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A8G3P0 (HEMH_PROM2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:P9215_06061
OrganismProchlorococcus marinus (strain MIT 9215) [Complete proteome] [HAMAP]
Taxonomic identifier93060 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Ferrochelatase HAMAP MF_00323
PRO_1000059486

Sites

Metal binding1961Iron By similarity
Metal binding2811Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A8G3P0 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 50FBB202BEFA54C2

FASTA39144,284
        10         20         30         40         50         60 
MDKIGVLLMN LGGPERINDV GPFLYNLFSD PEIIRIPFPV FQKPLAWLIS TLRSTTSQQA 

        70         80         90        100        110        120 
YLSIGGGSPI RRITEQQARE LQSKLRDKGL NATTYIAMRY WHPFTESAIA DMKADGIDQV 

       130        140        150        160        170        180 
VVIPLYPHFS ISTSGSSFRE LKKLRDSDDE FKKVPMRCVR SWYSQSDYLK SMVELISEQI 

       190        200        210        220        230        240 
SLCESPSKAH IFFTAHGVPK SYVEEAGDPY KQQIEDCSLL IINELEKCLG HSNPHTLSYQ 

       250        260        270        280        290        300 
SRVGPVEWLK PYTEEVLADL GRSNVNDLIV VPISFVGEHI ETLQEIDIEY KEIAEQAGIK 

       310        320        330        340        350        360 
NFRRVKALNT HPTFIEGLSD LVISCLEGPL VNLEEASQLP EKVKLYPQEK WQWGWNNSSE 

       370        380        390 
VWNGRVAMII FLVLFIELIS GSGPLHKLGI L

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9215.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000825 Genomic DNA. Translation: ABV50221.1.
RefSeqYP_001483807.1. NC_009840.1.

3D structure databases

ProteinModelPortalA8G3P0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8G3P0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5615393.
GenomeReviewsGene locus P9215_06061 in contig CP000825_GR.
KEGGpmh:P9215_06061.
PATRIC22990670. VBIProMar119824_0611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBA8G3P0.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycPMAR93060:P9215_06061-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_PROM2
AccessionPrimary (citable) accession number: A8G3P0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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