A8G9G5 (RSMC_SERP5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase C
EC=2.1.1.172

Alternative name(s):
16S rRNA m2G1207 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RsmC

Gene names

Name:	rsmC
Ordered Locus Names:	Spro_0649

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the guanosine in position 1207 of 16S rRNA in the 30S particle By similarity. HAMAP MF_01862
Catalytic activity	S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanosine(1207) in 16S rRNA. HAMAP MF_01862
Subunit structure	Monomer By similarity. HAMAP MF_01862
Subcellular location	Cytoplasm Potential HAMAP MF_01862.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmC family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro rRNA (guanine-N2-)-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Ribosomal RNA small subunit methyltransferase C HAMAP MF_01862		PRO_0000369765

Sequences

	Sequence		Length	Mass (Da)
	A8G9G5 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 98742F2AB5CE8538	FASTA	347	38,139
	10 20 30 40 50 60 MSALTPASEV MLRHSDEFIE RRVLFAGDLQ DALPAQFEAA DVRVHTQQYH HWQLLNRAMG 70 80 90 100 110 120 DNVQYGLTVD AAFVAECDTL IYYWPKSKQE AQFQLCNILA LLPVGTDVFV VGENRSGVRS 130 140 150 160 170 180 ADQMVEDYAT LVKIDSARRC GLYHGRLDTQ TEFNLEDWWE SYQLHDLEVK TLPGVFSRDG 190 200 210 220 230 240 LDVGSSLLLS TLDKHMKGKV LDVGCGAGVM ASVLSKLSPK MKLTLSDVNA AAIESSRATL 250 260 270 280 290 300 AANGIEGEVI VSNVYSDITG RFDLIISNPP FHDGLQTSLT AAETLIRGAL KHLGVGGKLR 310 320 330 340 IVANAFLPYP DILDATFGSH EVLAQNGRFK VYQATVARAP RDAKKKK

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 568.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000826 Genomic DNA. Translation: ABV39755.1.
RefSeq	YP_001476883.1. NC_009832.1.
3D structure databases
ProteinModelPortal	A8G9G5.
SMR	A8G9G5. Positions 3-334.
ModBase	Search...
Protein-protein interaction databases
STRING	A8G9G5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5605798.
GenomeReviews	Gene locus Spro_0649 in contig CP000826_GR.
KEGG	spe:Spro_0649.
PATRIC	32413934. VBISerPro44537_0674.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2813.
HOGENOM	HBG296757.
OMA	TGKFKVY.
ProtClustDB	PRK09489.
Enzyme and pathway databases
BioCyc	SPRO399741:SPRO_0649-MONOMER.
Family and domain databases
HAMAP	MF_01862. 16SrRNA_methyltr_C. [Tree]
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR013675. Mtase_sm_N. IPR023543. rRNA_ssu_MeTfrase_C. IPR007848. Small_mtfrase. [Graphical view]
KO	K00564.
Pfam	PF05175. MTS. 1 hit. PF08468. MTS_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMC_SERP5

Accession

Primary (citable) accession number: A8G9G5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program