Reviewed, UniProtKB/Swiss-Prot A8GBX8 (BETB_SERP5)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Spro_1514

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_1000062270
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8GBX8-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 015CD30BF767B0FB	FASTA	490	52,666
	10 20 30 40 50 60 MSRFGLQKLY INGAYVDSTD GKTFNAVNPA NGEVLAEIQS ASAEDVNRAV ASAASGQKVW 70 80 90 100 110 120 AAMTAMARSR ILRRAVDILR ERNDELAALE TLDTGKAMSE TTAVDIVTGA DVLEYYAGLI 130 140 150 160 170 180 PSIEGQQIPL RDTSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTALKLAE IYTEAGLPDG VFNVVTGSGA EVGQYLTDHP GIAKVSFTGG VKTGKKVMAN 250 260 270 280 290 300 ASGSTLKEVT MELGGKSPLI IFDDADLDRA ADIAMMANFY SSGQVCTNGT RVFVPAALQA 310 320 330 340 350 360 QFEAKILERV KRIRLGDPTD PQTNFGPLVS FAHMESVLRF IESGKNSGAR LLCGGERVTE 370 380 390 400 410 420 GEFAKGAYVA PTVFTDCRDE MEIVREEIFG PVMSILSYQS EEEVVRRAND TTFGLAAGVV 430 440 450 460 470 480 TNDLTRAHRV IHQLEAGICW INTWGESAAE MPVGGYKQSG VGRENGLMTL EHYTQIKSVQ 490 VELGEYASVF

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000826 Genomic DNA. Translation: ABV40618.1.
RefSeq	YP_001477746.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5603624.
GenomeReviews	Gene locus Spro_1514 in contig CP000826_GR.
KEGG	spe:Spro_1514.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A8GBX8. TLKEVTM.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_SERP5

Accession

Primary (citable) accession number: A8GBX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	June 16, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)