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A8FZK4 (GCSP_SHESH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Ssed_3673
OrganismShewanella sediminis (strain HAW-EB3) [Complete proteome] [HAMAP]
Taxonomic identifier425104 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 962962Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000083216

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A8FZK4 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: F1195EA8A91A8E2F

FASTA962104,778
        10         20         30         40         50         60 
MTTETLTQLE QHELFIRRHI GPDSAQQQEM LNFVGAESLE DLTQQIVPES IRLNRDLAVG 

        70         80         90        100        110        120 
SACGEAEGMA YIREIADKNK VFKSYIGMGY YGTEVPSVIQ RNVLENPGWY TAYTPYQPEI 

       130        140        150        160        170        180 
AQGRLEAILN FQQVSMDLTG LDLASASLLD EATAAAEAMA LAKRVSKAKK ANIFFVADDV 

       190        200        210        220        230        240 
FPQTLDVVKT RAECFGFEIV VGPASEAVNY ELFGALFQYT NRFGEITDFT ELFTELKAKK 

       250        260        270        280        290        300 
AVVSVAADIM SLVMLKSPGS MGADVVFGSA QRFGVPMGLG GPHAAFFVTR DAHKRSLPGR 

       310        320        330        340        350        360 
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV YHGPQGLKII 

       370        380        390        400        410        420 
AERIHRLTDI LASGLTAKGV ELVNGTWFDT LSLKATDSEA ITARAVAAGI NLRIDSDGVL 

       430        440        450        460        470        480 
GVSLAETTLR EDIAELFDVI LGEGHGLDVA ALDAEIIKAG SSSIPAQLVR TDAILTHPTF 

       490        500        510        520        530        540 
NSYHSETEMM RYIKRLENKD LALNHSMISL GSCTMKLNAA TEMMPISWPE FGNMHPFCPL 

       550        560        570        580        590        600 
DQSEGYTDLI EELSTWLVDI TGYDAMCMQA NSGASGEYAG LLAIRNYHIS RGDAHRNVCL 

       610        620        630        640        650        660 
IPQSAHGTNP ASAQMAGMKI VVTACDKAGN VDMEDLKAKA AEVAENLSCI MITYPSTHGV 

       670        680        690        700        710        720 
YEETVSEICE VIHQHGGQVY LDGANMNAQV GLTTPGSIGA DVSHLNLHKT FAIPHGGGGP 

       730        740        750        760        770        780 
GMGPIGVKAH LAPFVAGHVV VKHGRESDNN GAVSAAPYGS ASILPITWMY IKLLGHQGLR 

       790        800        810        820        830        840 
QSTQVALLNA NYVMKKLSEH YPVLYTGRNE RVAHECIIDL RPLKESSGVT EMDIAKRLND 

       850        860        870        880        890        900 
YGFHAPTMSF PVAGTLMIEP TESESKVELD RFIEAMISIR GEASRVESGE WPADNNPLHN 

       910        920        930        940        950        960 
APHTLADIMD PEFDSRPYSR EVAVFPTAAV KLNKFWPTVN RIDDVFGDRN LFCACVPMSE 


YE 

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References

[1]"Complete sequence of Shewanella sediminis HAW-EB3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Zhao J.-S., Richardson P.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAW-EB3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000821 Genomic DNA. Translation: ABV38277.1.
RefSeqYP_001475405.1. NC_009831.1.

3D structure databases

ProteinModelPortalA8FZK4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING425104.Ssed_3673.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV38277; ABV38277; Ssed_3673.
GeneID5613653.
KEGGsse:Ssed_3673.
PATRIC23565192. VBISheSed62411_3897.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycSSED425104:GH7Q-3806-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SHESH
AccessionPrimary (citable) accession number: A8FZK4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families