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A8G827 (GPPA_SERP5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:Spro_0157
OrganismSerratia proteamaculans (strain 568) [Complete proteome] [HAMAP]
Taxonomic identifier399741 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_1000068824

Sequences

Sequence LengthMass (Da)Tools
A8G827 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 0AD1CDF3CD2DE489

FASTA49855,773
        10         20         30         40         50         60 
MLSSSALYAA IDLGSNSFHM LVVREVAGSI QTLARIKRKV RLAAGLDQNN LLSHEAMQRG 

        70         80         90        100        110        120 
WQCLKLFSER LQDIPRAQIR VVATATLRLA SNADEFLQTA EQILGCPIQV ISGEEEARLI 

       130        140        150        160        170        180 
YHGVAHTTGG PDQRLVVDIG GGSTELVTGT GAQAAQLYSL SMGCVTWLER FFSDRNLGQE 

       190        200        210        220        230        240 
NFERAEQAAR EMVRPIAPQL RQHGWQVCVG ASGTVQALQE IMVAQGMDER ITLSKLRQLK 

       250        260        270        280        290        300 
QRAIQCGKLE ELEIEGLTLE RALVFPSGLS ILLAIFQELG IESMMLAGGA LREGLVYGML 

       310        320        330        340        350        360 
HLPVEQDIRS RTIRNLQRRY LLDTEQAERV SQLAANFSQQ VSNEWQLDAR CRELLHSACL 

       370        380        390        400        410        420 
IHEIGLSVDF KQAPQHAAYL IRHLDLPGFT PAQKKLLATL LQNQSNTIDL PLLSQQNALP 

       430        440        450        460        470        480 
PRTAQRLCRI LRLAIIFASR RRDDTLPAVR LRANNDDELT VILPPGWLEQ HPLRAEALDQ 

       490 
ESHWQSYVHW PLILEEQR 

« Hide

References

[1]"Complete sequence of chromosome of Serratia proteamaculans 568."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 568.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000826 Genomic DNA. Translation: ABV39267.1.
RefSeqYP_001476395.1. NC_009832.1.

3D structure databases

ProteinModelPortalA8G827.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399741.Spro_0157.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV39267; ABV39267; Spro_0157.
GeneID5605156.
KEGGspe:Spro_0157.
PATRIC32412924. VBISerPro44537_0197.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAGLHIEYK.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

BioCycSPRO399741:GI55-159-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsTIGR03706. exo_poly_only. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGPPA_SERP5
AccessionPrimary (citable) accession number: A8G827
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways