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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSPRO399741:GI55-159-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:Spro_0157
OrganismiSerratia proteamaculans (strain 568)
Taxonomic identifieri399741 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
ProteomesiUP000007074 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000068824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399741.Spro_0157.

Structurei

3D structure databases

ProteinModelPortaliA8G827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiFKRAPQH.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
IPR030673. PyroPPase_GppA_Ppx.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
PIRSFiPIRSF001267. Pyrophosphatase_GppA_Ppx. 1 hit.
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

A8G827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSSALYAA IDLGSNSFHM LVVREVAGSI QTLARIKRKV RLAAGLDQNN
60 70 80 90 100
LLSHEAMQRG WQCLKLFSER LQDIPRAQIR VVATATLRLA SNADEFLQTA
110 120 130 140 150
EQILGCPIQV ISGEEEARLI YHGVAHTTGG PDQRLVVDIG GGSTELVTGT
160 170 180 190 200
GAQAAQLYSL SMGCVTWLER FFSDRNLGQE NFERAEQAAR EMVRPIAPQL
210 220 230 240 250
RQHGWQVCVG ASGTVQALQE IMVAQGMDER ITLSKLRQLK QRAIQCGKLE
260 270 280 290 300
ELEIEGLTLE RALVFPSGLS ILLAIFQELG IESMMLAGGA LREGLVYGML
310 320 330 340 350
HLPVEQDIRS RTIRNLQRRY LLDTEQAERV SQLAANFSQQ VSNEWQLDAR
360 370 380 390 400
CRELLHSACL IHEIGLSVDF KQAPQHAAYL IRHLDLPGFT PAQKKLLATL
410 420 430 440 450
LQNQSNTIDL PLLSQQNALP PRTAQRLCRI LRLAIIFASR RRDDTLPAVR
460 470 480 490
LRANNDDELT VILPPGWLEQ HPLRAEALDQ ESHWQSYVHW PLILEEQR
Length:498
Mass (Da):55,773
Last modified:November 13, 2007 - v1
Checksum:i0AD1CDF3CD2DE489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV39267.1.
RefSeqiWP_012004629.1. NC_009832.1.
YP_001476395.1. NC_009832.1.

Genome annotation databases

EnsemblBacteriaiABV39267; ABV39267; Spro_0157.
KEGGispe:Spro_0157.
PATRICi32412924. VBISerPro44537_0197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000826 Genomic DNA. Translation: ABV39267.1.
RefSeqiWP_012004629.1. NC_009832.1.
YP_001476395.1. NC_009832.1.

3D structure databases

ProteinModelPortaliA8G827.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399741.Spro_0157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV39267; ABV39267; Spro_0157.
KEGGispe:Spro_0157.
PATRICi32412924. VBISerPro44537_0197.

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiFKRAPQH.
OrthoDBiEOG6M6JN6.

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.
BioCyciSPRO399741:GI55-159-MONOMER.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
IPR030673. PyroPPase_GppA_Ppx.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
PIRSFiPIRSF001267. Pyrophosphatase_GppA_Ppx. 1 hit.
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 568.

Entry informationi

Entry nameiGPPA_SERP5
AccessioniPrimary (citable) accession number: A8G827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 27, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.