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A8FWK2

- CDD_SHESH

UniProt

A8FWK2 - CDD_SHESH

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Protein
Cytidine deaminase
Gene
cdd, Ssed_2618
Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Binds 1 zinc ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Zinc; catalytic By similarity
Active sitei103 – 1031Proton donor By similarity
Metal bindingi128 – 1281Zinc; catalytic By similarity
Metal bindingi131 – 1311Zinc; catalytic By similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSSED425104:GH7Q-2716-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminase (EC:3.5.4.5)
    Alternative name(s):
    Cytidine aminohydrolase
    Short name:
    CDA
    Gene namesi
    Name:cdd
    Ordered Locus Names:Ssed_2618
    OrganismiShewanella sediminis (strain HAW-EB3)
    Taxonomic identifieri425104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002015: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Cytidine deaminaseUniRule annotation
    PRO_1000087800Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi425104.Ssed_2618.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FWK2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini57 – 13983CMP/dCMP deaminase zinc-binding
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni88 – 903Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    HOGENOMiHOG000218617.
    KOiK01489.
    OMAiNRSHAPY.
    OrthoDBiEOG6XDH25.

    Family and domain databases

    HAMAPiMF_01558. Cyt_deam.
    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMiSSF53927. SSF53927. 2 hits.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8FWK2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDRFIKCIA ELPKPLSDAL VPMLNAEFAG HIDAQQLSTL ITKSGLAESE    50
    LLIALLPVAA ALARPPISEF YVGAIAKGKS GDIYMGANME LSGEALFHSV 100
    HAEQSAISHA WLSGERQIED VIVNFSPCGH CRQFMNELVE GQKVKIHLPE 150
    QQTQPLSHYL PYAFGPSDLN ITEPLLTKQQ HELSLDSSDP MIIEALDHAS 200
    LSYAPYTNSY AAVVLETQDG ATYCGRYAEN AAFNPSMLPM QMALSTMARH 250
    NREFCEISRA VLIESAGGKI SLVGATMDAL HAVAAVELEH IVLDPE 296
    Length:296
    Mass (Da):32,172
    Last modified:November 13, 2007 - v1
    Checksum:iEBF4763814FC2463
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV37225.1.
    RefSeqiYP_001474353.1. NC_009831.1.

    Genome annotation databases

    EnsemblBacteriaiABV37225; ABV37225; Ssed_2618.
    GeneIDi5610674.
    KEGGisse:Ssed_2618.
    PATRICi23562905. VBISheSed62411_2791.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV37225.1 .
    RefSeqi YP_001474353.1. NC_009831.1.

    3D structure databases

    ProteinModelPortali A8FWK2.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 425104.Ssed_2618.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV37225 ; ABV37225 ; Ssed_2618 .
    GeneIDi 5610674.
    KEGGi sse:Ssed_2618.
    PATRICi 23562905. VBISheSed62411_2791.

    Phylogenomic databases

    eggNOGi COG0295.
    HOGENOMi HOG000218617.
    KOi K01489.
    OMAi NRSHAPY.
    OrthoDBi EOG6XDH25.

    Enzyme and pathway databases

    BioCyci SSED425104:GH7Q-2716-MONOMER.

    Family and domain databases

    HAMAPi MF_01558. Cyt_deam.
    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMi SSF53927. SSF53927. 2 hits.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB3.

    Entry informationi

    Entry nameiCDD_SHESH
    AccessioniPrimary (citable) accession number: A8FWK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: May 14, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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