UniProtKB - A8FLV4 (ALR_CAMJ8)
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Protein
Alanine racemase
Gene
alr
Organism
Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
Status
Functioni
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation
Catalytic activityi
L-alanine = D-alanine.UniRule annotation
Cofactori
pyridoxal 5'-phosphateUniRule annotation
: D-alanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Alanine racemase (alr)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 33 | Proton acceptor; specific for D-alanineUniRule annotation | 1 | |
Binding sitei | 118 | SubstrateUniRule annotation | 1 | |
Active sitei | 237 | Proton acceptor; specific for L-alanineUniRule annotation | 1 | |
Binding sitei | 283 | Substrate; via amide nitrogenUniRule annotation | 1 |
GO - Molecular functioni
- alanine racemase activity Source: UniProtKB-EC
GO - Biological processi
- D-alanine biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
UniPathwayi | UPA00042; UER00497 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:alr Ordered Locus Names:C8J_0842 |
Organismi | Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828) |
Taxonomic identifieri | 407148 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000138586 | 1 – 328 | Alanine racemaseAdd BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 33 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Structurei
3D structure databases
ProteinModelPortali | A8FLV4 |
SMRi | A8FLV4 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the alanine racemase family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000031446 |
KOi | K01775 |
OMAi | YSDGYRR |
Family and domain databases
Gene3Di | 2.40.37.102 hits 3.20.20.101 hit |
HAMAPi | MF_01201 Ala_racemase, 1 hit |
InterProi | View protein in InterPro IPR000821 Ala_racemase IPR009006 Ala_racemase/Decarboxylase_C IPR011079 Ala_racemase_C IPR001608 Ala_racemase_N IPR020622 Ala_racemase_pyridoxalP-BS IPR029066 PLP-binding_barrel |
Pfami | View protein in Pfam PF00842 Ala_racemase_C, 1 hit PF01168 Ala_racemase_N, 1 hit |
PRINTSi | PR00992 ALARACEMASE |
SMARTi | View protein in SMART SM01005 Ala_racemase_C, 1 hit |
SUPFAMi | SSF50621 SSF50621, 1 hit SSF51419 SSF51419, 1 hit |
TIGRFAMsi | TIGR00492 alr, 1 hit |
PROSITEi | View protein in PROSITE PS00395 ALANINE_RACEMASE, 1 hit |
i Sequence
Sequence statusi: Complete.
A8FLV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLIKIDQKA YEYNLRHIAK KIGSFQRLIC VFKDNAYGHG AKLLAPLAKN
60 70 80 90 100
LGVSFVAVKS EEEAQEIEEF FENILILSHR PHGNENSRFI YALNDISQVK
110 120 130 140 150
KYKQDIKIHL KIDTGMHRNG ICVENLEHAI DLIRSSDLKL TGMFTHFASA
160 170 180 190 200
DEMDGSFFVQ KENFQKAKKI VKKYFSNLLF HSHNSAALFR GKIPEDEYCR
210 220 230 240 250
VGLVQFGYGD SNLKRVLSLY AHRLSQRILQ KGQSIGYGGI FTAAKDMEVA
260 270 280 290 300
TYDLGYADGL FRYNGKGELV LGNGKVMLGK MSMDSFSCEN SGEEICVFKD
310 320
ADIWADFFHT INYEILVKLN PNIQRVLV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000814 Genomic DNA Translation: ABV52441.1 |
RefSeqi | WP_002865911.1, NC_009839.1 |
Genome annotation databases
EnsemblBacteriai | ABV52441; ABV52441; C8J_0842 |
KEGGi | cju:C8J_0842 |
Similar proteinsi
Entry informationi
Entry namei | ALR_CAMJ8 | |
Accessioni | A8FLV4Primary (citable) accession number: A8FLV4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | November 13, 2007 | |
Last modified: | April 25, 2018 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |