318F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV40836.1.
RefSeqiYP_001477964.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV40836; ABV40836; Spro_1732.
GeneIDi5604586.
KEGGispe:Spro_1732.
PATRICi32416157. VBISerPro44537_1763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV40836.1 .
RefSeqi YP_001477964.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GCJ6.
SMRi A8GCJ6. Positions 3-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399741.Spro_1732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV40836 ; ABV40836 ; Spro_1732 .
GeneIDi 5604586.
KEGGi spe:Spro_1732.
PATRICi 32416157. VBISerPro44537_1763.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci SPRO399741:GI55-1782-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiPNCB_SERP5
AccessioniPrimary (citable) accession number: A8GCJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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