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A8G3Y5

- A8G3Y5_PROM2

UniProt

A8G3Y5 - A8G3Y5_PROM2

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Protein

Acetyl-coenzyme A synthetase

Gene

acs

Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Note: Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei322 – 3221Coenzyme AUniRule annotation
Binding sitei516 – 5161ATPUniRule annotation
Binding sitei531 – 5311ATPUniRule annotation
Binding sitei539 – 5391Coenzyme A; via carbonyl oxygenUniRule annotation
Binding sitei542 – 5421ATPUniRule annotation
Metal bindingi553 – 5531Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi555 – 5551Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi558 – 5581Magnesium; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi398 – 4003ATPUniRule annotation
Nucleotide bindingi422 – 4276ATPUniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR93060:GI08-725-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligaseUniRule annotation
Acyl-activating enzymeUniRule annotation
Gene namesi
Name:acsImported
Synonyms:acsAUniRule annotation
Ordered Locus Names:P9215_07011Imported
OrganismiProchlorococcus marinus (strain MIT 9215)Imported
Taxonomic identifieri93060 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002014: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei625 – 6251N6-acetyllysineUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi93060.P9215_07011.

Structurei

3D structure databases

ProteinModelPortaliA8G3Y5.
SMRiA8G3Y5. Positions 21-658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni202 – 2054Coenzyme A bindingUniRule annotation

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiAGCAVFV.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8G3Y5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLDKKNSIN NILEEKRIFP PSKKFAENSN ISTQEELLSL KKQASDNPIQ
60 70 80 90 100
FWESFAKSEL DWFKPFQTVL DKENAPFFKW FKEGKLNITY NCLDRHIKRG
110 120 130 140 150
LGGKTALIWE GEPGDSKKYT YEELLKEVCK AANALKAIGV KKGDLVCIYM
160 170 180 190 200
PMIPEAMFAM LACARIGAPH SVVFGGFSSE ALKDRLIDGN ARFVITADGG
210 220 230 240 250
FRKDKVIELK KAVDAAIESG ADKVVEKVVV VQRSQKNISM VDDRDFWWHE
260 270 280 290 300
LLKDQKDHCE PEIMNSEDRL FILYTSGSTG KPKGVVHTTG GYNLWTHLTF
310 320 330 340 350
KWIFDLKDDD IYWCTADVGW ITGHSYIVYG PLSNGATTLM YEGVPRPSNL
360 370 380 390 400
GAFWEIVQKY KVSIFYTAPT AIRAFMKSGR EIPDKYNLES LRLLGTVGEP
410 420 430 440 450
INPEAWMWYK DVIGKDKCPI VDTWWQTETG GVMISPLPGV VATKPGSATF
460 470 480 490 500
PLPGIEVEIV DKNGDKVKEN EGGYLIIKKP WPGMMRTIHG NSERYLESYW
510 520 530 540 550
EYISFKGEQN VYFAGDGARI DEDGYIWIMG RVDDVISVSG HRLGTMEIES
560 570 580 590 600
ALVSHKSVAE SAVVGKKDDL KGEVIVAFVS LEKDVNGSSE LVENLKKHVV
610 620 630 640 650
NEIGIIAKPE KIIISDFLPK TRSGKIMRRI LRSLAAGEKI SGDISTLEDS
660
SVLEKLKELS
Length:660
Mass (Da):74,061
Last modified:November 13, 2007 - v1
Checksum:i00F0F96C4E7DDEEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000825 Genomic DNA. Translation: ABV50316.1.
RefSeqiYP_001483902.1. NC_009840.1.

Genome annotation databases

EnsemblBacteriaiABV50316; ABV50316; P9215_07011.
GeneIDi5615997.
KEGGipmh:P9215_07011.
PATRICi22990866. VBIProMar119824_0708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000825 Genomic DNA. Translation: ABV50316.1 .
RefSeqi YP_001483902.1. NC_009840.1.

3D structure databases

ProteinModelPortali A8G3Y5.
SMRi A8G3Y5. Positions 21-658.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93060.P9215_07011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV50316 ; ABV50316 ; P9215_07011 .
GeneIDi 5615997.
KEGGi pmh:P9215_07011.
PATRICi 22990866. VBIProMar119824_0708.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi AGCAVFV.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci PMAR93060:GI08-725-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9215Imported.

Entry informationi

Entry nameiA8G3Y5_PROM2
AccessioniPrimary (citable) accession number: A8G3Y5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3