SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8FZ10

- SYL_SHESH

UniProt

A8FZ10 - SYL_SHESH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Leucine--tRNA ligase
Gene
leuS, Ssed_3479
Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-3607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Ssed_3479
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligaseUniRule annotation
PRO_1000074844Add
BLAST

Proteomic databases

PRIDEiA8FZ10.

Interactioni

Protein-protein interaction databases

STRINGi425104.Ssed_3479.

Structurei

3D structure databases

ProteinModelPortaliA8FZ10.
SMRiA8FZ10. Positions 228-416.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi622 – 6265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYAANYIL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8FZ10-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYKPSEI EAKVQQHWQD KKTFEVTEDE NKEKFYCLSM FPYPSGRLHM    50
GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA IKNNTAPAPW 100
TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLFEKGLVY 150
KKTASVNWCP NDETVLANEQ VIDGCCWRCD TTVEQKEIPQ WFIKITEYAD 200
ELLKDIDQLD EWPEQVKTMQ RNWIGRSEGI EMTFGVVDSE ETFDIYTTRP 250
DTVMGVTYVA IAAGHPLAEK AAANNSELSD FIEECKNADT TEAAMAAMEK 300
KGVATGLYAT HPLTGKQVPI WAANFVLMNY GTGAVMSVPA HDQRDYEFAT 350
KYGLAIEGVI KPSDSDLDIS EEAYTEKGVL FNSGDSFPEL DGLDFQDAFD 400
AIDAKLSSEG KGKRQVNFRL RDWGVSRQRY WGAPIPMVTL ADGTVVPTPE 450
DQLPVILPED VVMDGIQSPI KADKEWAKTQ INGQEAFRET DTFDTFMESS 500
WYYARYCSPH ADEMLDPAKA NYWLPVDQYI GGIEHACMHL LYFRFFHKLL 550
RDIGLVNSDE PAKRLLTQGM VLADAFYYNN EKGARVWVAP SDVTVQETDE 600
KGRIQKAVDS EGHELVYTGM SKMSKSKNNG IDPQVMVDKY GADTVRLFMM 650
FAAPPELTLE WQESSVEGAH RFIKRLWKVA HDHVAKGATA PLDVKTLDTK 700
QKELRRELHK TIVKVGDDIE RRQMFNTAIA SVMELMNRLQ KAPTETQQDR 750
ALMQEALSAV VRLLYPIIPH TSFSLWNDLG NEENIEDVRW PEADQSALVE 800
DSKLIIVQVN GKLRAKITVP ADATKEVVEE QGFAEEGVIK HTEGKTVRKV 850
IYVPGKLLNI VAN 863
Length:863
Mass (Da):98,073
Last modified:November 13, 2007 - v1
Checksum:iFFC1C92C73295E86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV38083.1.
RefSeqiWP_012143813.1. NC_009831.1.
YP_001475211.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV38083; ABV38083; Ssed_3479.
GeneIDi5613276.
KEGGisse:Ssed_3479.
PATRICi23564770. VBISheSed62411_3691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV38083.1 .
RefSeqi WP_012143813.1. NC_009831.1.
YP_001475211.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8FZ10.
SMRi A8FZ10. Positions 228-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_3479.

Proteomic databases

PRIDEi A8FZ10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV38083 ; ABV38083 ; Ssed_3479 .
GeneIDi 5613276.
KEGGi sse:Ssed_3479.
PATRICi 23564770. VBISheSed62411_3691.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YAANYIL.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSED425104:GH7Q-3607-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiSYL_SHESH
AccessioniPrimary (citable) accession number: A8FZ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi