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A8FMY4

- TRMB_CAMJ8

UniProt

A8FMY4 - TRMB_CAMJ8

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, C8J_1222
Organism
Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231S-adenosyl-L-methionine By similarity
Binding sitei148 – 1481S-adenosyl-L-methionine By similarity
Binding sitei175 – 1751S-adenosyl-L-methionine By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei231 – 2311Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCJEJ407148:GHCS-1258-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:C8J_1222
    OrganismiCampylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
    Taxonomic identifieri407148 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000002013: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_1000072996Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi407148.C8J_1222.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FMY4.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000252163.
    KOiK03439.
    OMAiSKYEARW.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8FMY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNFKSKKIK EINLPYSKDD VEFLWLAKND NVSLIYTKVQ EESFFLQIKK    50
    AQNGFVIKGD KHTKPSKIGY LQKALKIFKE GFCEDIINEA FGLKNNALIE 100
    KTPFIVDNFD ELLSKLQGKI YIEIGFGSGR HLLYQAKENP NVLILGVEIY 150
    NPALTQVAKL AKVQNVNNIL LIQSDARLLL SVLKSKSVEK IFLHFPVPWD 200
    KKPHRRVIGK DFCKECARVL TQNGRFELRT DSFEYFNFTL EQFLTFPAPK 250
    FSLRKNENLE ISSKYEDRWK KQEKNIYDLW VWNFNQECKN YELNEFNLSS 300
    VEFSKEDLKK IEQNFKNITI KKDDFFLHFE SIYKQDENLL LKVAFGAFNK 350
    PEHCYLHLDK TIDFVFKEPF KIQENIKAIN ELKEILKVQF KI 392
    Length:392
    Mass (Da):46,215
    Last modified:November 13, 2007 - v1
    Checksum:iCE2BE0CBE8DDD2DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000814 Genomic DNA. Translation: ABV52821.1.
    RefSeqiYP_001482798.1. NC_009839.1.

    Genome annotation databases

    EnsemblBacteriaiABV52821; ABV52821; C8J_1222.
    GeneIDi5617444.
    KEGGicju:C8J_1222.
    PATRICi20056078. VBICamJej119085_1232.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000814 Genomic DNA. Translation: ABV52821.1 .
    RefSeqi YP_001482798.1. NC_009839.1.

    3D structure databases

    ProteinModelPortali A8FMY4.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 407148.C8J_1222.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV52821 ; ABV52821 ; C8J_1222 .
    GeneIDi 5617444.
    KEGGi cju:C8J_1222.
    PATRICi 20056078. VBICamJej119085_1232.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000252163.
    KOi K03439.
    OMAi SKYEARW.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CJEJ407148:GHCS-1258-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Campylobacter jejuni strain 81116 (NCTC11828)."
      Pearson B.M., Gaskin D.J.H., Segers R.P.A.M., Wells J.M., Nuijten P.J.M., van Vliet A.H.M.
      J. Bacteriol. 189:8402-8403(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 81116 / NCTC 11828.

    Entry informationi

    Entry nameiTRMB_CAMJ8
    AccessioniPrimary (citable) accession number: A8FMY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 13, 2007
    Last modified: June 11, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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