A8FM44 (A8FM44_CAMJ8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Name:	hemB EMBL ABV52531.1
Ordered Locus Names:	C8J_0932

Organism

Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828) [Complete proteome] [HAMAP]

Taxonomic identifier

407148 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515 PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ABV52531.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	196	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	249	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	119	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	121	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	129	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	234	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	206	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	218	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	275	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	314	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A8FM44 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 7A6A534D617744FF	FASTA	327	36,381
	10 20 30 40 50 60 MFKRFRRLRL NENLRAMVRE NSLSVNDLIY PLFVVNGTGI KKEISSMPDV FQMGLDEILK 70 80 90 100 110 120 ECQNVVNLGI KAIILFGVLE NEKKDSCGSD ALDDKGLVAR SIREIKKNFP DLFIISDLCF 130 140 150 160 170 180 CEYTDHGHCG IIDPKTKSVD NDATLEISAK QALVHARAGV DMIAPSGMMD GIITTLRKAL 190 200 210 220 230 240 DKEGFENLPI MAYSTKFASS YYGPFRDVAE SAPSYGDRKS YQMDFANGKE ALEESLEDEA 250 260 270 280 290 300 QGADILMVKP ALAYLDVVKE ISLHSNLPLC VYNVSGEYAM LKAAKNAGVI DYEKVLYETM 310 320 IAFKRAGAKL IITYHAKELA KMLKGEK

References

[1]	"The complete genome sequence of Campylobacter jejuni strain 81116 (NCTC11828)." Pearson B.M., Gaskin D.J.H., Segers R.P.A.M., Wells J.M., Nuijten P.J.M., van Vliet A.H.M. J. Bacteriol. 189:8402-8403(2007) [PubMed: 17873037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000814 Genomic DNA. Translation: ABV52531.1.
RefSeq	YP_001482508.1. NC_009839.1.
3D structure databases
ProteinModelPortal	A8FM44.
SMR	A8FM44. Positions 1-323.
ModBase	Search...
Protein-protein interaction databases
STRING	A8FM44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5617374.
GenomeReviews	Gene locus C8J_0932 in contig CP000814_GR.
KEGG	cju:C8J_0932.
PATRIC	20055492. VBICamJej119085_0941.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0113.
HOGENOM	HBG285270.
OMA	TEAYNEN.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8FM44_CAMJ8

Accession

Primary (citable) accession number: A8FM44

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)