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Protein

Protein-L-isoaspartate O-methyltransferase 2

Gene

pcm2

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSSED425104:G1G9Y-2974-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase 2UniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase 2UniRule annotation
Protein L-isoaspartyl methyltransferase 2UniRule annotation
Protein-beta-aspartate methyltransferase 2UniRule annotation
Short name:
PIMT 2UniRule annotation
Gene namesi
Name:pcm2UniRule annotation
Ordered Locus Names:Ssed_2790
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002015 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003519371 – 244Protein-L-isoaspartate O-methyltransferase 2Add BLAST244

Interactioni

Protein-protein interaction databases

STRINGi425104.Ssed_2790

Structurei

3D structure databases

ProteinModelPortaliA8FX24
SMRiA8FX24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KE4 Bacteria
COG2518 LUCA
HOGENOMiHOG000257189
KOiK00573
OMAiYSSRTIP
OrthoDBiPOG091H06AY

Family and domain databases

HAMAPiMF_00090 PIMT, 1 hit
InterProiView protein in InterPro
IPR000682 PCMT
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11579 PTHR11579, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00080 pimt, 1 hit
PROSITEiView protein in PROSITE
PS01279 PCMT, 1 hit

Sequencei

Sequence statusi: Complete.

A8FX24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLLFLFIT LILFEQQSLA ALPTGDSEKY LRARESMVQN QLSTRDIKDK
60 70 80 90 100
RVLTAMREVP RHLFVPDLLV FKAYTDSPLP IGEGQTISQP YIVALMTELL
110 120 130 140 150
ELTGSERVLE IGTGSGYQAA VLSQVAKEVF TIEIKEKLCT KAGKLLDSLG
160 170 180 190 200
YTNIQARCGD GYFGWNKEAP FDAIMITAAV DHVPPPLLAQ LKDGGRLVLP
210 220 230 240
LGNPFSYQNL VLVTRKGDDY RVWQISGVLF VPMTGHALKD SGEK
Length:244
Mass (Da):26,988
Last modified:November 13, 2007 - v1
Checksum:iCA08CB97E6652052
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA Translation: ABV37397.1
RefSeqiWP_012143127.1, NC_009831.1

Genome annotation databases

EnsemblBacteriaiABV37397; ABV37397; Ssed_2790
KEGGisse:Ssed_2790

Similar proteinsi

Entry informationi

Entry nameiPIMT2_SHESH
AccessioniPrimary (citable) accession number: A8FX24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health