Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A8G4T7

- SYL_PROM2

UniProt

A8G4T7 - SYL_PROM2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR93060:GI08-1034-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:P9215_10031
    OrganismiProchlorococcus marinus (strain MIT 9215)
    Taxonomic identifieri93060 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002014: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 856856Leucine--tRNA ligasePRO_1000057346Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi93060.P9215_10031.

    Structurei

    3D structure databases

    ProteinModelPortaliA8G4T7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi53 – 6311"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVHRQSWP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8G4T7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISPDKQYES FTNLYNPSEI EKKWQLIWTE NNLYKTDELT ENSDKFYALS    50
    MFPYPSGNLH MGHVRNYVIT DLIARFHRFK GKSVLHPMGW DAFGLPAENA 100
    AIERGISPSV WTKQNISHMR SQLKLLGLSV DWDREFATCD ENYYIWTQYL 150
    FLELYKAGLV YQKESEVNWD PVDNTVLANE QVDSEGKSWR SGAVVEKKLL 200
    KQWFLRITNY ADELLKDLEK LDNWPERVKI MQDNWIGKSI GTNINFNLNT 250
    NPEEKITVFT TRPDTLFGVT YLAISVNHSL IKYISDQETI QDIENLKQYL 300
    KNNKNNELEK IGIKTSLIAI NPINSEPIPI WVASYVLDEY GTGAVMGVPA 350
    HDQRDFEFAK KNNIDIKQVI INDKSEKTNE LDKAYVENGY LMNSDQYNFM 400
    ENTIAKLKIS EEGVDNGWAE NKIQYRLRDW LISRQRYWGC PIPIVNCKKC 450
    GSVPLKQSEL PVALPKDIDI SANKINALGD NNHWINTTCP KCGIAAKKET 500
    DTMDTFMCSS WYFLRYPSSK CSNKPFEKIE INKWLPVDQY VGGVEHAILH 550
    LLYARFFTKA LRDNELFEID EPFKKLLTQG MVQAAAYKNN KTGKYVSPSD 600
    INDLSNPTDP IDNTKLEVLF EKMSKSKYNG IDPESVIKKY GADTARMFIL 650
    FKAPPEKDLE WGDTDVEGQF RFLNRIWKLY INCAKDINSK SNSYPDREKS 700
    LIKSMNIAIK EISNDILNNQ FNTAISELMK FYNSLANSIN DVNNTLKIEA 750
    LKTFCILLAP FAPHIAEEIW HLIGFKKSVH LEYWPSFNAE ALKEDSYELV 800
    IQVNGKVRDK VKINNDMSED QIKELTLKRP NILKWTQDKE IRKIIIVKGK 850
    IINIVV 856
    Length:856
    Mass (Da):98,952
    Last modified:November 13, 2007 - v1
    Checksum:iCB977FD2125F5D68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000825 Genomic DNA. Translation: ABV50618.1.
    RefSeqiWP_012007705.1. NC_009840.1.
    YP_001484204.1. NC_009840.1.

    Genome annotation databases

    EnsemblBacteriaiABV50618; ABV50618; P9215_10031.
    GeneIDi5615845.
    KEGGipmh:P9215_10031.
    PATRICi22991502. VBIProMar119824_1023.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000825 Genomic DNA. Translation: ABV50618.1 .
    RefSeqi WP_012007705.1. NC_009840.1.
    YP_001484204.1. NC_009840.1.

    3D structure databases

    ProteinModelPortali A8G4T7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93060.P9215_10031.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV50618 ; ABV50618 ; P9215_10031 .
    GeneIDi 5615845.
    KEGGi pmh:P9215_10031.
    PATRICi 22991502. VBIProMar119824_1023.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VHRQSWP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PMAR93060:GI08-1034-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9215.

    Entry informationi

    Entry nameiSYL_PROM2
    AccessioniPrimary (citable) accession number: A8G4T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3