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Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: D-glycero-D-manno-heptose 7-phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoheptose isomerase (gmhA)
This subpathway is part of the pathway D-glycero-D-manno-heptose 7-phosphate biosynthesis, which is itself part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate, the pathway D-glycero-D-manno-heptose 7-phosphate biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61ZincUniRule annotation1
Metal bindingi65ZincUniRule annotation1
Binding sitei65SubstrateUniRule annotation1
Binding sitei124SubstrateUniRule annotation1
Metal bindingi172ZincUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Metal bindingi180ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00041; UER00436

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
Alternative name(s):
Sedoheptulose 7-phosphate isomeraseUniRule annotation
Gene namesi
Name:gmhAUniRule annotation
Ordered Locus Names:Spro_0950
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000574531 – 193Phosphoheptose isomeraseAdd BLAST193

Proteomic databases

PRIDEiA8GAB6

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi399741.Spro_0950

Structurei

3D structure databases

ProteinModelPortaliA8GAB6
SMRiA8GAB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 193SISUniRule annotationAdd BLAST157

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 54Substrate bindingUniRule annotation3
Regioni93 – 94Substrate bindingUniRule annotation2
Regioni119 – 121Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F55 Bacteria
COG0279 LUCA
HOGENOMiHOG000237571
KOiK03271
OMAiFLAHKEA
OrthoDBiPOG091H02G7

Family and domain databases

CDDicd05006 SIS_GmhA, 1 hit
HAMAPiMF_00067 GmhA, 1 hit
InterProiView protein in InterPro
IPR035461 GmhA/DiaA
IPR004515 Phosphoheptose_Isoase
IPR001347 SIS
PfamiView protein in Pfam
PF13580 SIS_2, 1 hit
TIGRFAMsiTIGR00441 gmhA, 1 hit
PROSITEiView protein in PROSITE
PS51464 SIS, 1 hit

Sequencei

Sequence statusi: Complete.

A8GAB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHDLIRSEL NEAADTLAKF INDDANIDAI QRAAVLLADS FKAGGKVISC
60 70 80 90 100
GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDVSHLSC VSNDFGYEYV
110 120 130 140 150
FSRYVEAVGR EGDVLLGIST SGNSGNIIKA IEAARAKGMK VITLTGKDGG
160 170 180 190
KMAGSADVEI RVPHFGYADR IQEIHIKAIH ILIQLIEKEM VKA
Length:193
Mass (Da):20,871
Last modified:November 13, 2007 - v1
Checksum:i8316FF11B753BEEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV40056.1
RefSeqiWP_004949058.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV40056; ABV40056; Spro_0950
GeneIDi29902821
KEGGispe:Spro_0950

Similar proteinsi

Entry informationi

Entry nameiGMHA_SERP5
AccessioniPrimary (citable) accession number: A8GAB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome