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A8G3T4 (A8G3T4_PROM2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase RuleBase RU003440
EC=3.5.2.3 RuleBase RU003440
Gene names
Name:pyrC EMBL ABV50265.1
Ordered Locus Names:P9215_06501
OrganismProchlorococcus marinus (strain MIT 9215) [Complete proteome] [HAMAP]
Taxonomic identifier93060 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003440 SAAS SAAS004721

Cofactor

Binds 2 zinc ions per subunit By similarity. RuleBase RU003440 SAAS SAAS004721

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003440 SAAS SAAS004721

Subunit structure

Homodimer By similarity. SAAS SAAS004721

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily. RuleBase RU003440

Sequences

Sequence LengthMass (Da)Tools
A8G3T4 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 78EE2C5D655E4622

FASTA34939,770
        10         20         30         40         50         60 
MKTLNIIKPD DWHLHLREGL VLKNIIQFTS EYFGRAIVMP NTKRPITSIN SAISYRKSIF 

        70         80         90        100        110        120 
EALPESSKFE PLMTIYLTDE TDKGELINGF KNNVFFAAKL YPANATTNSS HGVRKIENLY 

       130        140        150        160        170        180 
KIFELMQDSG MPLLIHGEVT DSKVDVFDRE EVFIDKELSQ ITKRFPKLKI VLEHITTSYA 

       190        200        210        220        230        240 
VDFVQENNIG ATITPHHLHI NRNAMFFGGL NSDFYCLPVA KRENNRLALR KAATSGKKCF 

       250        260        270        280        290        300 
FLGTDSAPHL RKWKAFCGCA GIFNSPVAIE SYLTVFEEED ALDNFEKFAS LNGPNFYNVP 

       310        320        330        340 
PNKEKLKLVS RPNKIKEYID VIEEKNIIGQ IKPFHAGETL QWQVEGIVN

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References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000825 Genomic DNA. Translation: ABV50265.1.
RefSeqYP_001483851.1. NC_009840.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA8G3T4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5615231.
GenomeReviewsGene locus P9215_06501 in contig CP000825_GR.
KEGGpmh:P9215_06501.
PATRIC22990758. VBIProMar119824_0655.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0418.
HOGENOMHBG628648.
OMACLPVAKR.
PhylomeDBA8G3T4.
ProtClustDBPRK05451.

Enzyme and pathway databases

BioCycPMAR93060:P9215_06501-MONOMER.

Family and domain databases

InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. PyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8G3T4_PROM2
AccessionPrimary (citable) accession number: A8G3T4
Entry history
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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