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A8FZ10

- SYL_SHESH

UniProt

A8FZ10 - SYL_SHESH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-3607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Ssed_3479
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligasePRO_1000074844Add
BLAST

Proteomic databases

PRIDEiA8FZ10.

Interactioni

Protein-protein interaction databases

STRINGi425104.Ssed_3479.

Structurei

3D structure databases

ProteinModelPortaliA8FZ10.
SMRiA8FZ10. Positions 228-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi622 – 6265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYAANYIL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8FZ10-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYKPSEI EAKVQQHWQD KKTFEVTEDE NKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA IKNNTAPAPW
110 120 130 140 150
TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLFEKGLVY
160 170 180 190 200
KKTASVNWCP NDETVLANEQ VIDGCCWRCD TTVEQKEIPQ WFIKITEYAD
210 220 230 240 250
ELLKDIDQLD EWPEQVKTMQ RNWIGRSEGI EMTFGVVDSE ETFDIYTTRP
260 270 280 290 300
DTVMGVTYVA IAAGHPLAEK AAANNSELSD FIEECKNADT TEAAMAAMEK
310 320 330 340 350
KGVATGLYAT HPLTGKQVPI WAANFVLMNY GTGAVMSVPA HDQRDYEFAT
360 370 380 390 400
KYGLAIEGVI KPSDSDLDIS EEAYTEKGVL FNSGDSFPEL DGLDFQDAFD
410 420 430 440 450
AIDAKLSSEG KGKRQVNFRL RDWGVSRQRY WGAPIPMVTL ADGTVVPTPE
460 470 480 490 500
DQLPVILPED VVMDGIQSPI KADKEWAKTQ INGQEAFRET DTFDTFMESS
510 520 530 540 550
WYYARYCSPH ADEMLDPAKA NYWLPVDQYI GGIEHACMHL LYFRFFHKLL
560 570 580 590 600
RDIGLVNSDE PAKRLLTQGM VLADAFYYNN EKGARVWVAP SDVTVQETDE
610 620 630 640 650
KGRIQKAVDS EGHELVYTGM SKMSKSKNNG IDPQVMVDKY GADTVRLFMM
660 670 680 690 700
FAAPPELTLE WQESSVEGAH RFIKRLWKVA HDHVAKGATA PLDVKTLDTK
710 720 730 740 750
QKELRRELHK TIVKVGDDIE RRQMFNTAIA SVMELMNRLQ KAPTETQQDR
760 770 780 790 800
ALMQEALSAV VRLLYPIIPH TSFSLWNDLG NEENIEDVRW PEADQSALVE
810 820 830 840 850
DSKLIIVQVN GKLRAKITVP ADATKEVVEE QGFAEEGVIK HTEGKTVRKV
860
IYVPGKLLNI VAN
Length:863
Mass (Da):98,073
Last modified:November 13, 2007 - v1
Checksum:iFFC1C92C73295E86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV38083.1.
RefSeqiYP_001475211.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV38083; ABV38083; Ssed_3479.
GeneIDi5613276.
KEGGisse:Ssed_3479.
PATRICi23564770. VBISheSed62411_3691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV38083.1 .
RefSeqi YP_001475211.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8FZ10.
SMRi A8FZ10. Positions 228-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_3479.

Proteomic databases

PRIDEi A8FZ10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV38083 ; ABV38083 ; Ssed_3479 .
GeneIDi 5613276.
KEGGi sse:Ssed_3479.
PATRICi 23564770. VBISheSed62411_3691.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YAANYIL.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSED425104:GH7Q-3607-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiSYL_SHESH
AccessioniPrimary (citable) accession number: A8FZ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3