Reviewed, UniProtKB/Swiss-Prot A8G7U3 (MTLD_SERP5)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	Spro_0073

Organism

Serratia proteamaculans (strain 568) [Complete proteome] [HAMAP]

Taxonomic identifier

399741 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	Mannitol-1-phosphate 5-dehydrogenase		PRO_1000058533
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8G7U3-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 7D1A046FE5AC5CB2	FASTA	383	41,382
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGKLL ADAQAELTFA DVNQTVLDLL NSRKSYQVHV VGEQARVEQV 70 80 90 100 110 120 NNVSAVNSGS EEAVALIAEA DIVTTAVGPQ ILAKIAGTIA KGLSKRHQQG NSQPLNIIAC 130 140 150 160 170 180 ENMVRGTSQL KQHVFDVLPQ EDQAWALQHV GFVDSAVDRI VPPAEAGSSD PLEVTVETFS 190 200 210 220 230 240 EWIVDQTQFK GQPPAIAGME LTDNLMAFVE RKLFTLNTGH AITAYLGQQA GLQTIRDAIL 250 260 270 280 290 300 DPKIRQVVKG AMEESGAVLI KRYGFDAAKH AAYIDKILSR FENPYLHDDV ERVGRQPLRK 310 320 330 340 350 360 LSAGDRLIKP LLGTLEYGLP HANLIQGIAA AMSYRSEQDP QAKELVELLA KLGPKAALAQ 370 380 ISGLPAESEV VEQAVAVYNA MQK

References

[1]

"Complete sequence of chromosome of Serratia proteamaculans 568." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000826 Genomic DNA. Translation: ABV39183.1.
RefSeq	YP_001476311.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5606298.
GenomeReviews	Gene locus Spro_0073 in contig CP000826_GR.
KEGG	spe:Spro_0073.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_SERP5

Accession

Primary (citable) accession number: A8G7U3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	November 25, 2008
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)