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A8GB21

- SYL_SERP5

UniProt

A8GB21 - SYL_SERP5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPRO399741:GI55-1246-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Spro_1207
    OrganismiSerratia proteamaculans (strain 568)
    Taxonomic identifieri399741 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
    ProteomesiUP000007074: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 860860Leucine--tRNA ligasePRO_1000057348Add
    BLAST

    Proteomic databases

    PRIDEiA8GB21.

    Interactioni

    Protein-protein interaction databases

    STRINGi399741.Spro_1207.

    Structurei

    3D structure databases

    ProteinModelPortaliA8GB21.
    SMRiA8GB21. Positions 228-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8GB21-1 [UniParc]FASTAAdd to Basket

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    MQEQYRPEDI ESNVQLHWQE KQTFKVTEDA SKEKYYCLSM LPYPSGRLHM    50
    GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW 100
    TYDNIEYMKN QLKLLGFGYD WDREIATCDP DYYRWEQWFF TKLYEKGLVY 150
    KKTSAVNWCP HDLTVLANEQ VIDGCCWRCD TKVERKEIPQ WFIKITDYAD 200
    QLLNDLDTLE SWPEQVKTMQ RNWIGRSEGV DITFDVAGSD EKLTVYTTRP 250
    DTFMGATYVA VAAGHPLAQQ GAVNNPALAE FIEECRNTKV AEAEMATMEK 300
    KGMPTGLFAI HPLSGEQVPV WVANFVLMEY GTGAVMAVPA HDQRDWEFAT 350
    KYGLPIKPVV LALDGSQPDV QAEAMTEKGT LFNSGEFDGL DHQDGFNAIA 400
    DKLVAKGVGQ RKVNYRLRDW GVSRQRYWGA PIPMVTLEDG TVMPTPEDQL 450
    PVILPEDVVM DGITSPIKAD PEWAKTTVNG QPALRETDTF DTFMESSWYY 500
    ARYTCPQYDK GMLDPAAANY WLPVDQYVGG IEHAIMHLMY FRFFHKLLRD 550
    AGLVDSDEPA KRLLCQGMVL ADAFYYSGNS GERVWVSPAD AIVERDDKGR 600
    IIKATDPQGR ELVYAGMSKM SKSKNNGIDP QVMVEKYGAD TVRLFMMFAS 650
    PAEMTLEWQE SGVEGANRFL KRVWKLSYEH LEKGAVQPLN VATLTEDQKA 700
    LRRDLHKTIA KVTDDIGRRQ TFNTAIAAVM ELMNKLARAP QESEQDRALL 750
    QEALLAVVRM LYPFTPHVCF SLWQALGGEG DVDTAAWPQA DEQAMVEDSK 800
    LVVVQVNGKV RAKITVAADA TEEQVRARAA EEHLVAKYLD GVTVRKVIYV 850
    PGKLLNLVVG 860
    Length:860
    Mass (Da):97,024
    Last modified:November 13, 2007 - v1
    Checksum:iB55556EAA82BE5AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000826 Genomic DNA. Translation: ABV40311.1.
    RefSeqiYP_001477439.1. NC_009832.1.

    Genome annotation databases

    EnsemblBacteriaiABV40311; ABV40311; Spro_1207.
    GeneIDi5602925.
    KEGGispe:Spro_1207.
    PATRICi32415090. VBISerPro44537_1241.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000826 Genomic DNA. Translation: ABV40311.1 .
    RefSeqi YP_001477439.1. NC_009832.1.

    3D structure databases

    ProteinModelPortali A8GB21.
    SMRi A8GB21. Positions 228-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399741.Spro_1207.

    Proteomic databases

    PRIDEi A8GB21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV40311 ; ABV40311 ; Spro_1207 .
    GeneIDi 5602925.
    KEGGi spe:Spro_1207.
    PATRICi 32415090. VBISerPro44537_1241.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SPRO399741:GI55-1246-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 568.

    Entry informationi

    Entry nameiSYL_SERP5
    AccessioniPrimary (citable) accession number: A8GB21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3