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A8G243

- SPEA_PROM2

UniProt

A8G243 - SPEA_PROM2

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Protein
Biosynthetic arginine decarboxylase
Gene
speA, P9215_00551
Organism
Prochlorococcus marinus (strain MIT 9215)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR93060:GI08-57-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:P9215_00551
OrganismiProchlorococcus marinus (strain MIT 9215)
Taxonomic identifieri93060 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Biosynthetic arginine decarboxylaseUniRule annotation
PRO_1000068493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi93060.P9215_00551.

Structurei

3D structure databases

ProteinModelPortaliA8G243.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni291 – 30111Substrate-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiANIRDIH.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8G243-1 [UniParc]FASTAAdd to Basket

« Hide

MTNFEPKKLK KNWTIEDSIS TYEIDKWGDK YFSINSKGNI SVTKDINSEK    50
KIDLFKLVRE LKSREINTPL IIRFNDILKD RINALHDAFL KAIKTYKYKN 100
IYQGVFPVKC NQQKNVLEKI IEFGSPWNFG LEVGSKSELL IGLALLENQN 150
SLLICNGYKD KKYIEIATLA RKLGKNPIIV IEQKDEVNRI IEAVQDLNAS 200
PLIGIRAKLS SKSSGRWSKS VGDNSKFGLS IPEIMSTIKE LKEANLINEM 250
RLLHFHIGSQ ISDIAVIKDA LQEASQIYVE LFKLGAPMKY IDVGGGLGID 300
FDGTKTSSNT STNYSLQNYA NDVIATIKDS CELNNIEHPT IISESGRAII 350
SHCSVLIFNV LGTSHVSSKL KIYDDKKQSL IISNLIETFY ELKKLKNKKI 400
NLSQIIELWN DAKKFKEDCL VAFRLGFLSL AERAYAEELT WACAKEIANN 450
LNNDEINHPD LFEITETLAS TYYANLSIFK SIPDCWAINQ IFPIMPIHRH 500
LEEPFCKGNF ADLTCDSDGK LNSFINNGKI KSLLNLHEPE QDKDYLIGIF 550
MTGAYQEALG NLHNLFGNTN VVHIDINQND SYKVKNIIKE DSKSEILQLL 600
DYSSASLVES IRINTEAAID QKKLTIEEAR KLIDQIEISL RKSSYLSE 648
Length:648
Mass (Da):73,405
Last modified:November 13, 2007 - v1
Checksum:i3472447352E0C4E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV49674.1.
RefSeqiWP_012006859.1. NC_009840.1.
YP_001483260.1. NC_009840.1.

Genome annotation databases

EnsemblBacteriaiABV49674; ABV49674; P9215_00551.
GeneIDi5615874.
KEGGipmh:P9215_00551.
PATRICi22989523. VBIProMar119824_0056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000825 Genomic DNA. Translation: ABV49674.1 .
RefSeqi WP_012006859.1. NC_009840.1.
YP_001483260.1. NC_009840.1.

3D structure databases

ProteinModelPortali A8G243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93060.P9215_00551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV49674 ; ABV49674 ; P9215_00551 .
GeneIDi 5615874.
KEGGi pmh:P9215_00551.
PATRICi 22989523. VBIProMar119824_0056.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi ANIRDIH.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci PMAR93060:GI08-57-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9215.

Entry informationi

Entry nameiSPEA_PROM2
AccessioniPrimary (citable) accession number: A8G243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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