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A8FWC6 (A8FWC6_SHESH) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024 PIRNR PIRNR000099 SAAS SAAS001692

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024 PIRNR PIRNR000099 SAAS SAAS001692

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024 PIRSR PIRSR000099-4 SAAS SAAS001692

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024 PIRNR PIRNR000099 SAAS SAAS001692

Sequence similarities

Belongs to the histidinol dehydrogenase family. RuleBase RU004175 HAMAP-Rule MF_01024 PIRNR PIRNR000099

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3241Proton acceptor By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-1
Active site3251Proton acceptor By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-1
Metal binding2571Zinc By similarity HAMAP-Rule MF_01024
Metal binding2601Zinc By similarity HAMAP-Rule MF_01024
Metal binding3581Zinc By similarity HAMAP-Rule MF_01024
Metal binding4171Zinc By similarity HAMAP-Rule MF_01024
Binding site1271NAD By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-2
Binding site1851NAD By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-2
Binding site2081NAD By similarity HAMAP-Rule MF_01024 PIRSR PIRSR000099-2
Binding site2351Substrate By similarity PIRSR PIRSR000099-3 HAMAP-Rule MF_01024
Binding site2571Substrate By similarity PIRSR PIRSR000099-3 HAMAP-Rule MF_01024
Binding site2601Substrate By similarity PIRSR PIRSR000099-3 HAMAP-Rule MF_01024
Binding site3251Substrate By similarity PIRSR PIRSR000099-3 HAMAP-Rule MF_01024
Binding site3581Substrate By similarity PIRSR PIRSR000099-3 HAMAP-Rule MF_01024
Binding site4121Substrate By similarity PIRSR PIRSR000099-3 HAMAP-Rule MF_01024
Binding site4171Substrate By similarity PIRSR PIRSR000099-3 HAMAP-Rule MF_01024

Sequences

Sequence LengthMass (Da)Tools
A8FWC6 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 1FA189C96C78C7EB

FASTA43946,674
        10         20         30         40         50         60 
MQILNWASLT DTDRKAALSR SPLVGDASLE QDVLAIVNEV QIGKDAALKD YSRKFDGVTV 

        70         80         90        100        110        120 
EQLKLSEGDI DAACARVDEE IKLAVSQAIT NIDTFHQAQK FEPVNIETQK GIRCELRSEP 

       130        140        150        160        170        180 
IEKVGLYIPG GSAPLISTVL MLALPAKIAG CEQRVLVSPP PINDAIVYAA NACGITEILQ 

       190        200        210        220        230        240 
VGGAQAIAAL AFGTESVPAV DKIFGPGNRY VTEAKRIVSQ DSRCVVSIDM PAGPSEVLLI 

       250        260        270        280        290        300 
ADSDANAEFI AADLLSQAEH GPDSQVMLVT DCSALADEVN LALARQLELL PRVDIAEVAL 

       310        320        330        340        350        360 
ESSRTLLVEN MEQAAQVSNL YGPEHLIIQT QNPREVLKQI RAAGSVFLGA YTPESVGDYA 

       370        380        390        400        410        420 
SGTNHVLPTY GYSRAVSSLS LADFSRRFTV QELSAEGLIG LSQTVMTLAA AEQLDAHKNA 

       430 
VAIRIASLQS DVAAQAKGV 

« Hide

References

[1]"Complete sequence of Shewanella sediminis HAW-EB3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Zhao J.-S., Richardson P.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAW-EB3 EMBL ABV37149.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000821 Genomic DNA. Translation: ABV37149.1.
RefSeqYP_001474277.1. NC_009831.1.

3D structure databases

ProteinModelPortalA8FWC6.
SMRA8FWC6. Positions 2-431.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING425104.Ssed_2542.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV37149; ABV37149; Ssed_2542.
GeneID5612964.
KEGGsse:Ssed_2542.
PATRIC23562755. VBISheSed62411_2716.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
OrthoDBEOG6CVVCR.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycSSED425104:GH7Q-2640-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8FWC6_SHESH
AccessionPrimary (citable) accession number: A8FWC6
Entry history
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)