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A8FWC6

- A8FWC6_SHESH

UniProt

A8FWC6 - A8FWC6_SHESH

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotationSAAS annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei127 – 1271NADUniRule annotation
    Binding sitei185 – 1851NADUniRule annotation
    Binding sitei208 – 2081NADUniRule annotation
    Binding sitei235 – 2351SubstrateUniRule annotation
    Metal bindingi257 – 2571ZincUniRule annotation
    Binding sitei257 – 2571SubstrateUniRule annotation
    Metal bindingi260 – 2601ZincUniRule annotation
    Binding sitei260 – 2601SubstrateUniRule annotation
    Active sitei324 – 3241Proton acceptorUniRule annotation
    Active sitei325 – 3251Proton acceptorUniRule annotation
    Binding sitei325 – 3251SubstrateUniRule annotation
    Metal bindingi358 – 3581ZincUniRule annotation
    Binding sitei358 – 3581SubstrateUniRule annotation
    Binding sitei412 – 4121SubstrateUniRule annotation
    Metal bindingi417 – 4171ZincUniRule annotation
    Binding sitei417 – 4171SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSSED425104:GH7Q-2640-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:Ssed_2542Imported
    OrganismiShewanella sediminis (strain HAW-EB3)Imported
    Taxonomic identifieri425104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002015: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi425104.Ssed_2542.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FWC6.
    SMRiA8FWC6. Positions 2-431.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiSQDSRCV.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8FWC6-1 [UniParc]FASTAAdd to Basket

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    MQILNWASLT DTDRKAALSR SPLVGDASLE QDVLAIVNEV QIGKDAALKD    50
    YSRKFDGVTV EQLKLSEGDI DAACARVDEE IKLAVSQAIT NIDTFHQAQK 100
    FEPVNIETQK GIRCELRSEP IEKVGLYIPG GSAPLISTVL MLALPAKIAG 150
    CEQRVLVSPP PINDAIVYAA NACGITEILQ VGGAQAIAAL AFGTESVPAV 200
    DKIFGPGNRY VTEAKRIVSQ DSRCVVSIDM PAGPSEVLLI ADSDANAEFI 250
    AADLLSQAEH GPDSQVMLVT DCSALADEVN LALARQLELL PRVDIAEVAL 300
    ESSRTLLVEN MEQAAQVSNL YGPEHLIIQT QNPREVLKQI RAAGSVFLGA 350
    YTPESVGDYA SGTNHVLPTY GYSRAVSSLS LADFSRRFTV QELSAEGLIG 400
    LSQTVMTLAA AEQLDAHKNA VAIRIASLQS DVAAQAKGV 439
    Length:439
    Mass (Da):46,674
    Last modified:November 13, 2007 - v1
    Checksum:i1FA189C96C78C7EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV37149.1.
    RefSeqiWP_012142882.1. NC_009831.1.
    YP_001474277.1. NC_009831.1.

    Genome annotation databases

    EnsemblBacteriaiABV37149; ABV37149; Ssed_2542.
    GeneIDi5612964.
    KEGGisse:Ssed_2542.
    PATRICi23562755. VBISheSed62411_2716.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV37149.1 .
    RefSeqi WP_012142882.1. NC_009831.1.
    YP_001474277.1. NC_009831.1.

    3D structure databases

    ProteinModelPortali A8FWC6.
    SMRi A8FWC6. Positions 2-431.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 425104.Ssed_2542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV37149 ; ABV37149 ; Ssed_2542 .
    GeneIDi 5612964.
    KEGGi sse:Ssed_2542.
    PATRICi 23562755. VBISheSed62411_2716.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi SQDSRCV.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci SSED425104:GH7Q-2640-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB3Imported.

    Entry informationi

    Entry nameiA8FWC6_SHESH
    AccessioniPrimary (citable) accession number: A8FWC6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3