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A8FQD4

- PUR9_SHESH

UniProt

A8FQD4 - PUR9_SHESH

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Ssed_0444
Organism
Shewanella sediminis (strain HAW-EB3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSSED425104:GH7Q-466-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Ssed_0444
OrganismiShewanella sediminis (strain HAW-EB3)
Taxonomic identifieri425104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002015: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000076495Add
BLAST

Proteomic databases

PRIDEiA8FQD4.

Interactioni

Protein-protein interaction databases

STRINGi425104.Ssed_0444.

Structurei

3D structure databases

ProteinModelPortaliA8FQD4.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A8FQD4-1 [UniParc]FASTAAdd to Basket

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MNNARPIRRA LLSVSDKTGI LEFAKSLHAQ GVELLSTGGT ARLLADNGVP    50
VIEVSDHTGH PEIMDGRVKT LHPKVHGGIL ARRGIDELVM EQNNIKPIDL 100
VAVNLYPFAE TVAKEGCTLA DAVENIDIGG PTMVRSTAKN HKDTTIIVNA 150
SDYDRVIVEM NANEGSTTLE TRFDLAIAAF EHTAAYDGMI ANYFGTQVPA 200
HSKDECHHDS KFPRTYNTQL VKKQDLRYGE NSHQTAAFYV DSPSFNGQGD 250
EASVASAIQL QGKALSYNNI ADTDSALECV KEFSEPACVI VKHANPCGVA 300
IGSDLLDAYN RAFKTDPTSA FGGIIAFNGE LDAATASAIV ERQFVEVIIA 350
PKVSQAARDI VAAKANLRLL ECGEWNTKTT SLDYKRVNGG LLLQDRDQGM 400
VGLDDVKVVS KRQPTAAEMK DLMFCWKVAK FVKSNAIVYA KDSMTIGVGA 450
GQMSRVYSAK VAGIKAADEG LEVQDSVMAS DAFFPFRDGI DAAAAAGISC 500
IIQPGGSIRD EEIIAAADEH GMAMVFTGMR HFRH 534
Length:534
Mass (Da):57,499
Last modified:November 13, 2007 - v1
Checksum:iF31C3217A554A2F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV35057.1.
RefSeqiWP_012140794.1. NC_009831.1.
YP_001472185.1. NC_009831.1.

Genome annotation databases

EnsemblBacteriaiABV35057; ABV35057; Ssed_0444.
GeneIDi5612542.
KEGGisse:Ssed_0444.
PATRICi23558098. VBISheSed62411_0465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000821 Genomic DNA. Translation: ABV35057.1 .
RefSeqi WP_012140794.1. NC_009831.1.
YP_001472185.1. NC_009831.1.

3D structure databases

ProteinModelPortali A8FQD4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 425104.Ssed_0444.

Proteomic databases

PRIDEi A8FQD4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV35057 ; ABV35057 ; Ssed_0444 .
GeneIDi 5612542.
KEGGi sse:Ssed_0444.
PATRICi 23558098. VBISheSed62411_0465.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SSED425104:GH7Q-466-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB3.

Entry informationi

Entry nameiPUR9_SHESH
AccessioniPrimary (citable) accession number: A8FQD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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