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A8G731

- A8G731_PROM2

UniProt

A8G731 - A8G731_PROM2

Protein

Alanine racemase

Gene

alr

Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei59 – 591Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation
    Active sitei291 – 2911Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei339 – 3391Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPMAR93060:GI08-1857-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:P9215_17991Imported
    OrganismiProchlorococcus marinus (strain MIT 9215)Imported
    Taxonomic identifieri93060 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002014: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei59 – 591N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi93060.P9215_17991.

    Structurei

    3D structure databases

    ProteinModelPortaliA8G731.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiKSNTIPW.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8G731-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQIRQINKRF NFDKYQTFNQ DINPKQRAWI EVKGKALEIN VRQLRTKLSK    50
    NCQFMAVVKA DGYGHDAKVV SDYAIRGGAS QLGVATLKEG IKLRSFGVKK 100
    PILILGNLYT KKDLIISFKN DLMPTISSIR ECFICNNIGK HFGLKFSLHL 150
    KVDTGMSRLG FESNKFVQQF EKIKSLENIS IDGIYSHLSS ADAENALDPQ 200
    SITQLQRLKF NQLLKQINLD RNNEIKIHLA NSAGMLLNKD FHFNMVRVGL 250
    SMYGYSPLAK IDKNLLLKPA LFLKVKVAFI RIIEPGVSVS YGGKFVSSRK 300
    TKLAVLSIGY ADGVPRNLSG KINVIHNNKL YPQVGSITMD QMMVDITGSN 350
    EIRIGSTMVL LGSDGDKTIS PLEWATKSNT IPWEILCSFK NRLPRVQVD 399
    Length:399
    Mass (Da):44,845
    Last modified:November 13, 2007 - v1
    Checksum:i1CD764BE2BFA8866
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000825 Genomic DNA. Translation: ABV51412.1.
    RefSeqiWP_012008425.1. NC_009840.1.
    YP_001484998.1. NC_009840.1.

    Genome annotation databases

    EnsemblBacteriaiABV51412; ABV51412; P9215_17991.
    GeneIDi5616218.
    KEGGipmh:P9215_17991.
    PATRICi22993200. VBIProMar119824_1858.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000825 Genomic DNA. Translation: ABV51412.1 .
    RefSeqi WP_012008425.1. NC_009840.1.
    YP_001484998.1. NC_009840.1.

    3D structure databases

    ProteinModelPortali A8G731.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93060.P9215_17991.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV51412 ; ABV51412 ; P9215_17991 .
    GeneIDi 5616218.
    KEGGi pmh:P9215_17991.
    PATRICi 22993200. VBIProMar119824_1858.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi KSNTIPW.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci PMAR93060:GI08-1857-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9215Imported.

    Entry informationi

    Entry nameiA8G731_PROM2
    AccessioniPrimary (citable) accession number: A8G731
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3