A8G3X9 (AROA_PROM2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	P9215_06951

Organism

Prochlorococcus marinus (strain MIT 9215) [Complete proteome] [HAMAP]

Taxonomic identifier

93060 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000058606

Sequences

	Sequence		Length	Mass (Da)
	A8G3X9 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 64F63FD0D0CA1A34	FASTA	436	46,362
	10 20 30 40 50 60 MNNIRTIKGG TKLKGKIKVP GDKSISHRAL IIGSIAKGNT TIEGFLHSED PLSTADCLRK 70 80 90 100 110 120 LGVNIPKIIK DEPFTISGKG LDGLKEPKEI LNCGNSGTTM RLLMGLLAAQ EGKNFILTGD 130 140 150 160 170 180 ASLNERPMGR VGKPLSLMGG KISGREFGNK APISINGEKL KGCVIGTPVA SAQVKSAILL 190 200 210 220 230 240 AGLNASGTTS VIEPASSRDH TERMLKAFGA DISIRGELGR NIVITSGGNL IGQRILIPGD 250 260 270 280 290 300 ISSASFWMIA ASIVPNSEVL IQNVGLNPTR TGILNVMDSM GCNYEILDKS TIAGEPIGSI 310 320 330 340 350 360 KVKTSNNLRS FTVEGDILPK LIDEIPILTV AACFCSGVSE IKDAQELRVK ETDRLKVMAR 370 380 390 400 410 420 QLQKFGAKIT EKEDGLIING QSKFHSAEVD SETDHRVAMS LAIASLLAKG TSKIMRAGAA 430 SVSYPTFWEE LDKLTN

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9215.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000825 Genomic DNA. Translation: ABV50310.1.
RefSeq	YP_001483896.1. NC_009840.1.
3D structure databases
ProteinModelPortal	A8G3X9.
ModBase	Search...
Protein-protein interaction databases
STRING	A8G3X9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5615586.
GenomeReviews	Gene locus P9215_06951 in contig CP000825_GR.
KEGG	pmh:P9215_06951.
PATRIC	22990854. VBIProMar119824_0702.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	LECANIS.
PhylomeDB	A8G3X9.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	PMAR93060:P9215_06951-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_PROM2

Accession

Primary (citable) accession number: A8G3X9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program