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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16SubstrateUniRule annotation1
Binding sitei37SubstrateUniRule annotation1
Active sitei66Proton donorUniRule annotation1
Binding sitei128SubstrateUniRule annotation1
Binding sitei190SubstrateUniRule annotation1
Binding sitei199SubstrateUniRule annotation1
Binding sitei219Substrate; via amide nitrogenUniRule annotation1
Binding sitei220SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciPMAR93060:G1GA0-1509-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:P9215_15571
OrganismiProchlorococcus marinus (strain MIT 9215)
Taxonomic identifieri93060 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000659281 – 242Orotidine 5'-phosphate decarboxylaseAdd BLAST242

Proteomic databases

PRIDEiA8G6D9

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi93060.P9215_15571

Structurei

3D structure databases

ProteinModelPortaliA8G6D9
SMRiA8G6D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 73Substrate bindingUniRule annotation10

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106EG9 Bacteria
COG0284 LUCA
HOGENOMiHOG000226071
KOiK01591
OMAiNFKIFLD
OrthoDBiPOG091H0256

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_B OMPdecase_type1_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

A8G6D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKRFNSEDK IILAIDGLDV SQAKLLLEEC PNIKWVKVGL ELFVREGPRV
60 70 80 90 100
IEILKGLNKK IFLDLKFHDI PNTMRAACSQ VSKLGVDIIS IHASAGLKAL
110 120 130 140 150
KDSKKASLEG ATSVSVKPPL VVGITVLTSF SLKDFQTDLD RNNSIEENVL
160 170 180 190 200
RLAKLSFDAG LDGCVCSPWE AKMLRSIYKD NFELITPGIR LNIDNKDDQN
210 220 230 240
RIMTPSEAID NGASKLVIGR SISKAIDPNK ALIEIFKSID SD
Length:242
Mass (Da):26,679
Last modified:November 13, 2007 - v1
Checksum:i0D6EA458FFDC484F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000825 Genomic DNA Translation: ABV51170.1
RefSeqiWP_012008212.1, NC_009840.1

Genome annotation databases

EnsemblBacteriaiABV51170; ABV51170; P9215_15571
KEGGipmh:P9215_15571

Similar proteinsi

Entry informationi

Entry nameiPYRF_PROM2
AccessioniPrimary (citable) accession number: A8G6D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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