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A8FZK4

- GCSP_SHESH

UniProt

A8FZK4 - GCSP_SHESH

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Ssed_3673
Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-3806-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Ssed_3673
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000083216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi425104.Ssed_3673.

Structurei

3D structure databases

ProteinModelPortaliA8FZK4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FZK4-1 [UniParc]FASTAAdd to Basket

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MTTETLTQLE QHELFIRRHI GPDSAQQQEM LNFVGAESLE DLTQQIVPES    50
IRLNRDLAVG SACGEAEGMA YIREIADKNK VFKSYIGMGY YGTEVPSVIQ 100
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEIV 200
VGPASEAVNY ELFGALFQYT NRFGEITDFT ELFTELKAKK AVVSVAADIM 250
SLVMLKSPGS MGADVVFGSA QRFGVPMGLG GPHAAFFVTR DAHKRSLPGR 300
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
YHGPQGLKII AERIHRLTDI LASGLTAKGV ELVNGTWFDT LSLKATDSEA 400
ITARAVAAGI NLRIDSDGVL GVSLAETTLR EDIAELFDVI LGEGHGLDVA 450
ALDAEIIKAG SSSIPAQLVR TDAILTHPTF NSYHSETEMM RYIKRLENKD 500
LALNHSMISL GSCTMKLNAA TEMMPISWPE FGNMHPFCPL DQSEGYTDLI 550
EELSTWLVDI TGYDAMCMQA NSGASGEYAG LLAIRNYHIS RGDAHRNVCL 600
IPQSAHGTNP ASAQMAGMKI VVTACDKAGN VDMEDLKAKA AEVAENLSCI 650
MITYPSTHGV YEETVSEICE VIHQHGGQVY LDGANMNAQV GLTTPGSIGA 700
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHVV VKHGRESDNN 750
GAVSAAPYGS ASILPITWMY IKLLGHQGLR QSTQVALLNA NYVMKKLSEH 800
YPVLYTGRNE RVAHECIIDL RPLKESSGVT EMDIAKRLND YGFHAPTMSF 850
PVAGTLMIEP TESESKVELD RFIEAMISIR GEASRVESGE WPADNNPLHN 900
APHTLADIMD PEFDSRPYSR EVAVFPTAAV KLNKFWPTVN RIDDVFGDRN 950
LFCACVPMSE YE 962
Length:962
Mass (Da):104,778
Last modified:November 13, 2007 - v1
Checksum:iF1195EA8A91A8E2F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV38277.1.
RefSeqiWP_012144007.1. NC_009831.1.
YP_001475405.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV38277; ABV38277; Ssed_3673.
GeneIDi5613653.
KEGGisse:Ssed_3673.
PATRICi23565192. VBISheSed62411_3897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV38277.1 .
RefSeqi WP_012144007.1. NC_009831.1.
YP_001475405.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8FZK4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_3673.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV38277 ; ABV38277 ; Ssed_3673 .
GeneIDi 5613653.
KEGGi sse:Ssed_3673.
PATRICi 23565192. VBISheSed62411_3897.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SSED425104:GH7Q-3806-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiGCSP_SHESH
AccessioniPrimary (citable) accession number: A8FZK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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