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A8G2S6

- PUR9_PROM2

UniProt

A8G2S6 - PUR9_PROM2

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, P9215_02901
Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPMAR93060:GI08-296-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:P9215_02901
OrganismiProchlorococcus marinus (strain MIT 9215)
Taxonomic identifieri93060 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000057905Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93060.P9215_02901.

Structurei

3D structure databases

ProteinModelPortaliA8G2S6.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCNLKGIS.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A8G2S6-1 [UniParc]FASTAAdd to Basket

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MSPLALVSVS DKKNIIQFCK ELIENFNYKI LSSGGTAKHL IEAKIPVIKV    50
ADFTNSQEIL GGRVKTLHPK IHGGILAKRT DEEHQIDIKA NDLELIDLVV 100
VNLYPFKKTI DQGAKWEDAI ENIDIGGPSM IRSAAKNHKY VSVLVDPSQY 150
QNFLEESKKG ELKESYKAKL ALEAFQHTAD YDTAISNWIS KERGFQSSKH 200
IKSYPLIKSL RYGENPHQKA FWYGLSNIGW NSAKQLQGKD LSYNNLLDLE 250
SALTTVLEFG YAEKDELTTD TFASIILKHN NPCGASVSNS ASQAFLNALE 300
CDSVSAFGGI VAFNSNVDSE TAIQLKDIFL ECVVAPSFDE KALEILKVKK 350
NLRILKLSKD QLPKNNQTST KSIMGGLLVQ DTDDNKEKSE GWISVTNKNP 400
SNQMNLDLNF AWKICKHVKS NAIVIAKDQK TIGIGAGQMN RVGAAKIALK 450
AAGKLCSGAV LASDGFFPFA DTVELANEYG IKAIIQPGGS LRDQESIDMC 500
NAKGIAMIFT QKRHFLH 517
Length:517
Mass (Da):57,002
Last modified:November 13, 2007 - v1
Checksum:i443E3A247CB5D12B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV49907.1.
RefSeqiWP_012007066.1. NC_009840.1.
YP_001483493.1. NC_009840.1.

Genome annotation databases

EnsemblBacteriaiABV49907; ABV49907; P9215_02901.
GeneIDi5615960.
KEGGipmh:P9215_02901.
PATRICi22989992. VBIProMar119824_0286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV49907.1 .
RefSeqi WP_012007066.1. NC_009840.1.
YP_001483493.1. NC_009840.1.

3D structure databases

ProteinModelPortali A8G2S6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93060.P9215_02901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV49907 ; ABV49907 ; P9215_02901 .
GeneIDi 5615960.
KEGGi pmh:P9215_02901.
PATRICi 22989992. VBIProMar119824_0286.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CNLKGIS.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PMAR93060:GI08-296-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9215.

Entry informationi

Entry nameiPUR9_PROM2
AccessioniPrimary (citable) accession number: A8G2S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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