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A8G1Z9 (ARLY_PROM2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:P9215_00111
OrganismProchlorococcus marinus (strain MIT 9215) [Complete proteome] [HAMAP]
Taxonomic identifier93060 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459Argininosuccinate lyase HAMAP MF_00006
PRO_1000057054

Sequences

Sequence LengthMass (Da)Tools
A8G1Z9 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 73892A93977EC59E

FASTA45952,089
        10         20         30         40         50         60 
MAKVWSKRFD NALDPFIEKF NASIGFDRKL ILEDLDCSIA HAKMLGKTQV LTSSESSQII 

        70         80         90        100        110        120 
NGLELIKVEY LEGKFSPGLP SEDIHYSIEE KLISLIGETG KKLHTGRSRN DQVGTDIRLW 

       130        140        150        160        170        180 
LRKEIDKIEI LITDLQKSFF NIAKSNIYTL IPGYTHMQRA QPLSLAHHLL AYIEMLQRDR 

       190        200        210        220        230        240 
ERFKEVRARV NISPLGAAAL AGTKIKIDRQ FTASELGFEK IYKNSIDAVS DRDFCIEFVS 

       250        260        270        280        290        300 
ASALSMSHLS KISEEIILWV TDEFSFAKLT DKCATGSSLM PQKKNPDVPE LIRGKTGRVY 

       310        320        330        340        350        360 
GHLQALLTMV KGVPLSYNKD FQEDKEPIFD TAETISSCMK AMTILINEGI EFNIKNLSDS 

       370        380        390        400        410        420 
VENDFSNATD LADYLVGKDV PFRTAYQVVG EIVKYCLKRK MLFKNLKIGE FKKFHPEFDE 

       430        440        450 
DVFSDLKPHN VVKSRNSEGG TGFVQVEKEL NHWQKKLLL

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9215.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000825 Genomic DNA. Translation: ABV49630.1.
RefSeqYP_001483216.1. NC_009840.1.

3D structure databases

ProteinModelPortalA8G1Z9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8G1Z9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5615333.
GenomeReviewsGene locus P9215_00111 in contig CP000825_GR.
KEGGpmh:P9215_00111.
PATRIC22989435. VBIProMar119824_0012.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAEDIHTVI.
PhylomeDBA8G1Z9.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycPMAR93060:P9215_00111-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_PROM2
AccessionPrimary (citable) accession number: A8G1Z9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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