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A8G4P2

- ISPE_PROM2

UniProt

A8G4P2 - ISPE_PROM2

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Protein
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Gene
ispE, P9215_09581
Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity.UniRule annotation

Catalytic activityi

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei16 – 161 By similarity
Active sitei142 – 1421 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 11011ATP Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR93060:GI08-987-MONOMER.
UniPathwayiUPA00056; UER00094.

Names & Taxonomyi

Protein namesi
Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC:2.7.1.148)
Short name:
CMK
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene namesi
Name:ispE
Ordered Locus Names:P9215_09581
OrganismiProchlorococcus marinus (strain MIT 9215)
Taxonomic identifieri93060 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3113114-diphosphocytidyl-2-C-methyl-D-erythritol kinaseUniRule annotation
PRO_1000057424Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93060.P9215_09581.

Structurei

3D structure databases

ProteinModelPortaliA8G4P2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1947.
HOGENOMiHOG000019600.
KOiK00919.
OMAiELAMIMQ.
OrthoDBiEOG62VNQ2.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00061. IspE.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF010376. IspE. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00154. ispE. 1 hit.

Sequencei

Sequence statusi: Complete.

A8G4P2-1 [UniParc]FASTAAdd to Basket

« Hide

MQDLAGKKII IKSPAKINLH LEVIGKREDG FHELAMIMQN IDLFDYLEFQ    50
INNEGLIKLE SDCTDLSLSS DNLIVKSANL LRKKLNIDCG ANIFLRKNIP 100
IGAGLAGGSS NAAATLIGLN KLWDLNVDQK TLFSLASTLG SDIPFFINGG 150
IQLCFGRGEI LEKLDSNFDY GVILLKNPNV SVSTAETYSK YSNRFCYQYL 200
TNGEMIENIR NNLRDNGLNN LNFDKQHLTI KNDLQLVVEN DNDSVKEALY 250
LLSKLENCLT FSMSGSGPTC FAIFKDIETA KKELNANSKL FEDKGYDAWV 300
CTFFEKGITF I 311
Length:311
Mass (Da):34,714
Last modified:November 13, 2007 - v1
Checksum:iC7A64D7DB4483A35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV50573.1.
RefSeqiYP_001484159.1. NC_009840.1.

Genome annotation databases

EnsemblBacteriaiABV50573; ABV50573; P9215_09581.
GeneIDi5616081.
KEGGipmh:P9215_09581.
PATRICi22991412. VBIProMar119824_0979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV50573.1 .
RefSeqi YP_001484159.1. NC_009840.1.

3D structure databases

ProteinModelPortali A8G4P2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 93060.P9215_09581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV50573 ; ABV50573 ; P9215_09581 .
GeneIDi 5616081.
KEGGi pmh:P9215_09581.
PATRICi 22991412. VBIProMar119824_0979.

Phylogenomic databases

eggNOGi COG1947.
HOGENOMi HOG000019600.
KOi K00919.
OMAi ELAMIMQ.
OrthoDBi EOG62VNQ2.

Enzyme and pathway databases

UniPathwayi UPA00056 ; UER00094 .
BioCyci PMAR93060:GI08-987-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00061. IspE.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR20861:SF2. PTHR20861:SF2. 1 hit.
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF010376. IspE. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00154. ispE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9215.

Entry informationi

Entry nameiISPE_PROM2
AccessioniPrimary (citable) accession number: A8G4P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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