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A8FUV3

- THIG_SHESH

UniProt

A8FUV3 - THIG_SHESH

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Protein

Thiazole synthase

Gene
thiG, Ssed_2017
Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S By similarity.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Schiff-base intermediate with DXP By similarity
Binding sitei156 – 1561DXP; via amide nitrogen By similarity

GO - Molecular functioni

  1. 2-iminoacetate synthase activity Source: InterPro
  2. sulfurtransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-2081-MONOMER.
UniPathwayiUPA00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiazole synthase (EC:2.8.1.10)
Gene namesi
Name:thiG
Ordered Locus Names:Ssed_2017
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Thiazole synthaseUniRule annotationPRO_1000080880Add
BLAST

Interactioni

Subunit structurei

Homotetramer. Forms heterodimers with either ThiH or ThiS By similarity.

Protein-protein interaction databases

STRINGi425104.Ssed_2017.

Structurei

3D structure databases

ProteinModelPortaliA8FUV3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 1832DXP binding By similarity
Regioni204 – 2052DXP binding By similarity

Sequence similaritiesi

Belongs to the ThiG family.

Phylogenomic databases

eggNOGiCOG2022.
HOGENOMiHOG000248049.
KOiK03149.
OMAiGSQLVTM.
OrthoDBiEOG6KMBD9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00443. ThiG.
InterProiIPR013785. Aldolase_TIM.
IPR008867. ThiG.
[Graphical view]
PfamiPF05690. ThiG. 1 hit.
[Graphical view]
SUPFAMiSSF110399. SSF110399. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FUV3-1 [UniParc]FASTAAdd to Basket

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MLKIAEHEFN SRLFTGTGKF SSANLMLEAI QASQSQLVTM AMKRLDLSSG    50
SDEILLPLQQ SGIKLLPNTS GARNAKEAVF AAELAREVLN TNWVKLEIHP 100
DPKYLMPDPI ETLAAAKTLC DKGFVVLPYV HADPVLCRRL EEVGCAAVMP 150
LASPIGSNQG LATETFLKII IEQASVPVVV DAGIGTPSQA THAMELGADA 200
VLVNTAIASS RDPIAMARCF SQAVETGRAA YRAGLGQVSV RAEHTSPLTG 250
FLNE 254
Length:254
Mass (Da):27,054
Last modified:November 13, 2007 - v1
Checksum:iD63C92FD77A6EFE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV36626.1.
RefSeqiWP_012142361.1. NC_009831.1.
YP_001473754.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV36626; ABV36626; Ssed_2017.
GeneIDi5613839.
KEGGisse:Ssed_2017.
PATRICi23561542. VBISheSed62411_2145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV36626.1 .
RefSeqi WP_012142361.1. NC_009831.1.
YP_001473754.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8FUV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_2017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV36626 ; ABV36626 ; Ssed_2017 .
GeneIDi 5613839.
KEGGi sse:Ssed_2017.
PATRICi 23561542. VBISheSed62411_2145.

Phylogenomic databases

eggNOGi COG2022.
HOGENOMi HOG000248049.
KOi K03149.
OMAi GSQLVTM.
OrthoDBi EOG6KMBD9.

Enzyme and pathway databases

UniPathwayi UPA00060 .
BioCyci SSED425104:GH7Q-2081-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00443. ThiG.
InterProi IPR013785. Aldolase_TIM.
IPR008867. ThiG.
[Graphical view ]
Pfami PF05690. ThiG. 1 hit.
[Graphical view ]
SUPFAMi SSF110399. SSF110399. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiTHIG_SHESH
AccessioniPrimary (citable) accession number: A8FUV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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