Reviewed, UniProtKB/Swiss-Prot A8GBX9 (BETA_SERP5)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	Spro_1515

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Choline dehydrogenase		PRO_1000062188
Regions
	Nucleotide binding	4 – 33	30	FAD Probable
Sites
	Active site	473	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8GBX9-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 240B762F344C1823	FASTA	555	61,626
	10 20 30 40 50 60 MEYDYIIIGA GSAGNVLATR LTEDADVSVL LLEAGGPDYR MDFRTQMPAA LAFPLQGRRY 70 80 90 100 110 120 NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN AMDFDNWAKA PGLEDWSYLD 130 140 150 160 170 180 CLPYFRKAET RDIGPNDFHG GDGPVSVTTP KAGNNELFHA MVEAGVQAGY PRTEDLNGYQ 190 200 210 220 230 240 QEGFGPMDRT VTPKGRRAST ARGYLDQARS RPNLKIVTHA LTDRIRFDGK RAVGVDYLQG 250 260 270 280 290 300 EAKDVTSARA RREVLLCAGA IASPQILQRS GVGPAALLNR LDIDLVHELP GVGENLQDHL 310 320 330 340 350 360 EMYLQYACKK PVSLYPALQW FNQPKIGAEW LFNGSGIGAS NQFEAGGFIR SREEFAWPNI 370 380 390 400 410 420 QYHFLPVAIN YNGSNAVKEH GFQAHVGSMR SPSRGRVQVK SKDPRQHPSI LFNYMATEQD 430 440 450 460 470 480 WQEFRDAIRI TREIMAQPAL DEYRGREISP GPEVQTDEQL DAFVREHAET AFHPSCSCKM 490 500 510 520 530 540 GEDEMAVVDG QGRVHGLEGL RVVDASIMPL IITGNLNATT IMIAEKIADR IRQRTPLPRS 550 TAEYYVAGNA PARKQ

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000826 Genomic DNA. Translation: ABV40619.1.
RefSeq	YP_001477747.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5603625.
GenomeReviews	Gene locus Spro_1515 in contig CP000826_GR.
KEGG	spe:Spro_1515.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_SERP5

Accession

Primary (citable) accession number: A8GBX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	November 25, 2008
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)