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A8G4T7

- SYL_PROM2

UniProt

A8G4T7 - SYL_PROM2

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Protein
Leucine--tRNA ligase
Gene
leuS, P9215_10031
Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR93060:GI08-1034-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:P9215_10031
OrganismiProchlorococcus marinus (strain MIT 9215)
Taxonomic identifieri93060 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002014: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Leucine--tRNA ligaseUniRule annotation
PRO_1000057346Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93060.P9215_10031.

Structurei

3D structure databases

ProteinModelPortaliA8G4T7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 6311"HIGH" regionUniRule annotation
Add
BLAST
Motifi622 – 6265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVHRQSWP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8G4T7-1 [UniParc]FASTAAdd to Basket

« Hide

MISPDKQYES FTNLYNPSEI EKKWQLIWTE NNLYKTDELT ENSDKFYALS    50
MFPYPSGNLH MGHVRNYVIT DLIARFHRFK GKSVLHPMGW DAFGLPAENA 100
AIERGISPSV WTKQNISHMR SQLKLLGLSV DWDREFATCD ENYYIWTQYL 150
FLELYKAGLV YQKESEVNWD PVDNTVLANE QVDSEGKSWR SGAVVEKKLL 200
KQWFLRITNY ADELLKDLEK LDNWPERVKI MQDNWIGKSI GTNINFNLNT 250
NPEEKITVFT TRPDTLFGVT YLAISVNHSL IKYISDQETI QDIENLKQYL 300
KNNKNNELEK IGIKTSLIAI NPINSEPIPI WVASYVLDEY GTGAVMGVPA 350
HDQRDFEFAK KNNIDIKQVI INDKSEKTNE LDKAYVENGY LMNSDQYNFM 400
ENTIAKLKIS EEGVDNGWAE NKIQYRLRDW LISRQRYWGC PIPIVNCKKC 450
GSVPLKQSEL PVALPKDIDI SANKINALGD NNHWINTTCP KCGIAAKKET 500
DTMDTFMCSS WYFLRYPSSK CSNKPFEKIE INKWLPVDQY VGGVEHAILH 550
LLYARFFTKA LRDNELFEID EPFKKLLTQG MVQAAAYKNN KTGKYVSPSD 600
INDLSNPTDP IDNTKLEVLF EKMSKSKYNG IDPESVIKKY GADTARMFIL 650
FKAPPEKDLE WGDTDVEGQF RFLNRIWKLY INCAKDINSK SNSYPDREKS 700
LIKSMNIAIK EISNDILNNQ FNTAISELMK FYNSLANSIN DVNNTLKIEA 750
LKTFCILLAP FAPHIAEEIW HLIGFKKSVH LEYWPSFNAE ALKEDSYELV 800
IQVNGKVRDK VKINNDMSED QIKELTLKRP NILKWTQDKE IRKIIIVKGK 850
IINIVV 856
Length:856
Mass (Da):98,952
Last modified:November 13, 2007 - v1
Checksum:iCB977FD2125F5D68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV50618.1.
RefSeqiWP_012007705.1. NC_009840.1.
YP_001484204.1. NC_009840.1.

Genome annotation databases

EnsemblBacteriaiABV50618; ABV50618; P9215_10031.
GeneIDi5615845.
KEGGipmh:P9215_10031.
PATRICi22991502. VBIProMar119824_1023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV50618.1 .
RefSeqi WP_012007705.1. NC_009840.1.
YP_001484204.1. NC_009840.1.

3D structure databases

ProteinModelPortali A8G4T7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93060.P9215_10031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV50618 ; ABV50618 ; P9215_10031 .
GeneIDi 5615845.
KEGGi pmh:P9215_10031.
PATRICi 22991502. VBIProMar119824_1023.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VHRQSWP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMAR93060:GI08-1034-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9215.

Entry informationi

Entry nameiSYL_PROM2
AccessioniPrimary (citable) accession number: A8G4T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi