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A8FYW3

- LUXS_SHESH

UniProt

A8FYW3 - LUXS_SHESH

Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

    Catalytic activityi

    S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

    Cofactori

    Binds 1 iron ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541IronUniRule annotation
    Metal bindingi58 – 581IronUniRule annotation
    Metal bindingi128 – 1281IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. quorum sensing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Autoinducer synthesis, Quorum sensing

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSSED425104:GH7Q-3552-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
    Alternative name(s):
    AI-2 synthesis proteinUniRule annotation
    Autoinducer-2 production protein LuxSUniRule annotation
    Gene namesi
    Name:luxSUniRule annotation
    Ordered Locus Names:Ssed_3432
    OrganismiShewanella sediminis (strain HAW-EB3)
    Taxonomic identifieri425104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002015: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 169169S-ribosylhomocysteine lyasePRO_1000075461Add
    BLAST

    Proteomic databases

    PRIDEiA8FYW3.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi425104.Ssed_3432.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FYW3.
    SMRiA8FYW3. Positions 3-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LuxS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1854.
    HOGENOMiHOG000040371.
    KOiK07173.
    OMAiAWLASMN.
    OrthoDBiEOG68WRBM.

    Family and domain databases

    Gene3Di3.30.1360.80. 1 hit.
    HAMAPiMF_00091. LuxS.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view]
    PfamiPF02664. LuxS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006160. AI2. 1 hit.
    PRINTSiPR01487. LUXSPROTEIN.
    ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF63411. SSF63411. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8FYW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLLDSFTVD HTRMQAPAVR IAKTMKTPKG DVITVFDLRF CVPNKEILSE    50
    RGIHTLEHLY AGFMRDHLNG DSVEIIDISP MGCRTGFYMS LIGTPAEADV 100
    AQAWLASMND VLKVAEQAQI PELNEYQCGT FDMHSLDQAQ SIARSIIAAG 150
    ITVNKNDELK LSDEILNGL 169
    Length:169
    Mass (Da):18,679
    Last modified:November 13, 2007 - v1
    Checksum:iF7E1C5BA2A9CCE3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV38036.1.
    RefSeqiWP_012143766.1. NC_009831.1.
    YP_001475164.1. NC_009831.1.

    Genome annotation databases

    EnsemblBacteriaiABV38036; ABV38036; Ssed_3432.
    GeneIDi5610442.
    KEGGisse:Ssed_3432.
    PATRICi23564660. VBISheSed62411_3644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV38036.1 .
    RefSeqi WP_012143766.1. NC_009831.1.
    YP_001475164.1. NC_009831.1.

    3D structure databases

    ProteinModelPortali A8FYW3.
    SMRi A8FYW3. Positions 3-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 425104.Ssed_3432.

    Proteomic databases

    PRIDEi A8FYW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV38036 ; ABV38036 ; Ssed_3432 .
    GeneIDi 5610442.
    KEGGi sse:Ssed_3432.
    PATRICi 23564660. VBISheSed62411_3644.

    Phylogenomic databases

    eggNOGi COG1854.
    HOGENOMi HOG000040371.
    KOi K07173.
    OMAi AWLASMN.
    OrthoDBi EOG68WRBM.

    Enzyme and pathway databases

    BioCyci SSED425104:GH7Q-3552-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.80. 1 hit.
    HAMAPi MF_00091. LuxS.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view ]
    Pfami PF02664. LuxS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006160. AI2. 1 hit.
    PRINTSi PR01487. LUXSPROTEIN.
    ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF63411. SSF63411. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB3.

    Entry informationi

    Entry nameiLUXS_SHESH
    AccessioniPrimary (citable) accession number: A8FYW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3