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A8FME4

- SYL_CAMJ8

UniProt

A8FME4 - SYL_CAMJ8

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei582 – 5821ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCJEJ407148:GHCS-1067-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:C8J_1032
    OrganismiCampylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
    Taxonomic identifieri407148 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000002013: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 809809Leucine--tRNA ligasePRO_1000071109Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi407148.C8J_1032.

    Structurei

    3D structure databases

    ProteinModelPortaliA8FME4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi579 – 5835"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8FME4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYEASLIEK KWQKIWDENE YFEPKDDLNL PKKYILSMFP YPSGRIHMGH    50
    VRNYTIGDAL ARYYRKIGFN VLHPIGFDSF GMPAENAAIK HKIHPKSWTY 100
    ENIAYMKKEL FSLGFSFSKK RMLATSDPLY TKFEQEFFIK MFEKGLIYTK 150
    EANVNWCEQD QTVLANEQVE DGKCWRCGHE VVQKKMPGYY VKITAYAEEL 200
    LKDLEELKDK WPNQVLTMQE NWIGKSEGLE FSLNLDEESK QKTKESSLEV 250
    FTTRADTIYG VSYIALAPEH KIVQNLLSQN LLNQDVLNKI KAIQNQSPRE 300
    RQSSEKEGYF LGIYAIHPLS GEKIPLWVAN FVLADYGSGA VMAVPAHDER 350
    DFEFATKYNL AIKQVIQTQE NLPYTQKSGK LIHSQEFDNL DCNEARLKII 400
    SQFEAKNIGK RVVNFKIRDW GVSRQRYWGA PIPMIKCQSC GIVPQKLENL 450
    PITLPEDVQI TGEGNPLDKH PTWKNCICPK CGKEAQKESD TLDTFFESSW 500
    YFARFASDEK TWQEKALDEK SVKYWMSVDQ YIGGIEHAIL HLLYARFFQK 550
    ALRDLGYLTQ NEPFDRLLTQ GMVLKDGAKM SKSKGNVVDP DEIIEKYGAD 600
    TARLFILFAA PPAKELEWND DAVEGAYRFI CKLYDRAQNV KKGELVELKQ 650
    ENLNKEEKYA RLKVYEALKK SFEVYHQSFA FNTLIAACME ALNALALCKN 700
    EALEQEAFYI ILNILEPIIP HVCFELSEEL FKCKNFKKLE LKEEIFVKDT 750
    LNLAVSINGK KRAEFEISSS ASKEEILAFA KENTAKWLEG KSIVKEIYVE 800
    GKLVNLVIK 809
    Length:809
    Mass (Da):93,384
    Last modified:November 13, 2007 - v1
    Checksum:i4F211E934AD03141
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000814 Genomic DNA. Translation: ABV52631.1.
    RefSeqiYP_001482608.1. NC_009839.1.

    Genome annotation databases

    EnsemblBacteriaiABV52631; ABV52631; C8J_1032.
    GeneIDi5617729.
    KEGGicju:C8J_1032.
    PATRICi20055696. VBICamJej119085_1042.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000814 Genomic DNA. Translation: ABV52631.1 .
    RefSeqi YP_001482608.1. NC_009839.1.

    3D structure databases

    ProteinModelPortali A8FME4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 407148.C8J_1032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV52631 ; ABV52631 ; C8J_1032 .
    GeneIDi 5617729.
    KEGGi cju:C8J_1032.
    PATRICi 20055696. VBICamJej119085_1042.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CJEJ407148:GHCS-1067-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Campylobacter jejuni strain 81116 (NCTC11828)."
      Pearson B.M., Gaskin D.J.H., Segers R.P.A.M., Wells J.M., Nuijten P.J.M., van Vliet A.H.M.
      J. Bacteriol. 189:8402-8403(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 81116 / NCTC 11828.

    Entry informationi

    Entry nameiSYL_CAMJ8
    AccessioniPrimary (citable) accession number: A8FME4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3