A8G6E5 (A8G6E5_PROM2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthetase EMBL ABV51176.1
EC=2.4.1.182 EMBL ABV51176.1

Gene names

Name:	lpxB EMBL ABV51176.1
Ordered Locus Names:	P9215_15631

Organism

Prochlorococcus marinus (strain MIT 9215) [Complete proteome] [HAMAP]

Taxonomic identifier

93060 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL ABV51176.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8G6E5 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 5FCEF2748126232E	FASTA	392	44,764
	10 20 30 40 50 60 MNKKIFISTG EVSGDLHGSL LSKALLDEAK KKSIDLEICG LGGERMKKEG VKILQDTTSI 70 80 90 100 110 120 SAIGIWEALP LILPTIRIQK RFYKLLKNYP PDCLILIDYM GPNIKIGTKL KRSKTKIPIY 130 140 150 160 170 180 YYIAPQEWAW RVGNNTTTNL IKFSDKIFAI FKKEAAFYKK RGGNVLWVGH PMIDLTRKLP 190 200 210 220 230 240 LKKNARTILN LRSSQNILLL MPASRPQELR YVLPTFMRAA KQLQQKYPSL VVYIPSCRRA 250 260 270 280 290 300 FDEIFKKALS KYQVKGIVIS QKDSAKLKPY IYSLTKIAFC KSGTVNMELA LYGIPQIVGY 310 320 330 340 350 360 RVSRITAFIA KKILNFKVRF ISPVNLLVNK LIIPEFVQKN FDEKKIFHKS CRILEGKSEK 370 380 390 IKIKKGYAFL KKELGEEGVV QRAAKDIINS II

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000825 Genomic DNA. Translation: ABV51176.1.
RefSeq	YP_001484762.1. NC_009840.1.
3D structure databases
ProteinModelPortal	A8G6E5.
ModBase	Search...
Protein-protein interaction databases
STRING	A8G6E5.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5615756.
GenomeReviews	Gene locus P9215_15631 in contig CP000825_GR.
KEGG	pmh:P9215_15631.
PATRIC	22992708. VBIProMar119824_1615.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	PDFNLGL.
PhylomeDB	A8G6E5.
ProtClustDB	PRK00025.
Enzyme and pathway databases
BioCyc	PMAR93060:P9215_15631-MONOMER.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8G6E5_PROM2

Accession

Primary (citable) accession number: A8G6E5

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)