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A8GBX9

- BETA_SERP5

UniProt

A8GBX9 - BETA_SERP5

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei473 – 4731UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSPRO399741:GI55-1565-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:Spro_1515
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Oxygen-dependent choline dehydrogenasePRO_1000062188Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_1515.

Structurei

3D structure databases

ProteinModelPortaliA8GBX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8GBX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYDYIIIGA GSAGNVLATR LTEDADVSVL LLEAGGPDYR MDFRTQMPAA
60 70 80 90 100
LAFPLQGRRY NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN
110 120 130 140 150
AMDFDNWAKA PGLEDWSYLD CLPYFRKAET RDIGPNDFHG GDGPVSVTTP
160 170 180 190 200
KAGNNELFHA MVEAGVQAGY PRTEDLNGYQ QEGFGPMDRT VTPKGRRAST
210 220 230 240 250
ARGYLDQARS RPNLKIVTHA LTDRIRFDGK RAVGVDYLQG EAKDVTSARA
260 270 280 290 300
RREVLLCAGA IASPQILQRS GVGPAALLNR LDIDLVHELP GVGENLQDHL
310 320 330 340 350
EMYLQYACKK PVSLYPALQW FNQPKIGAEW LFNGSGIGAS NQFEAGGFIR
360 370 380 390 400
SREEFAWPNI QYHFLPVAIN YNGSNAVKEH GFQAHVGSMR SPSRGRVQVK
410 420 430 440 450
SKDPRQHPSI LFNYMATEQD WQEFRDAIRI TREIMAQPAL DEYRGREISP
460 470 480 490 500
GPEVQTDEQL DAFVREHAET AFHPSCSCKM GEDEMAVVDG QGRVHGLEGL
510 520 530 540 550
RVVDASIMPL IITGNLNATT IMIAEKIADR IRQRTPLPRS TAEYYVAGNA

PARKQ
Length:555
Mass (Da):61,626
Last modified:November 13, 2007 - v1
Checksum:i240B762F344C1823
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV40619.1.
RefSeqiYP_001477747.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV40619; ABV40619; Spro_1515.
GeneIDi5603625.
KEGGispe:Spro_1515.
PATRICi32415730. VBISerPro44537_1550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV40619.1 .
RefSeqi YP_001477747.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8GBX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399741.Spro_1515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV40619 ; ABV40619 ; Spro_1515 .
GeneIDi 5603625.
KEGGi spe:Spro_1515.
PATRICi 32415730. VBISerPro44537_1550.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SPRO399741:GI55-1565-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiBETA_SERP5
AccessioniPrimary (citable) accession number: A8GBX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3