Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8FWC6

- A8FWC6_SHESH

UniProt

A8FWC6 - A8FWC6_SHESH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotationSAAS annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NADUniRule annotation
Binding sitei185 – 1851NADUniRule annotation
Binding sitei208 – 2081NADUniRule annotation
Binding sitei235 – 2351SubstrateUniRule annotation
Metal bindingi257 – 2571ZincUniRule annotation
Binding sitei257 – 2571SubstrateUniRule annotation
Metal bindingi260 – 2601ZincUniRule annotation
Binding sitei260 – 2601SubstrateUniRule annotation
Active sitei324 – 3241Proton acceptorUniRule annotation
Active sitei325 – 3251Proton acceptorUniRule annotation
Binding sitei325 – 3251SubstrateUniRule annotation
Metal bindingi358 – 3581ZincUniRule annotation
Binding sitei358 – 3581SubstrateUniRule annotation
Binding sitei412 – 4121SubstrateUniRule annotation
Metal bindingi417 – 4171ZincUniRule annotation
Binding sitei417 – 4171SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-2640-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Ssed_2542Imported
OrganismiShewanella sediminis (strain HAW-EB3)Imported
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi425104.Ssed_2542.

Structurei

3D structure databases

ProteinModelPortaliA8FWC6.
SMRiA8FWC6. Positions 2-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiSQDSRCV.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8FWC6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQILNWASLT DTDRKAALSR SPLVGDASLE QDVLAIVNEV QIGKDAALKD
60 70 80 90 100
YSRKFDGVTV EQLKLSEGDI DAACARVDEE IKLAVSQAIT NIDTFHQAQK
110 120 130 140 150
FEPVNIETQK GIRCELRSEP IEKVGLYIPG GSAPLISTVL MLALPAKIAG
160 170 180 190 200
CEQRVLVSPP PINDAIVYAA NACGITEILQ VGGAQAIAAL AFGTESVPAV
210 220 230 240 250
DKIFGPGNRY VTEAKRIVSQ DSRCVVSIDM PAGPSEVLLI ADSDANAEFI
260 270 280 290 300
AADLLSQAEH GPDSQVMLVT DCSALADEVN LALARQLELL PRVDIAEVAL
310 320 330 340 350
ESSRTLLVEN MEQAAQVSNL YGPEHLIIQT QNPREVLKQI RAAGSVFLGA
360 370 380 390 400
YTPESVGDYA SGTNHVLPTY GYSRAVSSLS LADFSRRFTV QELSAEGLIG
410 420 430
LSQTVMTLAA AEQLDAHKNA VAIRIASLQS DVAAQAKGV
Length:439
Mass (Da):46,674
Last modified:November 13, 2007 - v1
Checksum:i1FA189C96C78C7EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV37149.1.
RefSeqiWP_012142882.1. NC_009831.1.
YP_001474277.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV37149; ABV37149; Ssed_2542.
GeneIDi5612964.
KEGGisse:Ssed_2542.
PATRICi23562755. VBISheSed62411_2716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000821 Genomic DNA. Translation: ABV37149.1 .
RefSeqi WP_012142882.1. NC_009831.1.
YP_001474277.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8FWC6.
SMRi A8FWC6. Positions 2-431.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_2542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV37149 ; ABV37149 ; Ssed_2542 .
GeneIDi 5612964.
KEGGi sse:Ssed_2542.
PATRICi 23562755. VBISheSed62411_2716.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi SQDSRCV.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SSED425104:GH7Q-2640-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3Imported.

Entry informationi

Entry nameiA8FWC6_SHESH
AccessioniPrimary (citable) accession number: A8FWC6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3