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A8G208 (A8G208_PROM2) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP-Rule MF_00037
EC=1.1.1.158 HAMAP-Rule MF_00037
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase HAMAP-Rule MF_00037
Gene names
Name:murB HAMAP-Rule MF_00037
Ordered Locus Names:P9215_00201
OrganismProchlorococcus marinus (strain MIT 9215) [Complete proteome] [HAMAP] EMBL ABV49639.1
Taxonomic identifier93060 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorales › Prochlorococcaceae › Prochlorococcus ›

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00037 SAAS SAAS003170

Catalytic activity

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH. HAMAP-Rule MF_00037 SAAS SAAS003170

Cofactor

FAD By similarity. HAMAP-Rule MF_00037 SAAS SAAS003170

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00037 SAAS SAAS003170

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00037 SAAS SAAS003170.

Sequence similarities

Belongs to the MurB family. HAMAP-Rule MF_00037

Contains 1 FAD-binding PCMH-type domain. HAMAP-Rule MF_00037 SAAS SAAS003170

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain19 – 187169FAD-binding PCMH-type By similarity HAMAP-Rule MF_00037

Sites

Active site1661 By similarity HAMAP-Rule MF_00037
Active site2171Proton donor By similarity HAMAP-Rule MF_00037
Active site2871 By similarity HAMAP-Rule MF_00037

Sequences

Sequence LengthMass (Da)Tools
A8G208 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: FFC51CDDA026C209

FASTA29732,924
        10         20         30         40         50         60 
MNKKNFSENC NLSSYTTIKV GGVAEYFAEP RNIDEFLYLI KWANLNKQRC QIIGAGSNLL 

        70         80         90        100        110        120 
INNIFIKGLV VCTKKMKSLT IEPHSGIVEA EAGVMLPTLS NSLAKNGLQG GEWAVGIPGT 

       130        140        150        160        170        180 
LGGAIYMNAG TGNLSLAKNL ISVKVINNKT LEKLEIKKKD INFKYRFSSF QKNDLTIVSA 

       190        200        210        220        230        240 
RLHFEPNGNL EQLIQKTKNN LKLKIETQPY HQPSFGSVFK NPENNYAAKL IDDLGLKGFK 

       250        260        270        280        290 
IGGAEISTMH SNFIINTSSA SSKDIYELIT VIQQKVLQNK GVFLQPEVRM IGFDYPN

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:E231-E231(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9215.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000825 Genomic DNA. Translation: ABV49639.1.
RefSeqYP_001483225.1. NC_009840.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING93060.P9215_00201.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV49639; ABV49639; P9215_00201.
GeneID5615066.
KEGGpmh:P9215_00201.
PATRIC22989453. VBIProMar119824_0021.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0812.
HOGENOMHOG000284355.
KOK00075.
OMACAGSIFR.
ProtClustDBPRK13905.

Enzyme and pathway databases

BioCycPMAR93060:GI08-63-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPMF_00037. MurB.
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERPTHR21071. PTHR21071. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. FAD-binding_2. 1 hit.
SSF56194. MurB_C. 1 hit.
TIGRFAMsTIGR00179. murB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8G208_PROM2
AccessionPrimary (citable) accession number: A8G208
Entry history
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info