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A8G1A4

- ASSY_SHESH

UniProt

A8G1A4 - ASSY_SHESH

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei96 – 961CitrullineUniRule annotation
Binding sitei101 – 1011CitrullineUniRule annotation
Binding sitei126 – 1261ATP; via amide nitrogenUniRule annotation
Binding sitei128 – 1281AspartateUniRule annotation
Binding sitei132 – 1321AspartateUniRule annotation
Binding sitei132 – 1321CitrullineUniRule annotation
Binding sitei133 – 1331AspartateUniRule annotation
Binding sitei136 – 1361CitrullineUniRule annotation
Binding sitei185 – 1851CitrullineUniRule annotation
Binding sitei194 – 1941CitrullineUniRule annotation
Binding sitei270 – 2701CitrullineUniRule annotation
Binding sitei282 – 2821CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 249ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-4413-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Ssed_4273
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Argininosuccinate synthasePRO_1000073832Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi425104.Ssed_4273.

Structurei

3D structure databases

ProteinModelPortaliA8G1A4.
SMRiA8G1A4. Positions 12-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPWNEPTK.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8G1A4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNETKKTGV KKVVLAYSGG LDTSAIIPWL KETYDNCEII AFCADVGQGD
60 70 80 90 100
AELEGLHEKA ISSGASECYI VDLKEELVAD YIYPTIATGA IYEGTYLLGT
110 120 130 140 150
SMARPIIAKA QVEVARKVGA DAVCHGCTGK GNDQVRFEGC FAALAPDLKV
160 170 180 190 200
IAPWREWEMV SREDLLDYLA ERNIETTSSV TKIYSRDANA WHISHEGGEL
210 220 230 240 250
EDPWNEPTKG VWTMTVAPED APNEPEYVSL ELEQGKITKV NGASLSPYGA
260 270 280 290 300
LTVLNEIAGA HGVGRIDITE NRLVGMKSRG CYETPGGTVM FAALRAIEEL
310 320 330 340 350
VLDKSSREWR EQIGAQMAHL VYDGRWFTPL CESLLAASIP LANLVSGEVV
360 370 380 390 400
IKLYKGQAHA VKKRSENSLY SEEFATFGED DVYNQKDAEG FIRLYSLASR

IRALKAK
Length:407
Mass (Da):44,605
Last modified:November 13, 2007 - v1
Checksum:i5D82469233D69B2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV38877.1.
RefSeqiWP_012144606.1. NC_009831.1.
YP_001476005.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV38877; ABV38877; Ssed_4273.
GeneIDi5611913.
KEGGisse:Ssed_4273.
PATRICi23566488. VBISheSed62411_4539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV38877.1 .
RefSeqi WP_012144606.1. NC_009831.1.
YP_001476005.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8G1A4.
SMRi A8G1A4. Positions 12-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_4273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV38877 ; ABV38877 ; Ssed_4273 .
GeneIDi 5611913.
KEGGi sse:Ssed_4273.
PATRICi 23566488. VBISheSed62411_4539.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi PWNEPTK.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SSED425104:GH7Q-4413-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiASSY_SHESH
AccessioniPrimary (citable) accession number: A8G1A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3