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A8G9Z5

- SURE_SERP5

UniProt

A8G9Z5 - SURE_SERP5

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Protein

5'/3'-nucleotidase SurE

Gene
surE, Spro_0829
Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs By similarity.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Divalent metal cation By similarity
Metal bindingi9 – 91Divalent metal cation By similarity
Metal bindingi39 – 391Divalent metal cation By similarity
Metal bindingi92 – 921Divalent metal cation By similarity

GO - Molecular functioni

  1. 3'-nucleotidase activity Source: UniProtKB-HAMAP
  2. 5'-nucleotidase activity Source: UniProtKB-HAMAP
  3. exopolyphosphatase activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-HAMAP
  5. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPRO399741:GI55-857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
5'/3'-nucleotidase SurE (EC:3.1.3.5, EC:3.1.3.6)
Alternative name(s):
Exopolyphosphatase (EC:3.6.1.11)
Nucleoside monophosphate phosphohydrolase
Gene namesi
Name:surE
Ordered Locus Names:Spro_0829
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2532535'/3'-nucleotidase SurEUniRule annotationPRO_0000335269Add
BLAST

Proteomic databases

PRIDEiA8G9Z5.

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_0829.

Structurei

3D structure databases

ProteinModelPortaliA8G9Z5.

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.

Phylogenomic databases

eggNOGiCOG0496.
HOGENOMiHOG000122500.
KOiK03787.
OMAiVCDLIPK.
OrthoDBiEOG68WR45.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE.
InterProiIPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

A8G9Z5-1 [UniParc]FASTAAdd to Basket

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MRILLSNDDG VTAPGIQVLA AALREFAEVQ VVAPDRNRSG SSNALTLESP    50
LRTLTMPNGD IAVQQGTPTD CVYLGVNALM QPAPDIVVSG INAGPNLGDD 100
VIYSGTVAAA MEGRHLGLPA LAVSLNGHQH YATAAAITCR VLRALQREPL 150
RTGKILNINV PDLPLDQIKG IRVTRCGSRH PADKVFCQQD PRGQNLYWIG 200
PPGDKFDAGP DTDFAAVEQG YVAITPLQVD LTAYAAQDVV KTWLTKAGVG 250
GEW 253
Length:253
Mass (Da):26,842
Last modified:November 13, 2007 - v1
Checksum:iCC6B502A1B030085
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV39935.1.
RefSeqiYP_001477063.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV39935; ABV39935; Spro_0829.
GeneIDi5603034.
KEGGispe:Spro_0829.
PATRICi32414302. VBISerPro44537_0858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000826 Genomic DNA. Translation: ABV39935.1 .
RefSeqi YP_001477063.1. NC_009832.1.

3D structure databases

ProteinModelPortali A8G9Z5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399741.Spro_0829.

Proteomic databases

PRIDEi A8G9Z5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV39935 ; ABV39935 ; Spro_0829 .
GeneIDi 5603034.
KEGGi spe:Spro_0829.
PATRICi 32414302. VBISerPro44537_0858.

Phylogenomic databases

eggNOGi COG0496.
HOGENOMi HOG000122500.
KOi K03787.
OMAi VCDLIPK.
OrthoDBi EOG68WR45.

Enzyme and pathway databases

BioCyci SPRO399741:GI55-857-MONOMER.

Family and domain databases

Gene3Di 3.40.1210.10. 1 hit.
HAMAPi MF_00060. SurE.
InterProi IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view ]
Pfami PF01975. SurE. 1 hit.
[Graphical view ]
SUPFAMi SSF64167. SSF64167. 1 hit.
TIGRFAMsi TIGR00087. surE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiSURE_SERP5
AccessioniPrimary (citable) accession number: A8G9Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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