ID   A8G0W3_SHESH            Unreviewed;       807 AA.
AC   A8G0W3;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE   AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE   AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN   OrderedLocusNames=Ssed_4132 {ECO:0000313|EMBL:ABV38736.1};
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104 {ECO:0000313|EMBL:ABV38736.1, ECO:0000313|Proteomes:UP000002015};
RN   [1] {ECO:0000313|EMBL:ABV38736.1, ECO:0000313|Proteomes:UP000002015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3 {ECO:0000313|EMBL:ABV38736.1,
RC   ECO:0000313|Proteomes:UP000002015};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; CP000821; ABV38736.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8G0W3; -.
DR   STRING; 425104.Ssed_4132; -.
DR   KEGG; sse:Ssed_4132; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   InterPro; IPR043519; NT_sf.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:ABV38736.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002015}.
FT   DOMAIN          7..204
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   807 AA;  92780 MW;  04AA33DB2503D4E0 CRC64;
     MINEQSQFIE NAERLNRIRL ARALAILSPL KRDLLRLIPL LFHYHRAGYP GYNGSMTPSG
     VFNYVPSESE LAACDTLDLV KPTQHRVKQA AIEGVYSMGS MASFGQNPKS DIDVWLVHDR
     LLTKEECRLL EDKSSLLTGW FAQYGLEVNI YLVHPEQFSK ASISEDESLH PIGQEHSGSA
     QHWLLLEEFY RSQICLAGKT VAWWPNAQRA DELLYLGDVS HIPASEYFGA SLWQLYKGLD
     KPHKALLKVL LLEAYATEYP DTLLVSEKVW QRTIDGDFSA ANDAYYLLYE SIEAYLEKQQ
     DLSRLEIVRR CFYLKCGIRL SEFEQAKDWR YHKLRSLVDS WNWSQSLIDT LDHCDDWHCG
     QLQWFNEQLN ELMLGSYQTL IQFASTNKLN GSFRLSELGL LTRKLHTYFS ADTQQIISLN
     RLWSDSIAEP DLTIIYSHND NEYCLYRCPP YSRNFIGQRA VYRSRSKAKL LAWAALNGVS
     TQVTTWYEFA NGSGKSEYLT TAAKRLISFF DLKERRVSKM DLCQPWRYKK LILLLNFNSD
     PTAQWQGQEI MVDYMNANIF SLGRRQQNML ASIDIISLNS WGEWHCHHYE GEVGILNALA
     FIIPGIRLAA EDISIEVISC SAKLKSQFER TVTGLVQRAV RLSLQVSSSS TLVYPLKVGK
     VQYGIFFNSK GMVFQDLKDA KAFYQQLTMK KVIELPRPDL GNEPFTKIPD VIQDFAAHGA
     IQYFLRQSKH GLDVFVLNEK NELNHYVQQG ANVDELVSQV SHHHAFEEPD TSTQRFNLPQ
     FFRLIRIDGR LRAIPFGVSV DEAEMDF
//