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A8FY29

- LPXB_SHESH

UniProt

A8FY29 - LPXB_SHESH

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSSED425104:GH7Q-3266-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Ssed_3148
    OrganismiShewanella sediminis (strain HAW-EB3)
    Taxonomic identifieri425104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002015: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Lipid-A-disaccharide synthasePRO_1000080286Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi425104.Ssed_3148.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FY29.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8FY29-1 [UniParc]FASTAAdd to Basket

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    MSETTHPTFA MVAGELSGDI LGAGLIKALQ HQYPDARFVG IGGPRMEALG    50
    FESIFSFEEL AVMGIVEVLS RLQRLLKVRK TLIDEICSIE PACFIGIDAP 100
    DFNIGLELKL KARGIKTVHY VSPSVWAWRP KRIFKIAKAT DMVLSLLPFE 150
    KAFYDKHDVP CTFVGHTLAD DIPLISDKTA ARNLLGLDAD AEYLAVLPGS 200
    RGGELKQLAE PFVKAASLIK KRYPDIRFVT PLVNQKRREQ FEEALKLHAP 250
    DLEITLVEGH SREVMAASDC ILLASGTATL EAMLVKRPMV VAYRVSPITY 300
    KIAKGMMQID QYSLPNLLSG ETLVTELIQE NCTESLIADA ISEQLDSDFS 350
    PLKEKFMQLH KGLKCNASER AAEAVIKLIQ 380
    Length:380
    Mass (Da):42,011
    Last modified:November 13, 2007 - v1
    Checksum:i8EE224D7DF3C63EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV37752.1.
    RefSeqiYP_001474880.1. NC_009831.1.

    Genome annotation databases

    EnsemblBacteriaiABV37752; ABV37752; Ssed_3148.
    GeneIDi5610179.
    KEGGisse:Ssed_3148.
    PATRICi23564057. VBISheSed62411_3345.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV37752.1 .
    RefSeqi YP_001474880.1. NC_009831.1.

    3D structure databases

    ProteinModelPortali A8FY29.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 425104.Ssed_3148.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV37752 ; ABV37752 ; Ssed_3148 .
    GeneIDi 5610179.
    KEGGi sse:Ssed_3148.
    PATRICi 23564057. VBISheSed62411_3345.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci SSED425104:GH7Q-3266-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB3.

    Entry informationi

    Entry nameiLPXB_SHESH
    AccessioniPrimary (citable) accession number: A8FY29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3