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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciPMAR93060:G1GA0-663-MONOMER
UniPathwayiUPA00098; UER00360

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:P9215_06721
OrganismiProchlorococcus marinus (strain MIT 9215)
Taxonomic identifieri93060 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000608431 – 436Gamma-glutamyl phosphate reductaseAdd BLAST436

Proteomic databases

PRIDEiA8G3V6

Interactioni

Protein-protein interaction databases

STRINGi93060.P9215_06721

Structurei

3D structure databases

ProteinModelPortaliA8G3V6
SMRiA8G3V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2S Bacteria
COG0014 LUCA
HOGENOMiHOG000246356
KOiK00147
OMAiHGSHHTD
OrthoDBiPOG091H00OT

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit

Sequencei

Sequence statusi: Complete.

A8G3V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANIFEVPQP DNDLLEKAEK VRLASIKISQ TENKNRIKAL NFMADYLEKN
60 70 80 90 100
SKEILEANNA DYSSAEKKGI SKALLSRLKL SRAKLNAGIE GVRKVGDLAD
110 120 130 140 150
PVNQVQIKKE LSKGLILERK TVPIGVLGII FESRPDAVMQ ISSLAIRSGN
160 170 180 190 200
GVMLKGGSEA NLTNTSIVKA LQEGLNESGL DRNAICLLTS RKDSMAMLNL
210 220 230 240 250
EKYINLIIPR GSNELVKFIQ ENTRIPVLGH ADGICHLFID IEANLEMALS
260 270 280 290 300
VALDSKIQYP AACNAIETLL VHKDIAPAFL EKAIPLFNSN DVKLIGDNRS
310 320 330 340 350
VELGLKYEAS LQDWKTEYLD LILSIKIVNN VEEAITHIQK YSSKHTDGII
360 370 380 390 400
TENSNTANKF MNVVDSSGVF HNCSTRFADG FRYGFGAEVG ISTQTLPPRG
410 420 430
PVGLEGLVTY KYFLKGGGHI VDDFSSGKAI YTHKDL
Length:436
Mass (Da):47,862
Last modified:November 13, 2007 - v1
Checksum:i29680531FC3AAFBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000825 Genomic DNA Translation: ABV50287.1
RefSeqiWP_012007407.1, NC_009840.1

Genome annotation databases

EnsemblBacteriaiABV50287; ABV50287; P9215_06721
KEGGipmh:P9215_06721

Similar proteinsi

Entry informationi

Entry nameiPROA_PROM2
AccessioniPrimary (citable) accession number: A8G3V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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