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A8FZR5

- COBT_SHESH

UniProt

A8FZR5 - COBT_SHESH

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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene
cobT, Ssed_3734
Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) By similarity.UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei311 – 3111Proton acceptor By similarity

GO - Molecular functioni

  1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP
  2. nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-KW
  2. nucleoside biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-3868-MONOMER.
UniPathwayiUPA00061; UER00516.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC:2.4.2.21)
Short name:
NN:DBI PRT
Alternative name(s):
N(1)-alpha-phosphoribosyltransferase
Gene namesi
Name:cobT
Ordered Locus Names:Ssed_3734
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotationPRO_1000078251Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi425104.Ssed_3734.

Structurei

3D structure databases

ProteinModelPortaliA8FZR5.

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.

Phylogenomic databases

eggNOGiCOG2038.
HOGENOMiHOG000263500.
KOiK00768.
OMAiYPQAVTG.
OrthoDBiEOG6HF61K.

Family and domain databases

Gene3Di1.10.1610.10. 1 hit.
HAMAPiMF_00230. CobT.
InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamiPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMiSSF52733. SSF52733. 1 hit.
TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FZR5-1 [UniParc]FASTAAdd to Basket

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MFNISPANHE FDDEIQSKID NKTKPLGALG ELENLAKQLA LVLGKDKPEI    50
INPKLLVFAA DHGIASSGVS IAPSEVTTQM VMNFVAGGAA INVFCRQVGL 100
DMEVIDCGIL QPLEGVEGVI DQRLGAGTGA IHKQAAMTLG AVKQGLEMAR 150
TRIELHHQQG CNLIALGEMG IGNTSSAAAI MATVMGMKGV DCVGRGTGID 200
AATLKRKQML VEQALHIHEA ELTDPYNILA CLGGFEIVQM TGAMLAAAER 250
NMLVIVDGFI ATAAAMVAVQ INANVRDYMI FGHQSDERGH CLMMEHLQAR 300
PLLRLGMRLG EGSGAVLALP LIRAAAGFYN EMASFSDAGI EI 342
Length:342
Mass (Da):36,215
Last modified:November 13, 2007 - v1
Checksum:i692789F995633F1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV38338.1.
RefSeqiWP_012144068.1. NC_009831.1.
YP_001475466.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV38338; ABV38338; Ssed_3734.
GeneIDi5614185.
KEGGisse:Ssed_3734.
PATRICi23565320. VBISheSed62411_3960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV38338.1 .
RefSeqi WP_012144068.1. NC_009831.1.
YP_001475466.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8FZR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_3734.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV38338 ; ABV38338 ; Ssed_3734 .
GeneIDi 5614185.
KEGGi sse:Ssed_3734.
PATRICi 23565320. VBISheSed62411_3960.

Phylogenomic databases

eggNOGi COG2038.
HOGENOMi HOG000263500.
KOi K00768.
OMAi YPQAVTG.
OrthoDBi EOG6HF61K.

Enzyme and pathway databases

UniPathwayi UPA00061 ; UER00516 .
BioCyci SSED425104:GH7Q-3868-MONOMER.

Family and domain databases

Gene3Di 1.10.1610.10. 1 hit.
HAMAPi MF_00230. CobT.
InterProi IPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view ]
Pfami PF02277. DBI_PRT. 1 hit.
[Graphical view ]
SUPFAMi SSF52733. SSF52733. 1 hit.
TIGRFAMsi TIGR03160. cobT_DBIPRT. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiCOBT_SHESH
AccessioniPrimary (citable) accession number: A8FZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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