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A8GBX9

- BETA_SERP5

UniProt

A8GBX9 - BETA_SERP5

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Protein
Oxygen-dependent choline dehydrogenase
Gene
betA, Spro_1515
Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei473 – 4731 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSPRO399741:GI55-1565-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:Spro_1515
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Oxygen-dependent choline dehydrogenaseUniRule annotation
PRO_1000062188Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_1515.

Structurei

3D structure databases

ProteinModelPortaliA8GBX9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GBX9-1 [UniParc]FASTAAdd to Basket

« Hide

MEYDYIIIGA GSAGNVLATR LTEDADVSVL LLEAGGPDYR MDFRTQMPAA    50
LAFPLQGRRY NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN 100
AMDFDNWAKA PGLEDWSYLD CLPYFRKAET RDIGPNDFHG GDGPVSVTTP 150
KAGNNELFHA MVEAGVQAGY PRTEDLNGYQ QEGFGPMDRT VTPKGRRAST 200
ARGYLDQARS RPNLKIVTHA LTDRIRFDGK RAVGVDYLQG EAKDVTSARA 250
RREVLLCAGA IASPQILQRS GVGPAALLNR LDIDLVHELP GVGENLQDHL 300
EMYLQYACKK PVSLYPALQW FNQPKIGAEW LFNGSGIGAS NQFEAGGFIR 350
SREEFAWPNI QYHFLPVAIN YNGSNAVKEH GFQAHVGSMR SPSRGRVQVK 400
SKDPRQHPSI LFNYMATEQD WQEFRDAIRI TREIMAQPAL DEYRGREISP 450
GPEVQTDEQL DAFVREHAET AFHPSCSCKM GEDEMAVVDG QGRVHGLEGL 500
RVVDASIMPL IITGNLNATT IMIAEKIADR IRQRTPLPRS TAEYYVAGNA 550
PARKQ 555
Length:555
Mass (Da):61,626
Last modified:November 13, 2007 - v1
Checksum:i240B762F344C1823
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV40619.1.
RefSeqiYP_001477747.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV40619; ABV40619; Spro_1515.
GeneIDi5603625.
KEGGispe:Spro_1515.
PATRICi32415730. VBISerPro44537_1550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV40619.1 .
RefSeqi YP_001477747.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GBX9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 399741.Spro_1515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV40619 ; ABV40619 ; Spro_1515 .
GeneIDi 5603625.
KEGGi spe:Spro_1515.
PATRICi 32415730. VBISerPro44537_1550.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SPRO399741:GI55-1565-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiBETA_SERP5
AccessioniPrimary (citable) accession number: A8GBX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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