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A8GBX8 (BETB_SERP5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:Spro_1514
OrganismSerratia proteamaculans (strain 568) [Complete proteome] [HAMAP]
Taxonomic identifier399741 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbetaine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Betaine aldehyde dehydrogenase HAMAP MF_00804
PRO_1000062270

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

Sequences

Sequence LengthMass (Da)Tools
A8GBX8 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 015CD30BF767B0FB

FASTA49052,666
        10         20         30         40         50         60 
MSRFGLQKLY INGAYVDSTD GKTFNAVNPA NGEVLAEIQS ASAEDVNRAV ASAASGQKVW 

        70         80         90        100        110        120 
AAMTAMARSR ILRRAVDILR ERNDELAALE TLDTGKAMSE TTAVDIVTGA DVLEYYAGLI 

       130        140        150        160        170        180 
PSIEGQQIPL RDTSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 

       190        200        210        220        230        240 
TSLTALKLAE IYTEAGLPDG VFNVVTGSGA EVGQYLTDHP GIAKVSFTGG VKTGKKVMAN 

       250        260        270        280        290        300 
ASGSTLKEVT MELGGKSPLI IFDDADLDRA ADIAMMANFY SSGQVCTNGT RVFVPAALQA 

       310        320        330        340        350        360 
QFEAKILERV KRIRLGDPTD PQTNFGPLVS FAHMESVLRF IESGKNSGAR LLCGGERVTE 

       370        380        390        400        410        420 
GEFAKGAYVA PTVFTDCRDE MEIVREEIFG PVMSILSYQS EEEVVRRAND TTFGLAAGVV 

       430        440        450        460        470        480 
TNDLTRAHRV IHQLEAGICW INTWGESAAE MPVGGYKQSG VGRENGLMTL EHYTQIKSVQ 

       490 
VELGEYASVF

« Hide

References

[1]"Complete sequence of chromosome of Serratia proteamaculans 568."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 568.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000826 Genomic DNA. Translation: ABV40618.1.
RefSeqYP_001477746.1. NC_009832.1.

3D structure databases

ProteinModelPortalA8GBX8.
SMRA8GBX8. Positions 8-490.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8GBX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5603624.
GenomeReviewsGene locus Spro_1514 in contig CP000826_GR.
KEGGspe:Spro_1514.
PATRIC32415728. VBISerPro44537_1549.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAGRENGLM.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycSPRO399741:SPRO_1514-MONOMER.

Family and domain databases

HAMAPMF_00804. BADH.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00130.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_SERP5
AccessionPrimary (citable) accession number: A8GBX8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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