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A8G3V6

- PROA_PROM2

UniProt

A8G3V6 - PROA_PROM2

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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciPMAR93060:GI08-696-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:P9215_06721
OrganismiProchlorococcus marinus (strain MIT 9215)
Taxonomic identifieri93060 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002014: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Gamma-glutamyl phosphate reductasePRO_1000060843Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93060.P9215_06721.

Structurei

3D structure databases

ProteinModelPortaliA8G3V6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiQIQIKRE.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8G3V6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANIFEVPQP DNDLLEKAEK VRLASIKISQ TENKNRIKAL NFMADYLEKN
60 70 80 90 100
SKEILEANNA DYSSAEKKGI SKALLSRLKL SRAKLNAGIE GVRKVGDLAD
110 120 130 140 150
PVNQVQIKKE LSKGLILERK TVPIGVLGII FESRPDAVMQ ISSLAIRSGN
160 170 180 190 200
GVMLKGGSEA NLTNTSIVKA LQEGLNESGL DRNAICLLTS RKDSMAMLNL
210 220 230 240 250
EKYINLIIPR GSNELVKFIQ ENTRIPVLGH ADGICHLFID IEANLEMALS
260 270 280 290 300
VALDSKIQYP AACNAIETLL VHKDIAPAFL EKAIPLFNSN DVKLIGDNRS
310 320 330 340 350
VELGLKYEAS LQDWKTEYLD LILSIKIVNN VEEAITHIQK YSSKHTDGII
360 370 380 390 400
TENSNTANKF MNVVDSSGVF HNCSTRFADG FRYGFGAEVG ISTQTLPPRG
410 420 430
PVGLEGLVTY KYFLKGGGHI VDDFSSGKAI YTHKDL
Length:436
Mass (Da):47,862
Last modified:November 13, 2007 - v1
Checksum:i29680531FC3AAFBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000825 Genomic DNA. Translation: ABV50287.1.
RefSeqiWP_012007407.1. NC_009840.1.
YP_001483873.1. NC_009840.1.

Genome annotation databases

EnsemblBacteriaiABV50287; ABV50287; P9215_06721.
GeneIDi5614732.
KEGGipmh:P9215_06721.
PATRICi22990808. VBIProMar119824_0679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000825 Genomic DNA. Translation: ABV50287.1 .
RefSeqi WP_012007407.1. NC_009840.1.
YP_001483873.1. NC_009840.1.

3D structure databases

ProteinModelPortali A8G3V6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93060.P9215_06721.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV50287 ; ABV50287 ; P9215_06721 .
GeneIDi 5614732.
KEGGi pmh:P9215_06721.
PATRICi 22990808. VBIProMar119824_0679.

Phylogenomic databases

eggNOGi COG0014.
HOGENOMi HOG000246356.
KOi K00147.
OMAi QIQIKRE.
OrthoDBi EOG6FFSCX.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00360 .
BioCyci PMAR93060:GI08-696-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPi MF_00412. ProA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000151. GPR. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00407. proA. 1 hit.
PROSITEi PS01223. PROA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9215.

Entry informationi

Entry nameiPROA_PROM2
AccessioniPrimary (citable) accession number: A8G3V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3