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A8FQV1

- FTHS_SHESH

UniProt

A8FQV1 - FTHS_SHESH

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSED425104:GH7Q-634-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Ssed_0612
    OrganismiShewanella sediminis (strain HAW-EB3)
    Taxonomic identifieri425104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002015: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000087658Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi425104.Ssed_0612.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FQV1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiAMTVIMS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8FQV1-1 [UniParc]FASTAAdd to Basket

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    MLTDIEISRQ TKHRPITQIA EKFGITSSEL VPFGDAKAKV KLSILKRVDD    50
    NLEGKLVIVT AVTPTPFGEG KTVTSIGLTQ GLNALGKKAC ACIRQPSMGP 100
    VFGIKGGAAG GGYSQVVPME ELNLHLTGDI HAVSSAHNLA AAAIDARLFH 150
    ESRMTADEYR EQSGQAPLNI DPEKILWRRV VDHNERSLRN ITVGLGANNG 200
    PIHDSGFDIT AASELMAILA LSLDLKDMRR RIGKLVLALD SLGQPITAET 250
    LGVAGAMTVI MSDAIEPTLM QTLTGDPCLI HAGPFANIAH GNSSIIADRI 300
    ALKLADIVVT EGGFGSDMGF EKFCNIKTRV SGKTPDAAVV VVTLKALKAN 350
    SGIDSQNDIN RPDMARLQVG FANLKWHIDN VSQYGAPVVV AINRFPTDTF 400
    EELTWLKAKV LETAAFGCEI CEGFSQGAKG AEALARVVVS ATEQKSDFKF 450
    LYQLDESIES KLLTIAEAGY GAAGIKLSPD AKIQLQEINS MGLDKLAVCV 500
    AKTPLSISHE PKVKGVPTDF ELPITQLKIN AGAGFITALV GKVMTMPGLG 550
    IKPGYLNVDI NEDDEIVGLA 570
    Length:570
    Mass (Da):60,653
    Last modified:November 13, 2007 - v1
    Checksum:i9D17A7AD4F060564
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV35224.1.
    RefSeqiWP_012140961.1. NC_009831.1.
    YP_001472352.1. NC_009831.1.

    Genome annotation databases

    EnsemblBacteriaiABV35224; ABV35224; Ssed_0612.
    GeneIDi5613126.
    KEGGisse:Ssed_0612.
    PATRICi23558462. VBISheSed62411_0646.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000821 Genomic DNA. Translation: ABV35224.1 .
    RefSeqi WP_012140961.1. NC_009831.1.
    YP_001472352.1. NC_009831.1.

    3D structure databases

    ProteinModelPortali A8FQV1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 425104.Ssed_0612.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV35224 ; ABV35224 ; Ssed_0612 .
    GeneIDi 5613126.
    KEGGi sse:Ssed_0612.
    PATRICi 23558462. VBISheSed62411_0646.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi AMTVIMS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SSED425104:GH7Q-634-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB3.

    Entry informationi

    Entry nameiFTHS_SHESH
    AccessioniPrimary (citable) accession number: A8FQV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3