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A8G827

- GPPA_SERP5

UniProt

A8G827 - GPPA_SERP5

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Serratia proteamaculans (strain 568)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. exopolyphosphatase activity Source: InterPro
    2. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
    3. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
    3. polyphosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSPRO399741:GI55-159-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:Spro_0157
    OrganismiSerratia proteamaculans (strain 568)
    Taxonomic identifieri399741 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia
    ProteomesiUP000007074: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000068824Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399741.Spro_0157.

    Structurei

    3D structure databases

    ProteinModelPortaliA8G827.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR022371. Exopolyphosphatase.
    IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8G827-1 [UniParc]FASTAAdd to Basket

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    MLSSSALYAA IDLGSNSFHM LVVREVAGSI QTLARIKRKV RLAAGLDQNN    50
    LLSHEAMQRG WQCLKLFSER LQDIPRAQIR VVATATLRLA SNADEFLQTA 100
    EQILGCPIQV ISGEEEARLI YHGVAHTTGG PDQRLVVDIG GGSTELVTGT 150
    GAQAAQLYSL SMGCVTWLER FFSDRNLGQE NFERAEQAAR EMVRPIAPQL 200
    RQHGWQVCVG ASGTVQALQE IMVAQGMDER ITLSKLRQLK QRAIQCGKLE 250
    ELEIEGLTLE RALVFPSGLS ILLAIFQELG IESMMLAGGA LREGLVYGML 300
    HLPVEQDIRS RTIRNLQRRY LLDTEQAERV SQLAANFSQQ VSNEWQLDAR 350
    CRELLHSACL IHEIGLSVDF KQAPQHAAYL IRHLDLPGFT PAQKKLLATL 400
    LQNQSNTIDL PLLSQQNALP PRTAQRLCRI LRLAIIFASR RRDDTLPAVR 450
    LRANNDDELT VILPPGWLEQ HPLRAEALDQ ESHWQSYVHW PLILEEQR 498
    Length:498
    Mass (Da):55,773
    Last modified:November 13, 2007 - v1
    Checksum:i0AD1CDF3CD2DE489
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000826 Genomic DNA. Translation: ABV39267.1.
    RefSeqiYP_001476395.1. NC_009832.1.

    Genome annotation databases

    EnsemblBacteriaiABV39267; ABV39267; Spro_0157.
    GeneIDi5605156.
    KEGGispe:Spro_0157.
    PATRICi32412924. VBISerPro44537_0197.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000826 Genomic DNA. Translation: ABV39267.1 .
    RefSeqi YP_001476395.1. NC_009832.1.

    3D structure databases

    ProteinModelPortali A8G827.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399741.Spro_0157.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV39267 ; ABV39267 ; Spro_0157 .
    GeneIDi 5605156.
    KEGGi spe:Spro_0157.
    PATRICi 32412924. VBISerPro44537_0197.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci SPRO399741:GI55-159-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR022371. Exopolyphosphatase.
    IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 568.

    Entry informationi

    Entry nameiGPPA_SERP5
    AccessioniPrimary (citable) accession number: A8G827
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3