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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-3806-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Ssed_3673
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000083216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi425104.Ssed_3673.

Structurei

3D structure databases

ProteinModelPortaliA8FZK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FZK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTETLTQLE QHELFIRRHI GPDSAQQQEM LNFVGAESLE DLTQQIVPES
60 70 80 90 100
IRLNRDLAVG SACGEAEGMA YIREIADKNK VFKSYIGMGY YGTEVPSVIQ
110 120 130 140 150
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEIV
210 220 230 240 250
VGPASEAVNY ELFGALFQYT NRFGEITDFT ELFTELKAKK AVVSVAADIM
260 270 280 290 300
SLVMLKSPGS MGADVVFGSA QRFGVPMGLG GPHAAFFVTR DAHKRSLPGR
310 320 330 340 350
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
YHGPQGLKII AERIHRLTDI LASGLTAKGV ELVNGTWFDT LSLKATDSEA
410 420 430 440 450
ITARAVAAGI NLRIDSDGVL GVSLAETTLR EDIAELFDVI LGEGHGLDVA
460 470 480 490 500
ALDAEIIKAG SSSIPAQLVR TDAILTHPTF NSYHSETEMM RYIKRLENKD
510 520 530 540 550
LALNHSMISL GSCTMKLNAA TEMMPISWPE FGNMHPFCPL DQSEGYTDLI
560 570 580 590 600
EELSTWLVDI TGYDAMCMQA NSGASGEYAG LLAIRNYHIS RGDAHRNVCL
610 620 630 640 650
IPQSAHGTNP ASAQMAGMKI VVTACDKAGN VDMEDLKAKA AEVAENLSCI
660 670 680 690 700
MITYPSTHGV YEETVSEICE VIHQHGGQVY LDGANMNAQV GLTTPGSIGA
710 720 730 740 750
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHVV VKHGRESDNN
760 770 780 790 800
GAVSAAPYGS ASILPITWMY IKLLGHQGLR QSTQVALLNA NYVMKKLSEH
810 820 830 840 850
YPVLYTGRNE RVAHECIIDL RPLKESSGVT EMDIAKRLND YGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESESKVELD RFIEAMISIR GEASRVESGE WPADNNPLHN
910 920 930 940 950
APHTLADIMD PEFDSRPYSR EVAVFPTAAV KLNKFWPTVN RIDDVFGDRN
960
LFCACVPMSE YE
Length:962
Mass (Da):104,778
Last modified:November 13, 2007 - v1
Checksum:iF1195EA8A91A8E2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV38277.1.
RefSeqiWP_012144007.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV38277; ABV38277; Ssed_3673.
KEGGisse:Ssed_3673.
PATRICi23565192. VBISheSed62411_3897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV38277.1.
RefSeqiWP_012144007.1. NC_009831.1.

3D structure databases

ProteinModelPortaliA8FZK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi425104.Ssed_3673.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV38277; ABV38277; Ssed_3673.
KEGGisse:Ssed_3673.
PATRICi23565192. VBISheSed62411_3897.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-3806-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiGCSP_SHESH
AccessioniPrimary (citable) accession number: A8FZK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: July 22, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.