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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:C8J_0596
OrganismiCampylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
Taxonomic identifieri407148 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000734991 – 165Peptide methionine sulfoxide reductase MsrAAdd BLAST165

Structurei

3D structure databases

ProteinModelPortaliA8FL58
SMRiA8FL58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263863
KOiK07304
OMAiGYCAFVV

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

A8FL58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNIVLGGGC FWCVEAVFER LKGVIDTEVG YSGGNPNPSY ESVCNGDGNI
60 70 80 90 100
EVVKINYDEK QISLLEILTL FFKIHDPTSI DKQGGDIGIQ YRSIIFYENE
110 120 130 140 150
EDKILAQNFI EEQQKIFSKK IVTKISRLQT YYKAENYHQH YFINNPNQGY
160
CQAVIAPKLQ KIQSG
Length:165
Mass (Da):18,824
Last modified:November 13, 2007 - v1
Checksum:i8B785541F1A7ED13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000814 Genomic DNA Translation: ABV52195.1
RefSeqiWP_002866497.1, NC_009839.1

Genome annotation databases

EnsemblBacteriaiABV52195; ABV52195; C8J_0596
KEGGicju:C8J_0596

Similar proteinsi

Entry informationi

Entry nameiMSRA_CAMJ8
AccessioniPrimary (citable) accession number: A8FL58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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