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A8GC76 (A8GC76_SERP5) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Imidazole glycerol phosphate synthase subunit HisH HAMAP-Rule MF_00278
EC=2.4.2.- HAMAP-Rule MF_00278
Alternative name(s):
IGP synthase glutamine amidotransferase subunit HAMAP-Rule MF_00278
IGP synthase subunit HisH HAMAP-Rule MF_00278
ImGP synthase subunit HisH HAMAP-Rule MF_00278
Gene names
Name:hisH HAMAP-Rule MF_00278
Ordered Locus Names:Spro_1612 EMBL ABV40716.1
OrganismSerratia proteamaculans (strain 568) [Complete proteome] [HAMAP] EMBL ABV40716.1
Taxonomic identifier399741 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia ›

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR By similarity. SAAS SAAS010139 HAMAP-Rule MF_00278

Catalytic activity

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O. SAAS SAAS010139 HAMAP-Rule MF_00278

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. SAAS SAAS010139 HAMAP-Rule MF_00278

Subunit structure

Heterodimer of HisH and HisF By similarity. SAAS SAAS010139 HAMAP-Rule MF_00278

Subcellular location

Cytoplasm By similarity SAAS SAAS010139 HAMAP-Rule MF_00278.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain. SAAS SAAS010139 HAMAP-Rule MF_00278

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain2 – 196195Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_00278

Sites

Active site771Nucleophile By similarity HAMAP-Rule MF_00278
Active site1781 By similarity HAMAP-Rule MF_00278
Active site1801 By similarity HAMAP-Rule MF_00278

Sequences

Sequence LengthMass (Da)Tools
A8GC76 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: AA53FABB79F79C09

FASTA19621,348
        10         20         30         40         50         60 
MDVVILDTGC ANLASVTYAV QRLGYRPEVS RDPEIVLRAD KLFLPGVGTA QAAMDQLEQR 

        70         80         90        100        110        120 
ELIELIKACT QPVLGICLGM QLLAKSSEEN GGIDTLGIID TPVTQMTDFG LPLPHMGWNQ 

       130        140        150        160        170        180 
VSAQAGHHLF RGIEDGAYFY FVHSYAMPIC PSTIAQANYG EPFTAAVQKD NFFGVQFHPE 

       190 
RSGAAGAQLL KNFLEM

« Hide

References

[1]"Complete sequence of chromosome of Serratia proteamaculans 568."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 568 EMBL ABV40716.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000826 Genomic DNA. Translation: ABV40716.1.
RefSeqYP_001477844.1. NC_009832.1.

3D structure databases

ProteinModelPortalA8GC76.
ModBaseSearch...

Protein-protein interaction databases

STRING399741.Spro_1612.

Protein family/group databases

MEROPSC26.965.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV40716; ABV40716; Spro_1612.
GeneID5603824.
KEGGspe:Spro_1612.
PATRIC32415914. VBISerPro44537_1642.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0118.
HOGENOMHOG000025030.
KOK02501.
OMAYGLGNLR.
ProtClustDBPRK13170.

Enzyme and pathway databases

UniPathwayUPA00031; UER00010.

Family and domain databases

HAMAPMF_00278. HisH.
InterProIPR017926. GATASE_1.
IPR010139. Imidazole-glycPsynth_HisH.
[Graphical view]
PfamPF00117. GATase. 1 hit.
[Graphical view]
PIRSFPIRSF000495. Amidotransf_hisH. 1 hit.
TIGRFAMsTIGR01855. IMP_synth_hisH. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8GC76_SERP5
AccessionPrimary (citable) accession number: A8GC76
Entry history
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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