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Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Divalent metal cationUniRule annotation1
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi39Divalent metal cationUniRule annotation1
Metal bindingi92Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
Alternative name(s):
ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
Nucleoside monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:Spro_0829
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia
Proteomesi
  • UP000007074 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003352691 – 2535'/3'-nucleotidase SurEAdd BLAST253

Proteomic databases

PRIDEiA8G9Z5

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_0829

Structurei

3D structure databases

ProteinModelPortaliA8G9Z5
SMRiA8G9Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CV2 Bacteria
COG0496 LUCA
HOGENOMiHOG000122500
KOiK03787
OMAiDCVHIAL
OrthoDBiPOG091H01CP

Family and domain databases

Gene3Di3.40.1210.10, 1 hit
HAMAPiMF_00060 SurE, 1 hit
InterProiView protein in InterPro
IPR030048 SurE
IPR002828 SurE-like_Pase/nucleotidase
IPR036523 SurE-like_sf
PfamiView protein in Pfam
PF01975 SurE, 1 hit
TIGRFAMsiTIGR00087 surE, 1 hit

Sequencei

Sequence statusi: Complete.

A8G9Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILLSNDDG VTAPGIQVLA AALREFAEVQ VVAPDRNRSG SSNALTLESP
60 70 80 90 100
LRTLTMPNGD IAVQQGTPTD CVYLGVNALM QPAPDIVVSG INAGPNLGDD
110 120 130 140 150
VIYSGTVAAA MEGRHLGLPA LAVSLNGHQH YATAAAITCR VLRALQREPL
160 170 180 190 200
RTGKILNINV PDLPLDQIKG IRVTRCGSRH PADKVFCQQD PRGQNLYWIG
210 220 230 240 250
PPGDKFDAGP DTDFAAVEQG YVAITPLQVD LTAYAAQDVV KTWLTKAGVG

GEW
Length:253
Mass (Da):26,842
Last modified:November 13, 2007 - v1
Checksum:iCC6B502A1B030085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA Translation: ABV39935.1
RefSeqiWP_012005277.1, NC_009832.1

Genome annotation databases

EnsemblBacteriaiABV39935; ABV39935; Spro_0829
KEGGispe:Spro_0829

Similar proteinsi

Entry informationi

Entry nameiSURE_SERP5
AccessioniPrimary (citable) accession number: A8G9Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health