Reviewed, UniProtKB/Swiss-Prot A8FRE9 (ASTD_SHESH)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	Ssed_0811

Organism

Shewanella sediminis (strain HAW-EB3) [Complete proteome] [HAMAP]

Taxonomic identifier

425104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_1000085409
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	277	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8FRE9-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: E19CDD8696D85E48	FASTA	486	51,867
	10 20 30 40 50 60 MTQFIKGQWV AGLGHAVTSK NPANNDVIWN SQTATPEQVN TAVEAAREVQ FDWFMLGFEA 70 80 90 100 110 120 RLAIVEAYRA QLEENKAEIA ETIAQETGKP QWETATEAGA MIGKIGLSVA AYNKRTGTSE 130 140 150 160 170 180 NDTPAGRAVL RHKPHGVVAV FGPYNFPGHL PNGHIVPALL AGNTVVFKPS ELTPKVAELM 190 200 210 220 230 240 LKLWEKAGLP AGVINLVQGE VETGKALASH PQIDGLFFTG SSRTGHILHQ QYAGEPGKIL 250 260 270 280 290 300 ALEMGGNNPL IIKGVKDSKA AVHDIIQSAY ISSGQRCTCA RRLYVEKGAE GDALLAQLTD 310 320 330 340 350 360 AVKRIVVGAW NAQPQPFMGA MISETAAKGM VEAQRNLVNL GGHSLVELTH IEEGTGLVSP 370 380 390 400 410 420 GLIDVSQVIE LPDEEYFGPL LQVVRYTDFD EAIKLANNTR YGLSAGILAD SRDDYEYFLA 430 440 450 460 470 480 RIRAGIVNWN KQITGASGAA PFGGVGASGN HRASAFYAAD YCAYPVASVE ADEVSLPANL SPGLSL

References

[1]

"Complete sequence of Shewanella sediminis HAW-EB3." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Zhao J.-S., Richardson P. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000821 Genomic DNA. Translation: ABV35422.1.
RefSeq	YP_001472550.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5611705.
GenomeReviews	Gene locus Ssed_0811 in contig CP000821_GR.
KEGG	sse:Ssed_0811.
NMPDR	fig|425104.3.peg.717.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_SHESH

Accession

Primary (citable) accession number: A8FRE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 13, 2007
Last modified:	November 25, 2008
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)