A8G5D2 (A8G5D2_PROM2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL ABV50813.1
Ordered Locus Names:	P9215_11981

Organism

Prochlorococcus marinus (strain MIT 9215) [Complete proteome] [HAMAP]

Taxonomic identifier

93060 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	865 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS013760 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8G5D2 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 447FD17DD999EFC7	FASTA	865	96,316
	10 20 30 40 50 60 MSDILDSDNS GLSEDNDRII QTDLRNEMSR SYLEYAMSVI VGRALPDARD GLKPVHRRIL 70 80 90 100 110 120 YAMYELGLTS GRPYRKCARV VGEVLGKYHP HGDTAVYDAL VRMAQDFSMR MPLIDGHGNF 130 140 150 160 170 180 GSVDNDPPAA MRYTESRLQS LTDESLLEDI ESETVDFSDN FDGSQQEPTV LPARIPQLLL 190 200 210 220 230 240 NGSSGIAVGM ATNIPPHNLG ELINGLKSII KNPSIEDREL FEIIKGPDFP TGGQILGREG 250 260 270 280 290 300 IRETFKTGKG SITMRGVANI EQIKSIGRAE KDAVIITELP FQTNKAALIE RIADLVNEKK 310 320 330 340 350 360 LEGISDIRDE SDRDGMRIVI ELKRDSYPQV VLNNLFKLTP LQNNFSANIL ALVKGEPTTL 370 380 390 400 410 420 SLRKMLDVFL DFRVETIRRR TAFLLKKAEE RDHIVKGLLL ALDAMDEIIN LIRSAKDSIS 430 440 450 460 470 480 AREKLQNEHK LSSIQSDAIL QMQLRRLTAL EADKIKEEHN ELTRKINLYQ QILNSKERIF 490 500 510 520 530 540 EIILEELNQI DGKFSSPRKT EILDLGGGLD DIDLIANDRS VVLLTEAGYL KRMPVNDFES 550 560 570 580 590 600 TSRGSRGKAG TKTKEDDDVK LFISCNDHDT LLLFSDRGVA YALPAYRVPM SSRTAKGTPS 610 620 630 640 650 660 VQLLPIPREE KITSLVAVDS FVDDRYLLML TKAGFIKRTA LSAFSKIRSN GLIAINLEDG 670 680 690 700 710 720 DALTWVRLSK EGDSVLIGSK TGIAIHFRLD INELRPLGRT ARGVKSMNLR EGDNLVSMDV 730 740 750 760 770 780 LTSNLVDQLA KIEDLTEDLD DNVEENSSDG PWVLIASAFG LGKRVPVAQF RLQKRAGMGL 790 800 810 820 830 840 RAIKFRIKDD QLVCLKVLGE GEELLLVTEK GVIVRTNADK ISQQSRAATG VKLQRLDDGD 850 860 HLSEVVLVPR EQIEGKDQHG SVEQN

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000825 Genomic DNA. Translation: ABV50813.1.
RefSeq	YP_001484399.1. NC_009840.1.
3D structure databases
ProteinModelPortal	A8G5D2.
ModBase	Search...
Protein-protein interaction databases
STRING	A8G5D2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5615611.
GenomeReviews	Gene locus P9215_11981 in contig CP000825_GR.
KEGG	pmh:P9215_11981.
PATRIC	22991894. VBIProMar119824_1218.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	VCLKVLG.
PhylomeDB	A8G5D2.
ProtClustDB	PRK05560.
Enzyme and pathway databases
BioCyc	PMAR93060:P9215_11981-MONOMER.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 2 hits.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8G5D2_PROM2

Accession

Primary (citable) accession number: A8G5D2

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)