ID   A8G4A1_PROM2            Unreviewed;       546 AA.
AC   A8G4A1;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE            EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN   OrderedLocusNames=P9215_08171 {ECO:0000313|EMBL:ABV50432.1};
OS   Prochlorococcus marinus (strain MIT 9215).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC   Prochlorococcaceae; Prochlorococcus.
OX   NCBI_TaxID=93060 {ECO:0000313|EMBL:ABV50432.1, ECO:0000313|Proteomes:UP000002014};
RN   [1] {ECO:0000313|EMBL:ABV50432.1, ECO:0000313|Proteomes:UP000002014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9215 {ECO:0000313|EMBL:ABV50432.1,
RC   ECO:0000313|Proteomes:UP000002014};
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
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DR   EMBL; CP000825; ABV50432.1; -; Genomic_DNA.
DR   RefSeq; WP_012007542.1; NC_009840.1.
DR   AlphaFoldDB; A8G4A1; -.
DR   STRING; 93060.P9215_08171; -.
DR   KEGG; pmh:P9215_08171; -.
DR   eggNOG; COG1793; Bacteria.
DR   HOGENOM; CLU_005138_6_2_3; -.
DR   OrthoDB; 9767858at2; -.
DR   Proteomes; UP000002014; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07972; OBF_DNA_ligase_Arch_LigB; 1.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR026333; ATP_dep_DNA_lig_pp_1105_fam.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   NCBIfam; TIGR04120; DNA_lig_bact; 1.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   PANTHER; PTHR45674:SF13; DNA LIGASE-RELATED; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ABV50432.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          313..450
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   546 AA;  63984 MW;  85F014F665200D0D CRC64;
     MSLKKFSELF GDLDSINSTN NKIELLKSFF LSNEPIDNSW AIYLLTGKSN KRFISGRSLK
     NIFSQIYEYP QWLIDTCYLK VGDSAEVITL LLKNKTSSRN KKLSNISLNE LLSKTIPKLS
     KLNEEEKNLE IKNLWETLPE DNHLIFNKIL TGTFRVGVSI GLITKSISKL INIDEEIISH
     RLMGNFKPSI DSYEFLINKN INLEELNSKP FPFLLANTFE DKIFKNSINN FQFEWKYDGI
     RIQLIKRSGN VSLWTRGQEL VNESFPELVE KMSHIKDNFV LDGELLVWNF KEKIPFDFHF
     LQKRINRKSP TRSIQIKYPI IFIAYDLLEI NGRDIREIKL KNRRIELEKY FSKWRNKAEN
     NITDIFTICD LIYPKDWPDA LTFKEKSREN NTEGLIIKNK MSSYTSGRKK GIWWKYKVDP
     MQLDAVLIYA KGGSGRRAGL YTDYSFALWK GQELIKFASA YSGLTNIEIK ELDKWIRKNT
     IEKFGPVRSL KPEMVFEISF EKIQISKRHK SGIAVRFPRI TKWRKDKKIN DADSLENAYK
     LMKKIS
//