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A8FZR5

- COBT_SHESH

UniProt

A8FZR5 - COBT_SHESH

Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

    Catalytic activityi

    Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei311 – 3111Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP
    2. nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-KW
    2. nucleoside biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis

    Enzyme and pathway databases

    BioCyciSSED425104:GH7Q-3868-MONOMER.
    UniPathwayiUPA00061; UER00516.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
    Short name:
    NN:DBI PRTUniRule annotation
    Alternative name(s):
    N(1)-alpha-phosphoribosyltransferaseUniRule annotation
    Gene namesi
    Name:cobTUniRule annotation
    Ordered Locus Names:Ssed_3734
    OrganismiShewanella sediminis (strain HAW-EB3)
    Taxonomic identifieri425104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002015: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasePRO_1000078251Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi425104.Ssed_3734.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FZR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CobT family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2038.
    HOGENOMiHOG000263500.
    KOiK00768.
    OMAiYPQAVTG.
    OrthoDBiEOG6HF61K.

    Family and domain databases

    Gene3Di1.10.1610.10. 1 hit.
    HAMAPiMF_00230. CobT.
    InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
    IPR023195. Nict_dMeBzImd_PRibTrfase_N.
    IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
    [Graphical view]
    PfamiPF02277. DBI_PRT. 1 hit.
    [Graphical view]
    SUPFAMiSSF52733. SSF52733. 1 hit.
    TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8FZR5-1 [UniParc]FASTAAdd to Basket

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    MFNISPANHE FDDEIQSKID NKTKPLGALG ELENLAKQLA LVLGKDKPEI    50
    INPKLLVFAA DHGIASSGVS IAPSEVTTQM VMNFVAGGAA INVFCRQVGL 100
    DMEVIDCGIL QPLEGVEGVI DQRLGAGTGA IHKQAAMTLG AVKQGLEMAR 150
    TRIELHHQQG CNLIALGEMG IGNTSSAAAI MATVMGMKGV DCVGRGTGID 200
    AATLKRKQML VEQALHIHEA ELTDPYNILA CLGGFEIVQM TGAMLAAAER 250
    NMLVIVDGFI ATAAAMVAVQ INANVRDYMI FGHQSDERGH CLMMEHLQAR 300
    PLLRLGMRLG EGSGAVLALP LIRAAAGFYN EMASFSDAGI EI 342
    Length:342
    Mass (Da):36,215
    Last modified:November 13, 2007 - v1
    Checksum:i692789F995633F1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV38338.1.
    RefSeqiWP_012144068.1. NC_009831.1.
    YP_001475466.1. NC_009831.1.

    Genome annotation databases

    EnsemblBacteriaiABV38338; ABV38338; Ssed_3734.
    GeneIDi5614185.
    KEGGisse:Ssed_3734.
    PATRICi23565320. VBISheSed62411_3960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV38338.1 .
    RefSeqi WP_012144068.1. NC_009831.1.
    YP_001475466.1. NC_009831.1.

    3D structure databases

    ProteinModelPortali A8FZR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 425104.Ssed_3734.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV38338 ; ABV38338 ; Ssed_3734 .
    GeneIDi 5614185.
    KEGGi sse:Ssed_3734.
    PATRICi 23565320. VBISheSed62411_3960.

    Phylogenomic databases

    eggNOGi COG2038.
    HOGENOMi HOG000263500.
    KOi K00768.
    OMAi YPQAVTG.
    OrthoDBi EOG6HF61K.

    Enzyme and pathway databases

    UniPathwayi UPA00061 ; UER00516 .
    BioCyci SSED425104:GH7Q-3868-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1610.10. 1 hit.
    HAMAPi MF_00230. CobT.
    InterProi IPR003200. Nict_dMeBzImd_PRibTrfase-like.
    IPR023195. Nict_dMeBzImd_PRibTrfase_N.
    IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
    [Graphical view ]
    Pfami PF02277. DBI_PRT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52733. SSF52733. 1 hit.
    TIGRFAMsi TIGR03160. cobT_DBIPRT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB3.

    Entry informationi

    Entry nameiCOBT_SHESH
    AccessioniPrimary (citable) accession number: A8FZR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3