A8G5W1 (SYGA_PROM2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine--tRNA ligase alpha subunit
EC=6.1.1.14

Alternative name(s):
Glycyl-tRNA synthetase alpha subunit
Short name=GlyRS

Gene names

Name:	glyQ
Ordered Locus Names:	P9215_13771

Organism

Prochlorococcus marinus (strain MIT 9215) [Complete proteome] [HAMAP]

Taxonomic identifier

93060 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). HAMAP MF_00254
Subunit structure	Tetramer of two alpha and two beta subunits By similarity.
Subcellular location	Cytoplasm HAMAP MF_00254.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Glycine--tRNA ligase alpha subunit HAMAP MF_00254		PRO_1000059055

Sequences

	Sequence		Length	Mass (Da)
	A8G5W1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: AFAB4E5BFC8CEB38	FASTA	295	34,498
	10 20 30 40 50 60 MFFQDIIKNL NNFWSEEGCL IMQPYDTEKG AGTMNPHTFL RAIGPEPWSV AYTEPCRRPA 70 80 90 100 110 120 DGRFGDNPNR AQHYFQYQVI IKPSPEGIQE KYLTSLDSLG INPRNHDIRF VEDNWESPTL 130 140 150 160 170 180 GAWGVGWEVW LDGMEVTQFT YFQQCGGIDC KPIPIEITYG LERIAMFLQD KESIWDLNWN 190 200 210 220 230 240 RDLKYSDIWL QFEKSQCSYN FKESSADNLR KLFEIYQSEA ISLIEKKLTY PALDFVLKCS 250 260 270 280 290 HNFNLLDARG VISVTDRAQY IEKIRKLARE VASSWIDERE SLHFPLMKNS KEIFL

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9215.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000825 Genomic DNA. Translation: ABV50992.1.
RefSeq	YP_001484578.1. NC_009840.1.
3D structure databases
ProteinModelPortal	A8G5W1.
SMR	A8G5W1. Positions 1-281.
ModBase	Search...
Protein-protein interaction databases
STRING	A8G5W1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5616428.
GenomeReviews	Gene locus P9215_13771 in contig CP000825_GR.
KEGG	pmh:P9215_13771.
PATRIC	22992306. VBIProMar119824_1420.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0752.
HOGENOM	HBG285316.
OMA	CRRPTDG.
PhylomeDB	A8G5W1.
ProtClustDB	PRK09348.
Enzyme and pathway databases
BioCyc	PMAR93060:P9215_13771-MONOMER.
Family and domain databases
HAMAP	MF_00254. Gly_tRNA_synth_alpha. [Tree]
InterPro	IPR006194. Gly-tRNA-synth_II_heterodimer. IPR002310. Gly-tRNA_synth_IIc_asu. [Graphical view]
KO	K01878.
Pfam	PF02091. tRNA-synt_2e. 1 hit. [Graphical view]
PRINTS	PR01044. TRNASYNTHGA.
TIGRFAMs	TIGR00388. GlyQ. 1 hit.
PROSITE	PS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYGA_PROM2

Accession

Primary (citable) accession number: A8G5W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program