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A8FWC6

- A8FWC6_SHESH

UniProt

A8FWC6 - A8FWC6_SHESH

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Protein

Histidinol dehydrogenase

Gene
hisD, Ssed_2542
Organism
Shewanella sediminis (strain HAW-EB3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotationSAAS annotations

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarityUniRule annotation
Binding sitei185 – 1851NAD By similarityUniRule annotation
Binding sitei208 – 2081NAD By similarityUniRule annotation
Binding sitei235 – 2351Substrate By similarityUniRule annotation
Metal bindingi257 – 2571Zinc By similarityUniRule annotation
Binding sitei257 – 2571Substrate By similarityUniRule annotation
Metal bindingi260 – 2601Zinc By similarityUniRule annotation
Binding sitei260 – 2601Substrate By similarityUniRule annotation
Active sitei324 – 3241Proton acceptor By similarityUniRule annotation
Active sitei325 – 3251Proton acceptor By similarityUniRule annotation
Binding sitei325 – 3251Substrate By similarityUniRule annotation
Metal bindingi358 – 3581Zinc By similarityUniRule annotation
Binding sitei358 – 3581Substrate By similarityUniRule annotation
Binding sitei412 – 4121Substrate By similarityUniRule annotation
Metal bindingi417 – 4171Zinc By similarityUniRule annotation
Binding sitei417 – 4171Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, NADUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-2640-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Ssed_2542Imported
OrganismiShewanella sediminis (strain HAW-EB3)Imported
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi425104.Ssed_2542.

Structurei

3D structure databases

ProteinModelPortaliA8FWC6.
SMRiA8FWC6. Positions 2-431.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiSQDSRCV.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8FWC6-1 [UniParc]FASTAAdd to Basket

« Hide

MQILNWASLT DTDRKAALSR SPLVGDASLE QDVLAIVNEV QIGKDAALKD    50
YSRKFDGVTV EQLKLSEGDI DAACARVDEE IKLAVSQAIT NIDTFHQAQK 100
FEPVNIETQK GIRCELRSEP IEKVGLYIPG GSAPLISTVL MLALPAKIAG 150
CEQRVLVSPP PINDAIVYAA NACGITEILQ VGGAQAIAAL AFGTESVPAV 200
DKIFGPGNRY VTEAKRIVSQ DSRCVVSIDM PAGPSEVLLI ADSDANAEFI 250
AADLLSQAEH GPDSQVMLVT DCSALADEVN LALARQLELL PRVDIAEVAL 300
ESSRTLLVEN MEQAAQVSNL YGPEHLIIQT QNPREVLKQI RAAGSVFLGA 350
YTPESVGDYA SGTNHVLPTY GYSRAVSSLS LADFSRRFTV QELSAEGLIG 400
LSQTVMTLAA AEQLDAHKNA VAIRIASLQS DVAAQAKGV 439
Length:439
Mass (Da):46,674
Last modified:November 13, 2007 - v1
Checksum:i1FA189C96C78C7EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV37149.1.
RefSeqiWP_012142882.1. NC_009831.1.
YP_001474277.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV37149; ABV37149; Ssed_2542.
GeneIDi5612964.
KEGGisse:Ssed_2542.
PATRICi23562755. VBISheSed62411_2716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV37149.1 .
RefSeqi WP_012142882.1. NC_009831.1.
YP_001474277.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8FWC6.
SMRi A8FWC6. Positions 2-431.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_2542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV37149 ; ABV37149 ; Ssed_2542 .
GeneIDi 5612964.
KEGGi sse:Ssed_2542.
PATRICi 23562755. VBISheSed62411_2716.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi SQDSRCV.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SSED425104:GH7Q-2640-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3Imported.

Entry informationi

Entry nameiA8FWC6_SHESH
AccessioniPrimary (citable) accession number: A8FWC6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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