Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSSED425104:G1G9Y-3906-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Ssed_3673
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000832161 – 962Glycine dehydrogenase (decarboxylating)Add BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei709N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA8FZK4

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi425104.Ssed_3673

Structurei

3D structure databases

ProteinModelPortaliA8FZK4
SMRiA8FZK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A8FZK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTETLTQLE QHELFIRRHI GPDSAQQQEM LNFVGAESLE DLTQQIVPES
60 70 80 90 100
IRLNRDLAVG SACGEAEGMA YIREIADKNK VFKSYIGMGY YGTEVPSVIQ
110 120 130 140 150
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEIV
210 220 230 240 250
VGPASEAVNY ELFGALFQYT NRFGEITDFT ELFTELKAKK AVVSVAADIM
260 270 280 290 300
SLVMLKSPGS MGADVVFGSA QRFGVPMGLG GPHAAFFVTR DAHKRSLPGR
310 320 330 340 350
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
YHGPQGLKII AERIHRLTDI LASGLTAKGV ELVNGTWFDT LSLKATDSEA
410 420 430 440 450
ITARAVAAGI NLRIDSDGVL GVSLAETTLR EDIAELFDVI LGEGHGLDVA
460 470 480 490 500
ALDAEIIKAG SSSIPAQLVR TDAILTHPTF NSYHSETEMM RYIKRLENKD
510 520 530 540 550
LALNHSMISL GSCTMKLNAA TEMMPISWPE FGNMHPFCPL DQSEGYTDLI
560 570 580 590 600
EELSTWLVDI TGYDAMCMQA NSGASGEYAG LLAIRNYHIS RGDAHRNVCL
610 620 630 640 650
IPQSAHGTNP ASAQMAGMKI VVTACDKAGN VDMEDLKAKA AEVAENLSCI
660 670 680 690 700
MITYPSTHGV YEETVSEICE VIHQHGGQVY LDGANMNAQV GLTTPGSIGA
710 720 730 740 750
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHVV VKHGRESDNN
760 770 780 790 800
GAVSAAPYGS ASILPITWMY IKLLGHQGLR QSTQVALLNA NYVMKKLSEH
810 820 830 840 850
YPVLYTGRNE RVAHECIIDL RPLKESSGVT EMDIAKRLND YGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESESKVELD RFIEAMISIR GEASRVESGE WPADNNPLHN
910 920 930 940 950
APHTLADIMD PEFDSRPYSR EVAVFPTAAV KLNKFWPTVN RIDDVFGDRN
960
LFCACVPMSE YE
Length:962
Mass (Da):104,778
Last modified:November 13, 2007 - v1
Checksum:iF1195EA8A91A8E2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA Translation: ABV38277.1
RefSeqiWP_012144007.1, NC_009831.1

Genome annotation databases

EnsemblBacteriaiABV38277; ABV38277; Ssed_3673
KEGGisse:Ssed_3673

Similar proteinsi

Entry informationi

Entry nameiGCSP_SHESH
AccessioniPrimary (citable) accession number: A8FZK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health