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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei311 – 3111Proton acceptorUniRule annotation

GO - Molecular functioni

  1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP
  2. nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-KW
  2. nucleoside biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-3868-MONOMER.
UniPathwayiUPA00061; UER00516.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:Ssed_3734
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasePRO_1000078251Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi425104.Ssed_3734.

Structurei

3D structure databases

ProteinModelPortaliA8FZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2038.
HOGENOMiHOG000263500.
KOiK00768.
OMAiATFGGFE.
OrthoDBiEOG6HF61K.

Family and domain databases

Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNISPANHE FDDEIQSKID NKTKPLGALG ELENLAKQLA LVLGKDKPEI
60 70 80 90 100
INPKLLVFAA DHGIASSGVS IAPSEVTTQM VMNFVAGGAA INVFCRQVGL
110 120 130 140 150
DMEVIDCGIL QPLEGVEGVI DQRLGAGTGA IHKQAAMTLG AVKQGLEMAR
160 170 180 190 200
TRIELHHQQG CNLIALGEMG IGNTSSAAAI MATVMGMKGV DCVGRGTGID
210 220 230 240 250
AATLKRKQML VEQALHIHEA ELTDPYNILA CLGGFEIVQM TGAMLAAAER
260 270 280 290 300
NMLVIVDGFI ATAAAMVAVQ INANVRDYMI FGHQSDERGH CLMMEHLQAR
310 320 330 340
PLLRLGMRLG EGSGAVLALP LIRAAAGFYN EMASFSDAGI EI
Length:342
Mass (Da):36,215
Last modified:November 13, 2007 - v1
Checksum:i692789F995633F1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV38338.1.
RefSeqiYP_001475466.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV38338; ABV38338; Ssed_3734.
GeneIDi5614185.
KEGGisse:Ssed_3734.
PATRICi23565320. VBISheSed62411_3960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV38338.1.
RefSeqiYP_001475466.1. NC_009831.1.

3D structure databases

ProteinModelPortaliA8FZR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi425104.Ssed_3734.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV38338; ABV38338; Ssed_3734.
GeneIDi5614185.
KEGGisse:Ssed_3734.
PATRICi23565320. VBISheSed62411_3960.

Phylogenomic databases

eggNOGiCOG2038.
HOGENOMiHOG000263500.
KOiK00768.
OMAiATFGGFE.
OrthoDBiEOG6HF61K.

Enzyme and pathway databases

UniPathwayiUPA00061; UER00516.
BioCyciSSED425104:GH7Q-3868-MONOMER.

Family and domain databases

Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiCOBT_SHESH
AccessioniPrimary (citable) accession number: A8FZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.