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A8G3Y5

- A8G3Y5_PROM2

UniProt

A8G3Y5 - A8G3Y5_PROM2

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Protein

Acetyl-coenzyme A synthetase

Gene
acs, acsA, P9215_07011
Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA By similarity.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei322 – 3221Coenzyme A By similarityUniRule annotation
Binding sitei398 – 3981Substrate; via nitrogen amide By similarityUniRule annotation
Binding sitei516 – 5161Substrate By similarityUniRule annotation
Binding sitei531 – 5311Substrate By similarityUniRule annotation
Active sitei533 – 5331 By similarityUniRule annotation
Binding sitei539 – 5391Coenzyme A By similarityUniRule annotation
Binding sitei542 – 5421Substrate By similarityUniRule annotation
Metal bindingi553 – 5531Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi558 – 5581Magnesium; via carbonyl oxygen By similarityUniRule annotation
Binding sitei600 – 6001Coenzyme A By similarityUniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR93060:GI08-725-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:acsImported
Synonyms:acsAUniRule annotation
Ordered Locus Names:P9215_07011Imported
OrganismiProchlorococcus marinus (strain MIT 9215)Imported
Taxonomic identifieri93060 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002014: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei625 – 6251N6-acetyllysine By similarityUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi93060.P9215_07011.

Structurei

3D structure databases

ProteinModelPortaliA8G3Y5.
SMRiA8G3Y5. Positions 21-658.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni422 – 4276Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiAGCAVFV.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8G3Y5-1 [UniParc]FASTAAdd to Basket

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MSLDKKNSIN NILEEKRIFP PSKKFAENSN ISTQEELLSL KKQASDNPIQ    50
FWESFAKSEL DWFKPFQTVL DKENAPFFKW FKEGKLNITY NCLDRHIKRG 100
LGGKTALIWE GEPGDSKKYT YEELLKEVCK AANALKAIGV KKGDLVCIYM 150
PMIPEAMFAM LACARIGAPH SVVFGGFSSE ALKDRLIDGN ARFVITADGG 200
FRKDKVIELK KAVDAAIESG ADKVVEKVVV VQRSQKNISM VDDRDFWWHE 250
LLKDQKDHCE PEIMNSEDRL FILYTSGSTG KPKGVVHTTG GYNLWTHLTF 300
KWIFDLKDDD IYWCTADVGW ITGHSYIVYG PLSNGATTLM YEGVPRPSNL 350
GAFWEIVQKY KVSIFYTAPT AIRAFMKSGR EIPDKYNLES LRLLGTVGEP 400
INPEAWMWYK DVIGKDKCPI VDTWWQTETG GVMISPLPGV VATKPGSATF 450
PLPGIEVEIV DKNGDKVKEN EGGYLIIKKP WPGMMRTIHG NSERYLESYW 500
EYISFKGEQN VYFAGDGARI DEDGYIWIMG RVDDVISVSG HRLGTMEIES 550
ALVSHKSVAE SAVVGKKDDL KGEVIVAFVS LEKDVNGSSE LVENLKKHVV 600
NEIGIIAKPE KIIISDFLPK TRSGKIMRRI LRSLAAGEKI SGDISTLEDS 650
SVLEKLKELS 660
Length:660
Mass (Da):74,061
Last modified:November 13, 2007 - v1
Checksum:i00F0F96C4E7DDEEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV50316.1.
RefSeqiYP_001483902.1. NC_009840.1.

Genome annotation databases

EnsemblBacteriaiABV50316; ABV50316; P9215_07011.
GeneIDi5615997.
KEGGipmh:P9215_07011.
PATRICi22990866. VBIProMar119824_0708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV50316.1 .
RefSeqi YP_001483902.1. NC_009840.1.

3D structure databases

ProteinModelPortali A8G3Y5.
SMRi A8G3Y5. Positions 21-658.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93060.P9215_07011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV50316 ; ABV50316 ; P9215_07011 .
GeneIDi 5615997.
KEGGi pmh:P9215_07011.
PATRICi 22990866. VBIProMar119824_0708.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi AGCAVFV.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci PMAR93060:GI08-725-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9215Imported.

Entry informationi

Entry nameiA8G3Y5_PROM2
AccessioniPrimary (citable) accession number: A8G3Y5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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