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A8FZ10

- SYL_SHESH

UniProt

A8FZ10 - SYL_SHESH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSED425104:GH7Q-3607-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Ssed_3479
    OrganismiShewanella sediminis (strain HAW-EB3)
    Taxonomic identifieri425104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002015: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Leucine--tRNA ligasePRO_1000074844Add
    BLAST

    Proteomic databases

    PRIDEiA8FZ10.

    Interactioni

    Protein-protein interaction databases

    STRINGi425104.Ssed_3479.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FZ10.
    SMRiA8FZ10. Positions 228-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiYAANYIL.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8FZ10-1 [UniParc]FASTAAdd to Basket

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    MQEQYKPSEI EAKVQQHWQD KKTFEVTEDE NKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA IKNNTAPAPW 100
    TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLFEKGLVY 150
    KKTASVNWCP NDETVLANEQ VIDGCCWRCD TTVEQKEIPQ WFIKITEYAD 200
    ELLKDIDQLD EWPEQVKTMQ RNWIGRSEGI EMTFGVVDSE ETFDIYTTRP 250
    DTVMGVTYVA IAAGHPLAEK AAANNSELSD FIEECKNADT TEAAMAAMEK 300
    KGVATGLYAT HPLTGKQVPI WAANFVLMNY GTGAVMSVPA HDQRDYEFAT 350
    KYGLAIEGVI KPSDSDLDIS EEAYTEKGVL FNSGDSFPEL DGLDFQDAFD 400
    AIDAKLSSEG KGKRQVNFRL RDWGVSRQRY WGAPIPMVTL ADGTVVPTPE 450
    DQLPVILPED VVMDGIQSPI KADKEWAKTQ INGQEAFRET DTFDTFMESS 500
    WYYARYCSPH ADEMLDPAKA NYWLPVDQYI GGIEHACMHL LYFRFFHKLL 550
    RDIGLVNSDE PAKRLLTQGM VLADAFYYNN EKGARVWVAP SDVTVQETDE 600
    KGRIQKAVDS EGHELVYTGM SKMSKSKNNG IDPQVMVDKY GADTVRLFMM 650
    FAAPPELTLE WQESSVEGAH RFIKRLWKVA HDHVAKGATA PLDVKTLDTK 700
    QKELRRELHK TIVKVGDDIE RRQMFNTAIA SVMELMNRLQ KAPTETQQDR 750
    ALMQEALSAV VRLLYPIIPH TSFSLWNDLG NEENIEDVRW PEADQSALVE 800
    DSKLIIVQVN GKLRAKITVP ADATKEVVEE QGFAEEGVIK HTEGKTVRKV 850
    IYVPGKLLNI VAN 863
    Length:863
    Mass (Da):98,073
    Last modified:November 13, 2007 - v1
    Checksum:iFFC1C92C73295E86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV38083.1.
    RefSeqiWP_012143813.1. NC_009831.1.
    YP_001475211.1. NC_009831.1.

    Genome annotation databases

    EnsemblBacteriaiABV38083; ABV38083; Ssed_3479.
    GeneIDi5613276.
    KEGGisse:Ssed_3479.
    PATRICi23564770. VBISheSed62411_3691.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV38083.1 .
    RefSeqi WP_012143813.1. NC_009831.1.
    YP_001475211.1. NC_009831.1.

    3D structure databases

    ProteinModelPortali A8FZ10.
    SMRi A8FZ10. Positions 228-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 425104.Ssed_3479.

    Proteomic databases

    PRIDEi A8FZ10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV38083 ; ABV38083 ; Ssed_3479 .
    GeneIDi 5613276.
    KEGGi sse:Ssed_3479.
    PATRICi 23564770. VBISheSed62411_3691.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi YAANYIL.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SSED425104:GH7Q-3607-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB3.

    Entry informationi

    Entry nameiSYL_SHESH
    AccessioniPrimary (citable) accession number: A8FZ10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3