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A8FQV1

- FTHS_SHESH

UniProt

A8FQV1 - FTHS_SHESH

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-634-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Ssed_0612
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000087658Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi425104.Ssed_0612.

Structurei

3D structure databases

ProteinModelPortaliA8FQV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiAMTVIMS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8FQV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTDIEISRQ TKHRPITQIA EKFGITSSEL VPFGDAKAKV KLSILKRVDD
60 70 80 90 100
NLEGKLVIVT AVTPTPFGEG KTVTSIGLTQ GLNALGKKAC ACIRQPSMGP
110 120 130 140 150
VFGIKGGAAG GGYSQVVPME ELNLHLTGDI HAVSSAHNLA AAAIDARLFH
160 170 180 190 200
ESRMTADEYR EQSGQAPLNI DPEKILWRRV VDHNERSLRN ITVGLGANNG
210 220 230 240 250
PIHDSGFDIT AASELMAILA LSLDLKDMRR RIGKLVLALD SLGQPITAET
260 270 280 290 300
LGVAGAMTVI MSDAIEPTLM QTLTGDPCLI HAGPFANIAH GNSSIIADRI
310 320 330 340 350
ALKLADIVVT EGGFGSDMGF EKFCNIKTRV SGKTPDAAVV VVTLKALKAN
360 370 380 390 400
SGIDSQNDIN RPDMARLQVG FANLKWHIDN VSQYGAPVVV AINRFPTDTF
410 420 430 440 450
EELTWLKAKV LETAAFGCEI CEGFSQGAKG AEALARVVVS ATEQKSDFKF
460 470 480 490 500
LYQLDESIES KLLTIAEAGY GAAGIKLSPD AKIQLQEINS MGLDKLAVCV
510 520 530 540 550
AKTPLSISHE PKVKGVPTDF ELPITQLKIN AGAGFITALV GKVMTMPGLG
560 570
IKPGYLNVDI NEDDEIVGLA
Length:570
Mass (Da):60,653
Last modified:November 13, 2007 - v1
Checksum:i9D17A7AD4F060564
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV35224.1.
RefSeqiYP_001472352.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV35224; ABV35224; Ssed_0612.
GeneIDi5613126.
KEGGisse:Ssed_0612.
PATRICi23558462. VBISheSed62411_0646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV35224.1 .
RefSeqi YP_001472352.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8FQV1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_0612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV35224 ; ABV35224 ; Ssed_0612 .
GeneIDi 5613126.
KEGGi sse:Ssed_0612.
PATRICi 23558462. VBISheSed62411_0646.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi AMTVIMS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSED425104:GH7Q-634-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiFTHS_SHESH
AccessioniPrimary (citable) accession number: A8FQV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3